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本帖最后由 qgjin 于 2010-5-10 00:42 编辑
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1 ?" j$ j! @/ s& e* d# wDerivation of Oocytes from Mouse Embryonic Stem Cells
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3 S& S! _3 n C' dKarin Hu¨bner,1 Guy Fuhrmann,3 Lane K. Christenson,4 James Kehler,1 Rolland Reinbold,1 Rabindranath De La Fuente,2 Jennifer Wood,4 Jerome F. Strauss III,4 Michele Boiani,1 Hans R. Scho¨ler1*% [. X* y4 |- r3 ?' g$ O8 ?
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Continuation of mammalian species requires the formation and development of the sexually dimorphic germ cells. Cultured embryonic stem cells are generally
2 U) ?3 u& L" `2 u: gconsidered pluripotent rather than totipotent because of the failure to detect germline cells under differentiating conditions. Here we show that
" e) b+ i3 N+ J' ~$ b' q6 a& amouse embryonic stem cells in culture can develop into oogonia that enter meiosis, recruit adjacent cells to form follicle-like structures, and later develop
$ W Y4 _1 u, T) w) p9 xinto blastocysts. Oogenesis in culture should contribute to various areas, including nuclear transfer and manipulation of the germ line, and advance studies
- H& K) B: K. e+ D- [8 `on fertility treatment and germ and somatic cell interaction and differentiation. |
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发表于 2010-5-10 00:37
发表于 2010-10-26 09:56
