SCIENCE心脏祖细胞文章

jianlindunev

REVIEW* d1 D! C) O* M
Cardiogenesis and the Complex2 v1 m6 C/ f4 M% N! O. k
Biology of Regenerative
4 z( r- u7 Y- B$ T- HCardiovascular Medicine
# }* {$ G9 @3 \, @Kenneth R. Chien,1,2* Ibrahim J. Domian,1 Kevin Kit Parker3
8 C& A, P2 T5 [, AThe heart is a complex organ system composed of a highly diverse set of muscle and nonmuscle
9 `0 p+ F2 y1 y& @cells. Understanding the pathways that drive the formation, migration, and assembly of these cells
6 `3 N; T& B  }* pinto the heart muscle tissue, the pacemaker and conduction system, and the coronary vasculature is
3 L+ j( i: F& V' D* Aa central problem in developmental biology. Efforts to unravel the biological complexity of in vivo1 [) X9 l  Q# i- s9 w
cardiogenesis have identified a family of closely related multipotent cardiac progenitor cells. These: s/ Y: \: {9 j  o. E6 P
progenitors must respond to non–cell-autonomous signaling cues to expand, differentiate, and
6 ~0 x, G8 r6 ~7 H% i! wultimately integrate into the three-dimensional heart structures. Coupling tissue-engineering
) G% R: b/ e  I0 dtechnologies with patient-specific cardiac progenitor biology holds great promise for the* M9 g: e8 W' c
development of human cell models of human disease and may lay the foundation for: H- V' K5 H3 |/ O% Y& \
novel approaches in regenerative cardiovascular medicine.

jiessiezhu

支持！好东西！

jianlindunev

全文