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本帖最后由 细胞海洋 于 2010-5-21 06:54 编辑 0 P# b _. e+ G) W! D
4 X8 F# F* `: W( X) Y# m李凌松*，王 莉 M0 I2 M: V+ e$ s, C2 ?
（北京大学干细胞研究中心细胞生物学系，北京 100871） O2 j7 o( s" r" S% s8 @: h, H
摘 要：胚胎干细胞具有自我复制并分化为人体各种功能细胞的潜能。胚胎干细胞具有的独特生物学
, y. H9 m2 j2 ^7 H4 e! A特性使其被广泛应用于生物学研究的各个领域，特别是发育学。同时，它潜在的医学应用也成为世界, }& T1 b% I4 t& N$ b: Y( B# s$ S8 C0 Q
范围内的研究热点。但是，由于人胚胎干细胞的来源为植入前的早期胚胎，人胚胎干细胞自诞生之日
1 A6 s% k5 l) v5 B/ O3 N3 X0 v" y起便倍受争议。本文将从胚胎干细胞的来源、特性、鉴定标准、增殖机理、应用前景以及研究本身0 y+ J+ J) ]3 o* U3 G
涉及的伦理学争论给予概述。
+ d; Y9 J. t# D( c% ^9 J i关键词：胚胎干细胞；自我更新；分化；鉴定；胚胎生殖细胞；应用
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Embryonic stem cells! ?! P! N8 ~( G
LI Ling-Song*, WANG Li+ b& B: R" m) p, M
(Department of Cell Biology, Stem Cell Research Center, Peking University, Beijing 100871)
) E% u2 J6 `( C2 j8 c+ K2 tAbstract: Embryonic stem (ES) cells are able to self-renew and differentiate into all kinds of human cells. Due to
, v+ \! z0 J7 o/ Itheir unique properties, ES cells are used in diverse fields of biological research，particular in developmental9 i9 C; c+ X4 ^( H
biology. Meanwhile, their potential medical application become a research hot-spot worldwidly. Since preimplantation7 a! E* n- X0 ~ q/ T: r
eggs are sources to generate ES cells, the use of embryonic stem cells is therefore controversial.1 E% ]( ]; Q! ~9 q, N" [3 Q
This review will outline characterization of ES cells, regulation of self-renewal, and the applications of the cell" r4 s# w4 j" [3 ~: M
in treating diseases, as well as ethical issues related to human ES cells research.5 ~: y' E5 O- U8 U4 |
Key words: embryonic stem cells; self-renewal; differentiation; characterization; embryonic germ cells;+ }! n8 m; d1 ^: i/ {
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发表于 2009-2-27 10:29
发表于 2009-7-14 15:44
