干细胞分化中的重要调控信号通路：报道与实例

kephort

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+ i* M. q+ g3 V. d4 O) \对于干细胞的研究，如果不深入研究调控的话，很难有story或good idea，欢迎大家就这方面进行讨论和分析。( ?2 B5 [( j2 g
1、干细胞分化中的重要调控信号通路Wnt/beta-Catenin
' I7 ]: n) l+ X' l' _Wnt/beta-Catenin信号通路在干细胞分化、癌症发生等都有着重要作用，对这方面的重要文献和关注度高的高引用文献分享给大家。也提供了相关的全文，欢迎下载。
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' W* D1 v5 i  I! h2 r1.        MacDonald, B.T., K. Tamai, and X. He, Wnt/beta-Catenin Signaling: Components, Mechanisms, and Diseases. Developmental Cell, 2009. 17(1): p. 9-26.- _  Q, F* n3 L
2.        Michaelidis, T.M. and D.C.C. Lie, Wnt signaling and neural stem cells: caught in the Wnt web. Cell and Tissue Research, 2008. 331(1): p. 193-210.
/ R6 w2 D% z3 q8 B4 H1 C3.        Klaus, A. and W. Birchmeier, Wnt signalling and its impact on development and cancer. Nature Reviews Cancer, 2008. 8(5): p. 387-398.8 b9 y& R% f8 m! F4 L3 U/ d6 S
4.        Giles, R.H., J.H. van Es, and H. Clevers, Caught up in a Wnt storm: Wnt signaling in cancer. Biochimica Et Biophysica Acta-Reviews on Cancer, 2003. 1653(1): p. 1-24.
- D; S. B$ ?0 l% t% d5.        Polakis, P., Wnt signaling and cancer. Genes & Development, 2000. 14(15): p. 1837-1851.
' P! @! t& n5 b6 f! q) P6.        Tetsu, O. and F. McCormick, beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature, 1999. 398(6726): p. 422-426.  d/ }3 s% r8 O# q2 |
7.        Cadigan, K.M. and R. Nusse, Wnt signaling: a common theme in animal development. Genes & Development, 1997. 11(24): p. 3286-3305.' l1 X. }* y; ]( M

+ r0 Q1 s# f; }# ^七篇文献全文请在附件中下载。
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$ z$ G/ M0 D: P, Z" W7 ^  X后续的帖子中将对干细胞分化过程中的各个信号通路、表观遗传调控进行汇总。. O1 i: V/ D# `5 ?3 ]3 g
也欢迎大家发表自己的观点，补充各个regulation pathways。

痞子的烟头

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% T  s2 G/ j) ?: O. u3 e2 j谢谢海洋: i4 m% o( W$ q  }, G& C+ {) r

4 P5 U8 @1 @+ J" Y  |; W- u: c海洋注：怎么谢我了？kephort 的原创呀

jiandong2001

谢谢分享

kephort

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2、polycomb 和 trithorax（protein）在干细胞的分化及分化中的多种表观遗传修饰发挥着重要调控作用，下面是这些基因和调控信号通路相关的重要文献：
+ G! C, \- V# f+ V$ x4 K1.        Simon, J.A. and R.E. Kingston, Mechanisms of Polycomb gene silencing: knowns and unknowns. Nature Reviews Molecular Cell Biology, 2009. 10(10): p. 697-708.# B1 Q! T: ~7 ?1 G4 ]8 F
2.        Schuettengruber, B. and G. Cavalli, Recruitment of Polycomb group complexes and their role in the dynamic regulation of cell fate choice. Development, 2009. 136(21): p. 3531-3542.3 Z% m' N( y( {, G1 H! b
3.        Kerppola, T.K., Polycomb group complexes - many combinations, many functions. Trends in Cell Biology, 2009. 19(12): p. 692-704.
: P: o) P5 \5 a# K# [, E7 P4.        Schwartz, Y.B. and V. Pirrotta, Polycomb silencing mechanisms and the management of genomic programmes. Nature Reviews Genetics, 2007. 8(1): p. 9-22.: X1 {+ T4 D. A! s
5.        Schuettengruber, B., et al., Genome regulation by polycomb and trithorax proteins. Cell, 2007. 128(4): p. 735-745.
  t0 _7 s. s7 Q: y8 _6.        Sparmann, A. and M. van Lohuizen, Polycomb silencers control cell fate, development and cancer. Nature Reviews Cancer, 2006. 6(11): p. 846-856.% H! N. f* n* f7 S$ h: ?4 O
7.        Muller, J. and J.A. Kassis, Polycomb response elements and targeting of Polycomb group proteins in Drosophila. Current Opinion in Genetics & Development, 2006. 16(5): p. 476-484.% O: h) [" k! Y% `4 J  L" c6 t7 w
8.        Bracken, A.P., et al., Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions. Genes & Development, 2006. 20(9): p. 1123-1136.
' u, T* Z& H  O% [! y$ W9.        Boyer, L.A., et al., Polycomb complexes repress developmental regulators in murine embryonic stem cells. Nature, 2006. 441(7091): p. 349-353.8 x. Q& O! d8 T& g7 [3 {! [) q
10.        Bantignies, F. and G. Cavalli, Cellular memory and dynamic regulation of polycomb group proteins. Current Opinion in Cell Biology, 2006. 18(3): p. 275-283.
  m7 M( b+ |- w+ q, ^; {5 V% O: v6 W1 C11.        Levine, S.S., I.F.G. King, and R.E. Kingston, Division of labor in Polycomb group repression. Trends in Biochemical Sciences, 2004. 29(9): p. 478-485.7 R$ {0 B! J0 `0 i6 ?3 E
12.        Lessard, J. and G. Sauvageau, Polycomb group genes as epigenetic regulators of normal and leukemic hemopoiesis. Experimental Hematology, 2003. 31(7): p. 567-585.4 v* r8 }! T# p* q2 G8 T
13.        Simon, J.A. and J.W. Tamkun, Programming off and on states in chromatin: mechanisms of Polycomb and trithorax group complexes. Current Opinion in Genetics & Development, 2002. 12(2): p. 210-218.
; D3 B! c7 n4 `7 ~# `' }14.        Schumacher, A. and T. Magnuson, Murine Polycomb- and trithorax-group genes regulate homeotic pathways and beyond. Trends in Genetics, 1997. 13(5): p. 167-170.
0 S- c6 ~5 f3 Z) W1 A/ n也打包提供了全文。
$ l2 N" s* z  e& \请下载附件中的14篇全文PDF
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kephort

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欢迎大家关注、讨论细胞分化和细胞命运决定的机制。
7 L& Y+ v  g) ^6 z( P也可以就你对这方面的调控机制（细胞信号通路或表遗传修饰）、存在的问题展开讨论，谢谢！$ w6 a% Z2 u2 t& e1 R9 V* ^& Y
感兴趣的朋友不要忘了你也可以来评分的，请加包包或威望来捧场啊，本帖后续主题也全部免费下载。

show0ji3

最近也正想看看有关细胞通路的文献，谢谢您的帖子。

tspaulzhao

很好的建议，也谢谢你的分享。

lorey

谢谢分享！

Sophia

正在看信号通路方面文献，这些真是太好了，非常感谢！

dulaiyouyu

还有Notch通路。还没有像楼主一样整理多篇相关文献。呵呵。