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本帖最后由 细胞海洋 于 2010-5-21 06:54 编辑 7 k* a7 C- N3 S! x+ y1 ?
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李凌松*，王 莉7 w# ^$ i( l/ {
（北京大学干细胞研究中心细胞生物学系，北京 100871）
+ r& o4 Q: u( t2 ]- ]摘 要：胚胎干细胞具有自我复制并分化为人体各种功能细胞的潜能。胚胎干细胞具有的独特生物学
' Z: C4 h0 a s6 h5 c特性使其被广泛应用于生物学研究的各个领域，特别是发育学。同时，它潜在的医学应用也成为世界8 s! d; T. o+ `+ f% t1 F2 c: @
范围内的研究热点。但是，由于人胚胎干细胞的来源为植入前的早期胚胎，人胚胎干细胞自诞生之日
: U) F C2 o4 e起便倍受争议。本文将从胚胎干细胞的来源、特性、鉴定标准、增殖机理、应用前景以及研究本身: |! ]7 ]( @% W# k. E- |7 W3 d
涉及的伦理学争论给予概述。* t5 V2 r6 @! [9 V. n3 ]
关键词：胚胎干细胞；自我更新；分化；鉴定；胚胎生殖细胞；应用
7 o8 f) I1 v+ s6 ^: z |中图分类号：Q813 文献标识码：A
6 @* u0 W, L0 @% l* F7 SEmbryonic stem cells, @0 Z3 r) }. r6 w. X7 c! @8 W0 x
LI Ling-Song*, WANG Li- Z; \( x8 I! ~7 z
(Department of Cell Biology, Stem Cell Research Center, Peking University, Beijing 100871)! V4 @/ h2 u+ ^- P0 k @
Abstract: Embryonic stem (ES) cells are able to self-renew and differentiate into all kinds of human cells. Due to
2 O- x4 }8 n* _) B' n& ]% ?7 Ytheir unique properties, ES cells are used in diverse fields of biological research，particular in developmental, A; z( L8 o. n9 D7 Y
biology. Meanwhile, their potential medical application become a research hot-spot worldwidly. Since preimplantation' x+ k% N5 n. s/ s2 D- ? _
eggs are sources to generate ES cells, the use of embryonic stem cells is therefore controversial.; \" @& G% V1 [! u* U
This review will outline characterization of ES cells, regulation of self-renewal, and the applications of the cell
6 k# e$ U6 T) Win treating diseases, as well as ethical issues related to human ES cells research.
; m% Z$ }& t/ ], O2 ]" ^+ ?Key words: embryonic stem cells; self-renewal; differentiation; characterization; embryonic germ cells;) [1 ~! i' O1 P; i0 m' t
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发表于 2009-2-27 10:29
发表于 2009-7-14 15:44
