[全文]丁盛Nat Methods新文章－－提高iPS诱导效率200倍

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Nat Methods. 2009 Oct 18.【Epub ahead of print】6 a/ H$ ~' y$ W
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2 y6 {7 x0 C9 GA chemical platform for improved induction of human iPSCs.
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Lin T, Ambasudhan R, Yuan X, Li W, Hilcove S, Abujarour R, Lin X, Hahm HS, Hao E, Hayek A, Ding S.
6 ]" `6 l# s# r- h! y/ q/ pDepartment of Chemistry, The Scripps Research Institute, La Jolla, California, USA.
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4 v& X' |& i" \6 L8 BThe slow kinetics and low efficiency of reprogramming methods to generate human induced pluripotent stem cells (iPSCs) impose major limitations on their utility in biomedical applications. Here we describe a chemical approach that dramatically improves (200-fold) the efficiency of iPSC generation from human fibroblasts, within seven days of treatment. This will provide a basis for developing safer, more efficient, nonviral methods for reprogramming human somatic cells.
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1 V1 R- y2 o# MPMID: 1983816
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