microRNA与干细胞

细胞海洋

microRNA，包括miRNA、SiRNA和PiRNA等等。它们是基因表达、修饰、转录和翻译的调节者。近年来的研究证明，microRNA在干细胞的自我复制、定向分化和组织再生中，都起着十分重要的作用。它是干细胞特性、维持、转化功能的一个关键的调节者，是当前干细胞调节研究的一个重点。最近，Gangara Ju. VK和Lin H在Nature Stem Cell作了一篇综述，系统的总结了microRNA对干细胞调节作用
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' b1 N; q7 Y  [" Y但是，microRNA对干细胞的调节作用还远远不止于此。它还参与细胞周期、细胞重建(Reprograming)、多能干细胞生成、信号传递、特异分化、Riches、修复、再生、变异、代谢等所有过程

maxiaorongqp

有这部综述的全文吗

细胞海洋

MicroRNA-134 Modulates the Differentiation of Mouse Embryonic Stem Cells, Where It Causes Post-Transcriptional Attenuation of Nanog and LRH1   D& F% \$ \) h; B2 }# Y# A- U
MicroRNA Regulation of Cell Lineages in Mouse and Human Embryonic Stem Cells   A0 J. J% O: b* }9 D3 F4 e3 c
MicroRNA Regulation of Stem Cell Fate 8 T) s# h& j! E/ @
MicroRNA-145 Regulates OCT4, SOX2, and KLF4 and Represses Pluripotency in Human Embryonic Stem Cells % v% r- x: W5 ?( p
MicroRNA-145 to control human embryonic stem cell (hESC) pluripotency and differentiation
9 }0 d) C/ @8 r% oA feedback regulatory loop involving microRNA-9 and nuclear receptor TLX in neural stem cell fate determination
/ H$ ?, I% f9 _1 x$ ~( H) h6 ]An embryonic stem cell chromatin remodeling complex, esBAF, is an essential component of the core pluripotency transcriptional network
" a0 v2 u8 Z* T6 W# ?  ~ca-let-7 microRNAs in development, stem cells and cancer
4 D9 e1 v2 @; MCa-Metastasis-from dissemination to organ-specific colonization
6 x( Z  J5 F" p3 x9 j+ _# [0 k8 gCell Cycle Regulation by MicroRNAs in Embryonic Stem Cells
1 H; H" R* c" [6 [Chromosome instability is common in human cleavage-stage embryos
6 y! p  }' d. N" E8 n% UComprehensive MicroRNA Profiling Reveals a Unique Human Embryonic Stem Cell % J3 Y! @: `# U+ }7 y2 g$ M' y
Connecting microRNA Genes to the Core Transcriptional Regulatory Circuitry of Embryonic Stem Cells
9 G: B& I) V. p: G7 dDifferentiating human multipotent mesenchymal stromal cells regulate microRNAs
& K0 q8 e4 p( u; R: X, AEmbryonic stem cell–specific microRNAs regulate the G1-S transition and promote rapid proliferation
! w* Q4 ]" T9 jHMGA2, MicroRNAs, and Stem Cell Aging
& }) J( v  ^" x& ^4 d6 BLin-28 interaction with the Let-7 precursor loop mediates regulated microRNA processing
* V0 _% w! y6 ]# Q, ], NLin28 Mediates the Terminal Uridylation of let-7 Precursor MicroRNA
6 z+ a- L* N. ULong noncoding RNAs in mouse embryonic stem cell pluripotency and differentiation
0 m6 Q/ i  a  E  C" Y7 T' ^MicroRNA-134 Modulates the Differentiation of Mouse Embryonic Stem Cells
# p* K/ V5 v/ h: W: FmiR-145 in Stem Cell Differentiation ' ]4 G7 J' K7 h( h! D  w
MIR-451 and Imatinib mesylate inhibit tumor growth of Glioblastoma stem cells   E6 U8 L9 T% R6 x
miR-9 and TLX-chasing tails in neural stem cells & ~: Z  W9 F% F) e' r
Multipotent adult germline stem cells and embryonic stem cells have similar microRNA profiles
, k3 J% D( c. EPluripotent stem cell lines
$ N' b- z$ O. C2 H# _' Z: WRegulatory circuits underlying pluripotency and reprogramming
! z8 n) d1 p3 w8 v, s+ Z% osc-MicroRNAs to , and coding regions modulate embryonic stem cell differentiation # k% O3 s. O" e2 B+ B7 V
sc-MicroRNAs-key regulators of stem cells 1 x; f" z$ [# Z7 l* \9 G( Y
MicroRNA Regulation of Cell Lineages in Mouse and Human Embryonic Stem Cells
- E) y, f- g) Y, k$ mStem cells-MicroRNAs promote differentiation ) j6 R/ S: E" v. i. m6 C
sc-MicroRNA Expression in Multipotent Mesenchymal Stromal Cells
) Z0 o. J  ]; {. M7 Q+ lStem cells- MicroRNAs promote differentiation 5 W6 N  i4 f  Z# X1 ?- v
MicroRNA regulation directs lineage-and developmental stage-specific transgene expression in hematopoietic stem cell progeny

guanjiyu

谢谢分享

fuguangbo

好文章！谢谢！

sacia

好东西~楼主辛苦了！！

ouyi2738

Embryonic stem cell–specific microRNAs promote induced pluripotency

sdyinong

谢谢

yaner

有全文吗

Rainnie

microRNA，包括miRNA、SiRNA和PiRNA等等。它们是基因表达、修饰、转录和翻译的调节者。近年来的研究证明，m ...
1 T& L; f8 z6 ~: g1 _细胞海洋 发表于 2009-10-29 18:58

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   全文有么？