microRNA与干细胞

细胞海洋

microRNA，包括miRNA、SiRNA和PiRNA等等。它们是基因表达、修饰、转录和翻译的调节者。近年来的研究证明，microRNA在干细胞的自我复制、定向分化和组织再生中，都起着十分重要的作用。它是干细胞特性、维持、转化功能的一个关键的调节者，是当前干细胞调节研究的一个重点。最近，Gangara Ju. VK和Lin H在Nature Stem Cell作了一篇综述，系统的总结了microRNA对干细胞调节作用. Z1 d" H) t4 q3 H% E+ h
7 z6 F: R+ }  A( O: W

9 R1 I' k6 e; I9 R9 }1 ^/ S- C5 m7 O
  C: s# f; V7 V  f- s- m
/ t0 p, t' g( K, `+ K; x
但是，microRNA对干细胞的调节作用还远远不止于此。它还参与细胞周期、细胞重建(Reprograming)、多能干细胞生成、信号传递、特异分化、Riches、修复、再生、变异、代谢等所有过程

maxiaorongqp

有这部综述的全文吗

细胞海洋

MicroRNA-134 Modulates the Differentiation of Mouse Embryonic Stem Cells, Where It Causes Post-Transcriptional Attenuation of Nanog and LRH1
; f) d5 t9 X# Y8 a- K$ W( ~+ qMicroRNA Regulation of Cell Lineages in Mouse and Human Embryonic Stem Cells   A, A+ b, V9 ~
MicroRNA Regulation of Stem Cell Fate
2 O  Z$ ^. I3 {! w* n% T9 L8 u; B% P/ CMicroRNA-145 Regulates OCT4, SOX2, and KLF4 and Represses Pluripotency in Human Embryonic Stem Cells
4 z7 J  Z% Q3 S! }MicroRNA-145 to control human embryonic stem cell (hESC) pluripotency and differentiation ; ~$ }5 W" }+ d2 Z$ f/ ?
A feedback regulatory loop involving microRNA-9 and nuclear receptor TLX in neural stem cell fate determination / [* z; R& [: o: u
An embryonic stem cell chromatin remodeling complex, esBAF, is an essential component of the core pluripotency transcriptional network
8 [% S" P' f  A+ k+ M& qca-let-7 microRNAs in development, stem cells and cancer 8 i, w3 Q) I- Q+ D6 R! x. p
Ca-Metastasis-from dissemination to organ-specific colonization ' C! m0 V$ \! s, C# k3 p0 Q; d2 [# g
Cell Cycle Regulation by MicroRNAs in Embryonic Stem Cells
! W) h& T3 n. \7 L! U( p# Q8 V. bChromosome instability is common in human cleavage-stage embryos 1 h+ c. J3 n/ x$ p* _# i& v! a
Comprehensive MicroRNA Profiling Reveals a Unique Human Embryonic Stem Cell 0 j% E  S7 h. y
Connecting microRNA Genes to the Core Transcriptional Regulatory Circuitry of Embryonic Stem Cells
5 `) i: F' X! `Differentiating human multipotent mesenchymal stromal cells regulate microRNAs # o( E3 s; I( \* }. F, S# M6 _
Embryonic stem cell–specific microRNAs regulate the G1-S transition and promote rapid proliferation
7 A7 W8 n8 t: m# K! A( N, `4 fHMGA2, MicroRNAs, and Stem Cell Aging ' m8 k) e/ l5 P( ]$ E" H  O
Lin-28 interaction with the Let-7 precursor loop mediates regulated microRNA processing
! z' _2 q5 l7 t+ G& u1 F6 TLin28 Mediates the Terminal Uridylation of let-7 Precursor MicroRNA
; J/ F# X, D5 j* M! H' v/ ~Long noncoding RNAs in mouse embryonic stem cell pluripotency and differentiation * r# M& Q% Z# @* [+ R: f
MicroRNA-134 Modulates the Differentiation of Mouse Embryonic Stem Cells
- l( S: B" G! J# Q% ^0 BmiR-145 in Stem Cell Differentiation : m3 K2 z$ ^* a" f+ s" h
MIR-451 and Imatinib mesylate inhibit tumor growth of Glioblastoma stem cells   x, _$ q) [. J: Q
miR-9 and TLX-chasing tails in neural stem cells 2 S- T0 Y; L" q7 H( _% g: J
Multipotent adult germline stem cells and embryonic stem cells have similar microRNA profiles
8 [* {3 o# ]5 k/ u1 b6 i. m; c+ v: F# EPluripotent stem cell lines ; t% h- _" y% x# o1 r# s: O
Regulatory circuits underlying pluripotency and reprogramming
& G% B) J3 Q) J5 c9 Vsc-MicroRNAs to , and coding regions modulate embryonic stem cell differentiation
4 x/ s( c* y* k& q2 V9 Msc-MicroRNAs-key regulators of stem cells * i5 O3 x$ ~5 G* m) _
MicroRNA Regulation of Cell Lineages in Mouse and Human Embryonic Stem Cells 8 K) P( T* f) b
Stem cells-MicroRNAs promote differentiation
, J! o5 Y5 R" |" }- F8 x3 |sc-MicroRNA Expression in Multipotent Mesenchymal Stromal Cells + e7 `4 l9 m1 ?2 q7 l$ ~
Stem cells- MicroRNAs promote differentiation + {1 {6 k5 T% M  I; A* B. D0 {% v  S
MicroRNA regulation directs lineage-and developmental stage-specific transgene expression in hematopoietic stem cell progeny

guanjiyu

谢谢分享

fuguangbo

好文章！谢谢！

sacia

好东西~楼主辛苦了！！

ouyi2738

Embryonic stem cell–specific microRNAs promote induced pluripotency

sdyinong

谢谢

yaner

有全文吗

Rainnie

microRNA，包括miRNA、SiRNA和PiRNA等等。它们是基因表达、修饰、转录和翻译的调节者。近年来的研究证明，m ...
* F7 X" Q/ ^! l, }" H细胞海洋 发表于 2009-10-29 18:58

$ G4 O1 p# G. V3 ~9 m% k
. f" O$ `" d% r: p, Y# K, w& u  a. M) m, b7 Q4 \
   全文有么？