SCIENCE心脏祖细胞文章

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( z  ~# o7 H. }% oCardiogenesis and the Complex! U5 N5 {( Y4 B0 A
Biology of Regenerative# k: r7 H* J: v! o* W) F
Cardiovascular Medicine* ^, c  ~; \2 k6 P& b6 k: }* |
Kenneth R. Chien,1,2* Ibrahim J. Domian,1 Kevin Kit Parker3  A0 }& A* N8 x$ u
The heart is a complex organ system composed of a highly diverse set of muscle and nonmuscle
5 H% X; w) y3 r3 Hcells. Understanding the pathways that drive the formation, migration, and assembly of these cells
( Y& o* K/ z# h' f. n' u# o% ginto the heart muscle tissue, the pacemaker and conduction system, and the coronary vasculature is
: b, x+ E- J& F7 \' M2 h6 w9 s* ^a central problem in developmental biology. Efforts to unravel the biological complexity of in vivo
5 U4 C# `+ ?# |3 c3 ]cardiogenesis have identified a family of closely related multipotent cardiac progenitor cells. These; V! w6 F, @0 K  O* V5 Q, _
progenitors must respond to non–cell-autonomous signaling cues to expand, differentiate, and) ]6 e3 P& g; l- O! X* e9 x' P
ultimately integrate into the three-dimensional heart structures. Coupling tissue-engineering
) i# p3 t, G# Y1 E8 n# L, @technologies with patient-specific cardiac progenitor biology holds great promise for the
& n5 A; R% s; edevelopment of human cell models of human disease and may lay the foundation for+ \8 |" M- E" o* s, O
novel approaches in regenerative cardiovascular medicine.

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