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本帖最后由 细胞海洋 于 2010-5-21 06:54 编辑
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李凌松*，王 莉
4 s7 [6 X* t$ y. M2 [5 X! l, j（北京大学干细胞研究中心细胞生物学系，北京 100871）
" }% H3 h4 x, g$ _摘 要：胚胎干细胞具有自我复制并分化为人体各种功能细胞的潜能。胚胎干细胞具有的独特生物学
; D* \/ x2 c9 ^特性使其被广泛应用于生物学研究的各个领域，特别是发育学。同时，它潜在的医学应用也成为世界
9 a7 F* O) v: O: K* U$ m范围内的研究热点。但是，由于人胚胎干细胞的来源为植入前的早期胚胎，人胚胎干细胞自诞生之日
/ e/ }- C/ `' a起便倍受争议。本文将从胚胎干细胞的来源、特性、鉴定标准、增殖机理、应用前景以及研究本身
1 S0 p A7 t4 C) |+ ^0 `6 w涉及的伦理学争论给予概述。5 K8 I: {/ M/ v
关键词：胚胎干细胞；自我更新；分化；鉴定；胚胎生殖细胞；应用
- x0 ^& v2 I# m% t中图分类号：Q813 文献标识码：A
$ x: K! O& F; q% r3 I! uEmbryonic stem cells
, }1 f& [. u( k8 d0 q" {# GLI Ling-Song*, WANG Li, M V# D! w+ G: O. h) A
(Department of Cell Biology, Stem Cell Research Center, Peking University, Beijing 100871)2 J( D0 i* e9 v4 `. k
Abstract: Embryonic stem (ES) cells are able to self-renew and differentiate into all kinds of human cells. Due to% j% T+ N9 S" R8 \4 c; l
their unique properties, ES cells are used in diverse fields of biological research，particular in developmental
' z: c( u) v& u- Q9 Rbiology. Meanwhile, their potential medical application become a research hot-spot worldwidly. Since preimplantation$ T' L8 }1 ]/ |
eggs are sources to generate ES cells, the use of embryonic stem cells is therefore controversial." m9 W- |% n; _2 Z
This review will outline characterization of ES cells, regulation of self-renewal, and the applications of the cell
7 |9 t4 Z8 N) B r2 B" `in treating diseases, as well as ethical issues related to human ES cells research.- [( X4 F" K4 a1 g D, C+ y" K
Key words: embryonic stem cells; self-renewal; differentiation; characterization; embryonic germ cells;! `& G, z+ Z" O; r
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发表于 2009-2-27 10:29
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