microRNA与干细胞

细胞海洋

microRNA，包括miRNA、SiRNA和PiRNA等等。它们是基因表达、修饰、转录和翻译的调节者。近年来的研究证明，microRNA在干细胞的自我复制、定向分化和组织再生中，都起着十分重要的作用。它是干细胞特性、维持、转化功能的一个关键的调节者，是当前干细胞调节研究的一个重点。最近，Gangara Ju. VK和Lin H在Nature Stem Cell作了一篇综述，系统的总结了microRNA对干细胞调节作用. E" i. p) ^+ q8 B

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0 P% X5 t: s7 w但是，microRNA对干细胞的调节作用还远远不止于此。它还参与细胞周期、细胞重建(Reprograming)、多能干细胞生成、信号传递、特异分化、Riches、修复、再生、变异、代谢等所有过程

maxiaorongqp

有这部综述的全文吗

细胞海洋

MicroRNA-134 Modulates the Differentiation of Mouse Embryonic Stem Cells, Where It Causes Post-Transcriptional Attenuation of Nanog and LRH1 6 d- q7 \; L* I
MicroRNA Regulation of Cell Lineages in Mouse and Human Embryonic Stem Cells
: }. S9 q0 H' HMicroRNA Regulation of Stem Cell Fate 7 D# j: z! J1 a, L
MicroRNA-145 Regulates OCT4, SOX2, and KLF4 and Represses Pluripotency in Human Embryonic Stem Cells 1 f) p3 z( j2 a0 O% K* B+ x( w
MicroRNA-145 to control human embryonic stem cell (hESC) pluripotency and differentiation
/ C9 K$ j- _% e, o, RA feedback regulatory loop involving microRNA-9 and nuclear receptor TLX in neural stem cell fate determination
, v+ f( O; g: r# \5 Y* M4 UAn embryonic stem cell chromatin remodeling complex, esBAF, is an essential component of the core pluripotency transcriptional network
) w$ h1 I' k) ]- Q. a, ]ca-let-7 microRNAs in development, stem cells and cancer
- |) K. T( Y% Q9 l- Z6 u/ h0 UCa-Metastasis-from dissemination to organ-specific colonization & S, s6 H- C- P0 |/ Q- `% G
Cell Cycle Regulation by MicroRNAs in Embryonic Stem Cells & }: f% y- E! z! [
Chromosome instability is common in human cleavage-stage embryos ! T: f: d2 G( `
Comprehensive MicroRNA Profiling Reveals a Unique Human Embryonic Stem Cell
1 m' l1 c# v# I8 {% Z. _Connecting microRNA Genes to the Core Transcriptional Regulatory Circuitry of Embryonic Stem Cells ! A; ^/ h, Z- h1 S& k
Differentiating human multipotent mesenchymal stromal cells regulate microRNAs
" ]3 d% [+ Q; H; {1 LEmbryonic stem cell–specific microRNAs regulate the G1-S transition and promote rapid proliferation 8 J! l" ]0 E( \# J; k: g, P
HMGA2, MicroRNAs, and Stem Cell Aging 7 z, {* l9 O5 n) d
Lin-28 interaction with the Let-7 precursor loop mediates regulated microRNA processing / |+ H! M5 J) j: v5 }. g" v' C
Lin28 Mediates the Terminal Uridylation of let-7 Precursor MicroRNA 1 ~3 q: o$ U' k2 _) I: y
Long noncoding RNAs in mouse embryonic stem cell pluripotency and differentiation
/ z2 Q. f" s1 n6 I/ o4 f% X8 \MicroRNA-134 Modulates the Differentiation of Mouse Embryonic Stem Cells ; r- [: I, f( {0 H: E6 R
miR-145 in Stem Cell Differentiation ) o3 ^  q  V) u+ X
MIR-451 and Imatinib mesylate inhibit tumor growth of Glioblastoma stem cells
9 |' _" a7 G$ Z+ T! WmiR-9 and TLX-chasing tails in neural stem cells
! }& g8 `6 ~. Y+ {; T/ YMultipotent adult germline stem cells and embryonic stem cells have similar microRNA profiles
! ?3 N3 e+ t/ T2 N' H/ VPluripotent stem cell lines   s9 d9 `" q+ F
Regulatory circuits underlying pluripotency and reprogramming
( c9 n. O( |5 q0 [5 Jsc-MicroRNAs to , and coding regions modulate embryonic stem cell differentiation & e9 A6 c: d9 A, i
sc-MicroRNAs-key regulators of stem cells
( ~7 h' |$ j  v  Q. ~MicroRNA Regulation of Cell Lineages in Mouse and Human Embryonic Stem Cells
) T! t0 I5 w! t( I8 H: q9 _Stem cells-MicroRNAs promote differentiation
. v' V% h+ t& n- _% w$ bsc-MicroRNA Expression in Multipotent Mesenchymal Stromal Cells 5 M" K5 n1 C2 L7 i' S
Stem cells- MicroRNAs promote differentiation
: @, h1 S+ \0 L- ~9 t) V% IMicroRNA regulation directs lineage-and developmental stage-specific transgene expression in hematopoietic stem cell progeny

guanjiyu

谢谢分享

fuguangbo

好文章！谢谢！

sacia

好东西~楼主辛苦了！！

ouyi2738

Embryonic stem cell–specific microRNAs promote induced pluripotency

sdyinong

谢谢

yaner

有全文吗

Rainnie

microRNA，包括miRNA、SiRNA和PiRNA等等。它们是基因表达、修饰、转录和翻译的调节者。近年来的研究证明，m ...# s9 |' ^* U, \6 [; J
细胞海洋 发表于 2009-10-29 18:58

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6 p2 l% v3 b  Q1 F% D" W   全文有么？