microRNA与干细胞

细胞海洋

microRNA，包括miRNA、SiRNA和PiRNA等等。它们是基因表达、修饰、转录和翻译的调节者。近年来的研究证明，microRNA在干细胞的自我复制、定向分化和组织再生中，都起着十分重要的作用。它是干细胞特性、维持、转化功能的一个关键的调节者，是当前干细胞调节研究的一个重点。最近，Gangara Ju. VK和Lin H在Nature Stem Cell作了一篇综述，系统的总结了microRNA对干细胞调节作用
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但是，microRNA对干细胞的调节作用还远远不止于此。它还参与细胞周期、细胞重建(Reprograming)、多能干细胞生成、信号传递、特异分化、Riches、修复、再生、变异、代谢等所有过程

maxiaorongqp

有这部综述的全文吗

细胞海洋

MicroRNA-134 Modulates the Differentiation of Mouse Embryonic Stem Cells, Where It Causes Post-Transcriptional Attenuation of Nanog and LRH1
  }7 h) \  b/ T8 H7 R/ UMicroRNA Regulation of Cell Lineages in Mouse and Human Embryonic Stem Cells : w+ E. ~* h5 ]  ~9 v
MicroRNA Regulation of Stem Cell Fate 5 i& K0 [, ?6 q6 u3 h0 I0 L9 X
MicroRNA-145 Regulates OCT4, SOX2, and KLF4 and Represses Pluripotency in Human Embryonic Stem Cells
0 h" W" f! c6 u4 P3 bMicroRNA-145 to control human embryonic stem cell (hESC) pluripotency and differentiation 1 ~6 R* l+ f) L' g
A feedback regulatory loop involving microRNA-9 and nuclear receptor TLX in neural stem cell fate determination
7 W% q; j! o' `& d9 V! EAn embryonic stem cell chromatin remodeling complex, esBAF, is an essential component of the core pluripotency transcriptional network
! k8 V9 o* c" R# `0 d$ y7 Nca-let-7 microRNAs in development, stem cells and cancer % Z+ A5 j8 M/ D( D
Ca-Metastasis-from dissemination to organ-specific colonization ) J$ K$ T9 W$ ^" Q+ Q. }% N  K
Cell Cycle Regulation by MicroRNAs in Embryonic Stem Cells
7 f9 U5 p6 r. D& K4 \1 GChromosome instability is common in human cleavage-stage embryos
- `% |, H1 p/ N& C$ jComprehensive MicroRNA Profiling Reveals a Unique Human Embryonic Stem Cell 8 E0 X% S/ A# o  }
Connecting microRNA Genes to the Core Transcriptional Regulatory Circuitry of Embryonic Stem Cells * \& K: M' a' k; e. j
Differentiating human multipotent mesenchymal stromal cells regulate microRNAs / C' O! ~- I2 u4 s3 V4 B
Embryonic stem cell–specific microRNAs regulate the G1-S transition and promote rapid proliferation 3 \" `/ e2 U, g1 ]* T$ x2 j; s
HMGA2, MicroRNAs, and Stem Cell Aging
# e/ _( u/ l+ l* m/ ~1 A6 gLin-28 interaction with the Let-7 precursor loop mediates regulated microRNA processing ! a/ \+ W' k' d( B6 _
Lin28 Mediates the Terminal Uridylation of let-7 Precursor MicroRNA
0 L1 X6 l! {# u# k! `Long noncoding RNAs in mouse embryonic stem cell pluripotency and differentiation
4 Z/ z/ W% _' Y3 N* tMicroRNA-134 Modulates the Differentiation of Mouse Embryonic Stem Cells 3 ]8 K/ L  Q" R% k, A- H
miR-145 in Stem Cell Differentiation
0 N, K) m% X+ QMIR-451 and Imatinib mesylate inhibit tumor growth of Glioblastoma stem cells   a9 ]/ \0 r1 b5 Z( Z- L
miR-9 and TLX-chasing tails in neural stem cells
8 T& h4 T; C4 z0 V. S1 |; MMultipotent adult germline stem cells and embryonic stem cells have similar microRNA profiles
' \6 `% y- e" ]Pluripotent stem cell lines & S- F9 X4 {0 B5 [/ S
Regulatory circuits underlying pluripotency and reprogramming
, C0 U  L2 y* }' k) e0 ssc-MicroRNAs to , and coding regions modulate embryonic stem cell differentiation
6 X! y! Z- L8 J- B  Qsc-MicroRNAs-key regulators of stem cells
2 ^! [- M7 O% G+ T/ F% yMicroRNA Regulation of Cell Lineages in Mouse and Human Embryonic Stem Cells 7 f7 L: J+ ^+ i" @% X/ T# Y( Y
Stem cells-MicroRNAs promote differentiation
2 |/ Z7 K  z5 o& L- xsc-MicroRNA Expression in Multipotent Mesenchymal Stromal Cells 3 v0 t; k3 k6 B6 q- y
Stem cells- MicroRNAs promote differentiation & \- S- G6 N0 _" W/ V
MicroRNA regulation directs lineage-and developmental stage-specific transgene expression in hematopoietic stem cell progeny

guanjiyu

谢谢分享

fuguangbo

好文章！谢谢！

sacia

好东西~楼主辛苦了！！

ouyi2738

Embryonic stem cell–specific microRNAs promote induced pluripotency

sdyinong

谢谢

yaner

有全文吗

Rainnie

microRNA，包括miRNA、SiRNA和PiRNA等等。它们是基因表达、修饰、转录和翻译的调节者。近年来的研究证明，m ...
1 }+ B0 a7 `0 B6 m细胞海洋 发表于 2009-10-29 18:58

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   全文有么？