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本帖最后由 细胞海洋 于 2010-5-21 06:54 编辑 5 \# E6 n6 A# j; A; N" O& w
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李凌松*，王 莉
- z9 A/ ~8 n1 a（北京大学干细胞研究中心细胞生物学系，北京 100871）
2 F/ i0 d' _: g( W- O k摘 要：胚胎干细胞具有自我复制并分化为人体各种功能细胞的潜能。胚胎干细胞具有的独特生物学6 n/ B$ _: u2 i* P" b
特性使其被广泛应用于生物学研究的各个领域，特别是发育学。同时，它潜在的医学应用也成为世界1 o/ G) ~2 `2 F$ w B1 M. {
范围内的研究热点。但是，由于人胚胎干细胞的来源为植入前的早期胚胎，人胚胎干细胞自诞生之日2 X! A( P/ S. r& d+ B. [
起便倍受争议。本文将从胚胎干细胞的来源、特性、鉴定标准、增殖机理、应用前景以及研究本身
: t" Y, W$ J+ M8 V" s涉及的伦理学争论给予概述。& @$ |# @ V( o& b
关键词：胚胎干细胞；自我更新；分化；鉴定；胚胎生殖细胞；应用0 }" c, f/ z$ U- e% I
中图分类号：Q813 文献标识码：A, o: a Y# Z, \$ O1 a
Embryonic stem cells, Q- G, q) s+ f! g4 ?
LI Ling-Song*, WANG Li
7 w' M1 B6 E8 T6 n# h5 ](Department of Cell Biology, Stem Cell Research Center, Peking University, Beijing 100871)7 |8 }) ?% p3 |7 c! x8 z0 }% g% s
Abstract: Embryonic stem (ES) cells are able to self-renew and differentiate into all kinds of human cells. Due to
/ h0 d& e. V$ ^- Vtheir unique properties, ES cells are used in diverse fields of biological research，particular in developmental, G% j7 t3 Y8 {% T+ }
biology. Meanwhile, their potential medical application become a research hot-spot worldwidly. Since preimplantation
2 p4 M2 Q, Y6 n. m; yeggs are sources to generate ES cells, the use of embryonic stem cells is therefore controversial.
O8 Q1 o( E# ^, D4 a5 hThis review will outline characterization of ES cells, regulation of self-renewal, and the applications of the cell7 u3 r6 N, N5 s
in treating diseases, as well as ethical issues related to human ES cells research.
4 M! i; M0 @# U: M5 l! Q& F' oKey words: embryonic stem cells; self-renewal; differentiation; characterization; embryonic germ cells;
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发表于 2009-2-27 10:29
发表于 2009-7-14 15:44
