SCIENCE心脏祖细胞文章

jianlindunev

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Cardiogenesis and the Complex: T: q$ J* n% k" G
Biology of Regenerative" I4 G: r" G  _% ]- b3 W& d6 G
Cardiovascular Medicine! H) @* ~9 K8 M* R: z+ v
Kenneth R. Chien,1,2* Ibrahim J. Domian,1 Kevin Kit Parker3
% i7 i. _1 k7 g& x0 zThe heart is a complex organ system composed of a highly diverse set of muscle and nonmuscle
7 Y/ o/ p+ d# ?% O- |cells. Understanding the pathways that drive the formation, migration, and assembly of these cells6 O. k( V( f/ }1 k# a: A7 m9 \9 T
into the heart muscle tissue, the pacemaker and conduction system, and the coronary vasculature is
# y2 w, z, p( l: l, Ea central problem in developmental biology. Efforts to unravel the biological complexity of in vivo
6 h/ i( ~; ]# Mcardiogenesis have identified a family of closely related multipotent cardiac progenitor cells. These: d' V7 p7 b# ]
progenitors must respond to non–cell-autonomous signaling cues to expand, differentiate, and
. m% y( [3 x$ j3 s. Y& sultimately integrate into the three-dimensional heart structures. Coupling tissue-engineering
! c- S- n4 g* o& R" ]3 i$ c, jtechnologies with patient-specific cardiac progenitor biology holds great promise for the
7 Z; A( C( Q9 |( e' c/ K4 ddevelopment of human cell models of human disease and may lay the foundation for$ s! j/ L$ X0 x
novel approaches in regenerative cardiovascular medicine.

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