[全文]丁盛Nat Methods新文章－－提高iPS诱导效率200倍

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Nat Methods. 2009 Oct 18.【Epub ahead of print】
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A chemical platform for improved induction of human iPSCs.
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7 ]) D: k) @2 YLin T, Ambasudhan R, Yuan X, Li W, Hilcove S, Abujarour R, Lin X, Hahm HS, Hao E, Hayek A, Ding S.$ T# o2 K' d- n4 m& S4 c
Department of Chemistry, The Scripps Research Institute, La Jolla, California, USA.: b7 E* s* V( |" V

' n) n/ w' h$ ~; P+ c, N8 {The slow kinetics and low efficiency of reprogramming methods to generate human induced pluripotent stem cells (iPSCs) impose major limitations on their utility in biomedical applications. Here we describe a chemical approach that dramatically improves (200-fold) the efficiency of iPSC generation from human fibroblasts, within seven days of treatment. This will provide a basis for developing safer, more efficient, nonviral methods for reprogramming human somatic cells.
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PMID: 1983816% e- a/ D" Z1 U

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