干细胞、肿瘤干细胞与肿瘤发生

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' o$ D" C8 Y; T' k钱波, 蔡寒青, 冯洁, 中国医学科学院中国协和医科大学研$ l0 B8 J" e( o7 q# V- M# b- l
究生院 北京市 100730
# b" e* q) h2 }8 S  y- u4 u通讯作者: 钱波, 100029, 北京市朝阳区樱花东街 2 号, 中国医学
0 D- {# \$ I! \- K- O: F" I. J科学院中国协和医科大学中日临床研究所. qianbo79@163.com
  J1 Z1 X( ?# |: Q$ S电话: 010-84206005 传真: 010-64206643- {# L% l! I- O: ]
收稿日期: 2007-03-17 接受日期: 2007-04-25% y* _3 V1 i" l7 ^
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Association of stem cells5 R3 |8 a" W+ M) Q8 c
and cancer stem cells with6 d% j. z4 U1 O( k! P+ x- _
tumorigenesis" p1 m5 R! C% P8 ]& L$ S! x
Bo Qian, Han-Qing Cai, Jie Feng
  N' k9 g) ~& l. V' l6 u1 tBo Qian, Han-Qing Cai, Jie Feng, Postgraduate School of" g3 p1 [( H# L6 s7 M2 |0 s# T" Q% S
Peking Union Medical College, Chinese Academy of Medical
: F( \$ y) k/ d/ BSciences, Beijing 100730, China6 k# z0 k! J& ?( Y4 O) j. S
Correspondence to: Bo Qian, China-Japan Clinical Research% ?' |. o$ h6 q8 |0 H0 l; a
Institute, Peking Union Medical College, Chinese
7 p2 ?, @! E3 A! f7 j) ^7 @) BAcademy of Medical Sciences, 2 Yinghua East Street, Beijing4 W6 \, ]# i2 X9 K( m% j2 S# a
100029, China. qianbo79@163.com8 I8 [% K& e( g  q
Received: 2007-03-17 Accepted: 2007-04-25% k2 Y# k# L/ S9 \
Abstract, Y0 d' y( F6 o- L
The research on cancer stem cells is a new hot0 Y& I$ X, T, k! @0 g
spot in at present. The hypothesis indicates
' _/ d6 w6 n- F' q; qcancer stem cells, which were possibly the origin, _' {  W7 m- m1 N* b  \& a# F/ U
of the cancer, come from normal stem cells. For3 r4 W+ v" }) t+ P7 E. H  f( ~
their special characters, normal stem cells can
5 S1 e% Q3 T& z, u' `0 s) J* _differentiate into tumor cells more easily than
4 C3 {1 W" ]5 y, ^% s6 W% oadult cells. Stem cells transform into malignant
/ z; U$ G  l. @/ ocancer stem cells possibly because of gene5 E6 S6 c- r# C: ^/ {' r5 C7 u
mutation, abnormal asymmetry and cell fusion.+ j" r* k5 X9 Z0 p4 q
It is a main method to obtain cancer stem cells by! Z  D, v! j; i
flow cytometer using different protein markers
" `+ B$ D/ v' T/ v/ Qand fluorescent probes. It is demonstrated that
( D, ?5 Z0 Q" J8 ecancer stem cells are very powerful in selfrenewal,( p# Q& @. H5 x9 F6 P
proliferation, and differentiation.
1 C2 D2 t& n* ATargeting on cancer stem cells, early diagnosis
* o7 t, d+ X2 u; Efor cancers might be achieved.
8 I0 J5 v; P4 P* e! m& jKey Words: Stem cell; Cancer stem cell; Cell differentiation;
( T8 @# g  G  A( p1 t2 r& vTumorigenesis; Flow cytometer0 m4 m1 T! I$ h) a
Qian B, Cai HQ, Feng J. Association of stem cells and
! S7 O& K! a/ ?cancer stem cells with tumorigenesis. Shijie Huaren
, o/ X4 M/ L1 wXiaohua Zazhi 2007;15(13):1526-1531
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6 c% f# a8 U4 t) v% D摘要
/ g' j* S8 R# \( g肿瘤干细胞是肿瘤研究的一个新热点, 指出肿瘤可能是由肿瘤干细胞产生, 肿瘤干细胞则
, N/ F" i/ p$ J$ ~' @由正常干细胞恶变形成. 正常干细胞的特有性
& d9 L: x, j# b9 H- e; D! D1 x状, 使其较成体细胞更易成为肿瘤发生的靶细' l7 F+ ]2 i. o$ o# b( N: [
胞. 干细胞可能经基因突变、异常不对称分裂/ v# _! U9 ~! |
和细胞融合转化为肿瘤干细胞. 利用不同的蛋
5 b! R* Q3 z% p白标志物或荧光探针, 通过流式细胞仪分选是3 `0 F  Z7 G/ p
发现肿瘤干细胞的主要方法. 已证实的肿瘤干! ]3 g, o/ N5 z( _6 o
细胞皆具有强大的自我更新和增殖能力, 以及5 L0 ~  G. [4 m4 d  d: R, Z( T
细胞分化潜能. 针对肿瘤干细胞的检测和杀
. u" a$ @$ L* B- S) ^4 B: Y# x伤, 可能为肿瘤早期诊断和治疗带来希望.) g. @8 B% E" s7 y3 `; x
关键词: 干细胞; 肿瘤干细胞; 细胞分化; 肿瘤发生;
9 \- {# b/ Z5 v1 v( J- \流式细胞仪
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) }4 Y' ?6 G  `3 d附件为pdf全文，请大家支持一下 回复本贴就可以下载了1 C( U" d$ o" p2 c4 g" W5 f1 ]4 Y

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jitianxing7021

楼主辛苦了！太感激了！多顶顶！您正在看的文章来自干细胞之家 http://www.stemcell8.com/,原文地址:http://www.stemcell8.com/viewthread.php?tid=2252

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