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本帖最后由 细胞海洋 于 2010-5-21 06:54 编辑
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李凌松*，王 莉
7 p) E* X# r6 J, ~2 w7 ]8 I（北京大学干细胞研究中心细胞生物学系，北京 100871）/ y5 @2 U/ q0 \; X" ]$ q* ?
摘 要：胚胎干细胞具有自我复制并分化为人体各种功能细胞的潜能。胚胎干细胞具有的独特生物学
9 r2 J) V0 ~( }2 B特性使其被广泛应用于生物学研究的各个领域，特别是发育学。同时，它潜在的医学应用也成为世界
/ ]* [4 }9 v: B) w( @& o5 j2 a范围内的研究热点。但是，由于人胚胎干细胞的来源为植入前的早期胚胎，人胚胎干细胞自诞生之日0 r! w: ]+ P3 t' \# ~2 ?! X
起便倍受争议。本文将从胚胎干细胞的来源、特性、鉴定标准、增殖机理、应用前景以及研究本身
$ v& G" G: L+ r8 J" e9 L涉及的伦理学争论给予概述。
; O$ m5 T2 s5 @/ d# k关键词：胚胎干细胞；自我更新；分化；鉴定；胚胎生殖细胞；应用3 T, X0 |" J% w( a' Y
中图分类号：Q813 文献标识码：A
5 `: |! ^' q0 y8 X) \7 GEmbryonic stem cells8 O' v4 H4 m" `! F7 F9 I. Q
LI Ling-Song*, WANG Li* X3 c5 x1 a3 |. ?: W' M+ ?2 w
(Department of Cell Biology, Stem Cell Research Center, Peking University, Beijing 100871)
: W+ d% v# o3 S3 [! |% rAbstract: Embryonic stem (ES) cells are able to self-renew and differentiate into all kinds of human cells. Due to" A( f9 T; O2 b! c- c3 X2 f; n
their unique properties, ES cells are used in diverse fields of biological research，particular in developmental
4 ~, V1 a# I* G5 ^: H) _biology. Meanwhile, their potential medical application become a research hot-spot worldwidly. Since preimplantation' {; F! l6 E6 Z5 _" z6 V
eggs are sources to generate ES cells, the use of embryonic stem cells is therefore controversial.
; [7 j; N" r5 ?, s x0 J/ PThis review will outline characterization of ES cells, regulation of self-renewal, and the applications of the cell; V+ i2 B& ]" }2 E9 I" p
in treating diseases, as well as ethical issues related to human ES cells research.: M! X$ Z2 X; w) t6 t, u
Key words: embryonic stem cells; self-renewal; differentiation; characterization; embryonic germ cells;
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发表于 2009-2-27 10:29
发表于 2009-7-14 15:44
