[全文]丁盛Nat Methods新文章－－提高iPS诱导效率200倍

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Nat Methods. 2009 Oct 18.【Epub ahead of print】
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- X: z7 G4 i  L' Y+ n; e4 S8 |A chemical platform for improved induction of human iPSCs.
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; |) z; r- z6 f6 C3 P6 L/ mLin T, Ambasudhan R, Yuan X, Li W, Hilcove S, Abujarour R, Lin X, Hahm HS, Hao E, Hayek A, Ding S.. y: c2 v! l. s4 T8 |
Department of Chemistry, The Scripps Research Institute, La Jolla, California, USA.! j5 D+ k# w/ M6 Y% U+ g
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The slow kinetics and low efficiency of reprogramming methods to generate human induced pluripotent stem cells (iPSCs) impose major limitations on their utility in biomedical applications. Here we describe a chemical approach that dramatically improves (200-fold) the efficiency of iPSC generation from human fibroblasts, within seven days of treatment. This will provide a basis for developing safer, more efficient, nonviral methods for reprogramming human somatic cells., j5 U! N- c- q2 E6 m! e& w
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PMID: 1983816# L/ Z3 a4 H+ ?: e

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