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本帖最后由 细胞海洋 于 2010-5-21 06:54 编辑
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2 ^3 a+ |5 [/ O李凌松*，王 莉3 m, W+ @" l% Y
（北京大学干细胞研究中心细胞生物学系，北京 100871）
; E2 J% J! M5 N( r k摘 要：胚胎干细胞具有自我复制并分化为人体各种功能细胞的潜能。胚胎干细胞具有的独特生物学; o5 j: S. j- U6 H+ t4 h% l
特性使其被广泛应用于生物学研究的各个领域，特别是发育学。同时，它潜在的医学应用也成为世界! a3 r! O6 A- H1 h+ c2 Z
范围内的研究热点。但是，由于人胚胎干细胞的来源为植入前的早期胚胎，人胚胎干细胞自诞生之日( P5 t6 F& C$ j( Y: G3 s% |% N" D' d7 y
起便倍受争议。本文将从胚胎干细胞的来源、特性、鉴定标准、增殖机理、应用前景以及研究本身
1 M+ ~" w* u8 o$ A- l涉及的伦理学争论给予概述。
( {7 q3 z3 {8 K" _% R4 w关键词：胚胎干细胞；自我更新；分化；鉴定；胚胎生殖细胞；应用
: t( X# F' d) Q2 ^% {! f% F/ `中图分类号：Q813 文献标识码：A
, V" p- H: o$ f- c) N. K9 j2 A3 l8 ^3 OEmbryonic stem cells
; ^2 L+ j' h* Y5 s3 o4 E- BLI Ling-Song*, WANG Li
1 y% d( a9 C( P7 F(Department of Cell Biology, Stem Cell Research Center, Peking University, Beijing 100871)
3 M7 W' |2 p" Q, o* f$ G% P* f+ S+ @Abstract: Embryonic stem (ES) cells are able to self-renew and differentiate into all kinds of human cells. Due to, \# K, z0 g, b9 X: Q
their unique properties, ES cells are used in diverse fields of biological research，particular in developmental3 [8 N* {/ r3 d! ?2 S, z4 ~3 y
biology. Meanwhile, their potential medical application become a research hot-spot worldwidly. Since preimplantation0 W& W- v7 Z5 g a4 W( Z8 q
eggs are sources to generate ES cells, the use of embryonic stem cells is therefore controversial., e) L4 E7 s% a+ c& x$ F
This review will outline characterization of ES cells, regulation of self-renewal, and the applications of the cell
( d- l$ u+ j; M: h5 Q+ R4 Z9 }- gin treating diseases, as well as ethical issues related to human ES cells research.
( }4 L& V+ p% b5 iKey words: embryonic stem cells; self-renewal; differentiation; characterization; embryonic germ cells;
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