干细胞分化中的重要调控信号通路：报道与实例

kephort

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" D' t7 Z$ P7 ~7 @* b对于干细胞的研究，如果不深入研究调控的话，很难有story或good idea，欢迎大家就这方面进行讨论和分析。
8 g. x" l8 P( L& L- _1、干细胞分化中的重要调控信号通路Wnt/beta-Catenin7 g  N8 l0 J- i
Wnt/beta-Catenin信号通路在干细胞分化、癌症发生等都有着重要作用，对这方面的重要文献和关注度高的高引用文献分享给大家。也提供了相关的全文，欢迎下载。6 x( L" i! i1 g

7 e% i8 \# ~, l" N* G1.        MacDonald, B.T., K. Tamai, and X. He, Wnt/beta-Catenin Signaling: Components, Mechanisms, and Diseases. Developmental Cell, 2009. 17(1): p. 9-26.
1 H( s0 A$ I* \2 F) L2.        Michaelidis, T.M. and D.C.C. Lie, Wnt signaling and neural stem cells: caught in the Wnt web. Cell and Tissue Research, 2008. 331(1): p. 193-210.
7 \$ o8 Q. m" f3.        Klaus, A. and W. Birchmeier, Wnt signalling and its impact on development and cancer. Nature Reviews Cancer, 2008. 8(5): p. 387-398.. ]% S/ o, S4 B; z7 X. D
4.        Giles, R.H., J.H. van Es, and H. Clevers, Caught up in a Wnt storm: Wnt signaling in cancer. Biochimica Et Biophysica Acta-Reviews on Cancer, 2003. 1653(1): p. 1-24.
2 P, }5 X6 V1 y, ~; l( Y5 K5.        Polakis, P., Wnt signaling and cancer. Genes & Development, 2000. 14(15): p. 1837-1851.
3 k$ g9 Z4 L, U, }& q) i6.        Tetsu, O. and F. McCormick, beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature, 1999. 398(6726): p. 422-426.
0 u) H9 o3 }) d% [) r" V) R8 U8 @! g. o7.        Cadigan, K.M. and R. Nusse, Wnt signaling: a common theme in animal development. Genes & Development, 1997. 11(24): p. 3286-3305.: m; M4 M# [$ I" p6 m# B
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七篇文献全文请在附件中下载。
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8 }! F9 t8 P* v后续的帖子中将对干细胞分化过程中的各个信号通路、表观遗传调控进行汇总。! [, U/ Z8 j% R+ Y/ B1 I7 B2 J" O
也欢迎大家发表自己的观点，补充各个regulation pathways。

痞子的烟头

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谢谢海洋" b. z  I2 w: h( r
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海洋注：怎么谢我了？kephort 的原创呀

jiandong2001

谢谢分享

kephort

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& r) G4 Y; w' s! ^2、polycomb 和 trithorax（protein）在干细胞的分化及分化中的多种表观遗传修饰发挥着重要调控作用，下面是这些基因和调控信号通路相关的重要文献：
8 V' Q6 V3 u" N1.        Simon, J.A. and R.E. Kingston, Mechanisms of Polycomb gene silencing: knowns and unknowns. Nature Reviews Molecular Cell Biology, 2009. 10(10): p. 697-708.5 v4 g  k' a% V) i9 G
2.        Schuettengruber, B. and G. Cavalli, Recruitment of Polycomb group complexes and their role in the dynamic regulation of cell fate choice. Development, 2009. 136(21): p. 3531-3542.
4 t, A: E9 c: E% k. ]3.        Kerppola, T.K., Polycomb group complexes - many combinations, many functions. Trends in Cell Biology, 2009. 19(12): p. 692-704.. x9 Y* Y' e& B" S- k1 S9 B' @
4.        Schwartz, Y.B. and V. Pirrotta, Polycomb silencing mechanisms and the management of genomic programmes. Nature Reviews Genetics, 2007. 8(1): p. 9-22.
! q- A* l/ j& \6 x8 t5.        Schuettengruber, B., et al., Genome regulation by polycomb and trithorax proteins. Cell, 2007. 128(4): p. 735-745.6 t+ \$ |" m' |5 G9 [1 S
6.        Sparmann, A. and M. van Lohuizen, Polycomb silencers control cell fate, development and cancer. Nature Reviews Cancer, 2006. 6(11): p. 846-856.
  s; ^( d3 y# A) {9 M7.        Muller, J. and J.A. Kassis, Polycomb response elements and targeting of Polycomb group proteins in Drosophila. Current Opinion in Genetics & Development, 2006. 16(5): p. 476-484.; q, ?! V# ~+ B* G' N! g0 D
8.        Bracken, A.P., et al., Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions. Genes & Development, 2006. 20(9): p. 1123-1136.
7 J) M2 c- \2 z5 e9.        Boyer, L.A., et al., Polycomb complexes repress developmental regulators in murine embryonic stem cells. Nature, 2006. 441(7091): p. 349-353.4 Z+ j( L, ~" }) r# {. d
10.        Bantignies, F. and G. Cavalli, Cellular memory and dynamic regulation of polycomb group proteins. Current Opinion in Cell Biology, 2006. 18(3): p. 275-283.
2 i3 b3 d1 e7 s+ @" O11.        Levine, S.S., I.F.G. King, and R.E. Kingston, Division of labor in Polycomb group repression. Trends in Biochemical Sciences, 2004. 29(9): p. 478-485.
2 [2 G  ?6 _+ l* u  k& f12.        Lessard, J. and G. Sauvageau, Polycomb group genes as epigenetic regulators of normal and leukemic hemopoiesis. Experimental Hematology, 2003. 31(7): p. 567-585.
+ ?- ~! G# z3 a3 S13.        Simon, J.A. and J.W. Tamkun, Programming off and on states in chromatin: mechanisms of Polycomb and trithorax group complexes. Current Opinion in Genetics & Development, 2002. 12(2): p. 210-218.; n4 N" M, P, a& }& J
14.        Schumacher, A. and T. Magnuson, Murine Polycomb- and trithorax-group genes regulate homeotic pathways and beyond. Trends in Genetics, 1997. 13(5): p. 167-170.
9 V" ^1 p" ~, g% g( M也打包提供了全文。
& I' }: L  A# g& R' `( Y请下载附件中的14篇全文PDF0 c6 ^! G+ t& t! x; q) K- P

kephort

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欢迎大家关注、讨论细胞分化和细胞命运决定的机制。
$ i2 Y$ C! t+ P% |% }也可以就你对这方面的调控机制（细胞信号通路或表遗传修饰）、存在的问题展开讨论，谢谢！0 g( D! M) u" ^, w# Y
感兴趣的朋友不要忘了你也可以来评分的，请加包包或威望来捧场啊，本帖后续主题也全部免费下载。

show0ji3

最近也正想看看有关细胞通路的文献，谢谢您的帖子。

tspaulzhao

很好的建议，也谢谢你的分享。

lorey

谢谢分享！

Sophia

正在看信号通路方面文献，这些真是太好了，非常感谢！

dulaiyouyu

还有Notch通路。还没有像楼主一样整理多篇相关文献。呵呵。