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本帖最后由 细胞海洋 于 2010-5-21 06:54 编辑
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李凌松*，王 莉
! @0 N3 E2 i: G3 V# `7 f（北京大学干细胞研究中心细胞生物学系，北京 100871）' s# t; x. q, @% A$ s x" X3 B
摘 要：胚胎干细胞具有自我复制并分化为人体各种功能细胞的潜能。胚胎干细胞具有的独特生物学1 J$ w' v) [) @" G2 y" p
特性使其被广泛应用于生物学研究的各个领域，特别是发育学。同时，它潜在的医学应用也成为世界
$ l7 U4 L. l# H范围内的研究热点。但是，由于人胚胎干细胞的来源为植入前的早期胚胎，人胚胎干细胞自诞生之日
( z4 _% z5 U- \$ {起便倍受争议。本文将从胚胎干细胞的来源、特性、鉴定标准、增殖机理、应用前景以及研究本身
3 I/ y2 |( Z8 h9 Z" s涉及的伦理学争论给予概述。
0 T( y6 ~) Q. F. O9 \- Z关键词：胚胎干细胞；自我更新；分化；鉴定；胚胎生殖细胞；应用0 k9 m( J6 Y: A+ c8 R% W
中图分类号：Q813 文献标识码：A3 v5 @% Z) D1 P6 t& o9 T
Embryonic stem cells
- K! _$ H" n1 k4 x& k: j6 ~LI Ling-Song*, WANG Li
6 r2 ~7 t' r+ B- f7 W$ H. b(Department of Cell Biology, Stem Cell Research Center, Peking University, Beijing 100871)
2 g G% U- n3 P' u. b" u1 ^Abstract: Embryonic stem (ES) cells are able to self-renew and differentiate into all kinds of human cells. Due to
& f3 ?) J; r' s% H7 Otheir unique properties, ES cells are used in diverse fields of biological research，particular in developmental* Q. Y: s# F7 G: Y; X8 I& `3 R1 ~" c
biology. Meanwhile, their potential medical application become a research hot-spot worldwidly. Since preimplantation
5 [. S9 ~1 R1 o; N, U. Ceggs are sources to generate ES cells, the use of embryonic stem cells is therefore controversial.
" H# U" Z( e" V& |This review will outline characterization of ES cells, regulation of self-renewal, and the applications of the cell, R$ u, U; ]5 q+ f8 ]4 B5 j! S
in treating diseases, as well as ethical issues related to human ES cells research.! u4 t3 U& M) V, [; Y
Key words: embryonic stem cells; self-renewal; differentiation; characterization; embryonic germ cells;
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发表于 2009-2-27 10:29
发表于 2009-7-14 15:44
