SCIENCE心脏祖细胞文章

jianlindunev

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+ D. T9 s' @0 CCardiogenesis and the Complex
+ ]9 d. a7 c5 f# `$ YBiology of Regenerative+ \: \2 E) O! V* E9 }+ b
Cardiovascular Medicine
# h& z5 W9 |* m5 m1 D. [Kenneth R. Chien,1,2* Ibrahim J. Domian,1 Kevin Kit Parker3
  a8 q% v- B' q  |! `, x) q) KThe heart is a complex organ system composed of a highly diverse set of muscle and nonmuscle
9 ^4 M4 M! i; [0 B" Ncells. Understanding the pathways that drive the formation, migration, and assembly of these cells
# ^, Y6 P/ h! t2 X) N4 Finto the heart muscle tissue, the pacemaker and conduction system, and the coronary vasculature is/ c  u6 I$ S- [$ l4 V
a central problem in developmental biology. Efforts to unravel the biological complexity of in vivo
, x9 U" T- d' c" p7 P; vcardiogenesis have identified a family of closely related multipotent cardiac progenitor cells. These
2 \$ C9 z% C$ i# T  Pprogenitors must respond to non–cell-autonomous signaling cues to expand, differentiate, and
  d3 Y0 o% Q9 @% A& j& K6 xultimately integrate into the three-dimensional heart structures. Coupling tissue-engineering; E, w5 i# k  y+ I* ]
technologies with patient-specific cardiac progenitor biology holds great promise for the
' D6 X0 M8 |4 I, P1 F4 `  ^development of human cell models of human disease and may lay the foundation for* j( A( n4 e$ M* j) u
novel approaches in regenerative cardiovascular medicine.

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