干细胞、肿瘤干细胞与肿瘤发生

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钱波, 蔡寒青, 冯洁, 中国医学科学院中国协和医科大学研
9 ~( R( \6 o: l* I! n( _究生院 北京市 100730
, J$ C; o% v+ p通讯作者: 钱波, 100029, 北京市朝阳区樱花东街 2 号, 中国医学9 ]( O3 C& ]5 `
科学院中国协和医科大学中日临床研究所. qianbo79@163.com
( c: g4 X8 M1 c/ D- G0 g% u' Y4 n电话: 010-84206005 传真: 010-64206643
( K8 \4 E, y2 {1 c& I; A( H. G* }收稿日期: 2007-03-17 接受日期: 2007-04-25: g" s: v4 O; `4 ^. e

# e+ r" w0 w, q) R! ?5 WAssociation of stem cells
4 V; ^" X/ s- i9 }6 l( q+ F3 ]and cancer stem cells with
3 N1 ~6 x9 J' D# M3 C; ztumorigenesis
( M- z* d7 s; [, A" [- w) uBo Qian, Han-Qing Cai, Jie Feng
$ Z/ N8 F. K7 j) Y1 oBo Qian, Han-Qing Cai, Jie Feng, Postgraduate School of" Y& i( }7 z' M5 d+ [1 f
Peking Union Medical College, Chinese Academy of Medical9 j4 f! i4 b3 J+ ~5 B/ J
Sciences, Beijing 100730, China- H9 p2 Y" _% \, @- v
Correspondence to: Bo Qian, China-Japan Clinical Research7 h4 g, F" D2 I' m& u# M3 d$ o, P1 f
Institute, Peking Union Medical College, Chinese
5 t' P7 L! r( q7 ^Academy of Medical Sciences, 2 Yinghua East Street, Beijing
& L! q4 \/ C$ w& A/ P100029, China. qianbo79@163.com! ]4 Q  b3 D- V3 Q4 l" U8 j
Received: 2007-03-17 Accepted: 2007-04-25% c  a2 M7 N( P
Abstract% _: ]7 b& S+ i$ M
The research on cancer stem cells is a new hot1 i8 T2 e3 S( h* E8 E* d* V
spot in at present. The hypothesis indicates" J1 B3 M" {7 c& p+ n" `8 _
cancer stem cells, which were possibly the origin! s1 B& a5 w3 s% x4 s. U0 Y1 k
of the cancer, come from normal stem cells. For0 u8 t2 S2 _+ y7 J: L5 x' c* u5 v1 k
their special characters, normal stem cells can  B" V) ~) h+ S
differentiate into tumor cells more easily than0 [; p! H; n3 C$ v7 v; F) O( [* U; {
adult cells. Stem cells transform into malignant
1 j( L' O, b# ^: l' rcancer stem cells possibly because of gene; N, P5 E1 D1 D$ V& s+ |3 V5 K
mutation, abnormal asymmetry and cell fusion.8 t  K' s1 l1 R: N# G# i
It is a main method to obtain cancer stem cells by0 J, a5 ]4 t& H! k5 q1 y
flow cytometer using different protein markers3 x& ?* }" o6 b
and fluorescent probes. It is demonstrated that
7 L7 H6 z! R: ~, \3 c! X- |cancer stem cells are very powerful in selfrenewal,
5 F' x( d' V  j. M- [$ n, {proliferation, and differentiation.' |  z% V* g7 M5 J) A* A
Targeting on cancer stem cells, early diagnosis
2 L7 j. [2 o: f/ pfor cancers might be achieved.+ R* v3 [% }5 p2 @/ e( `
Key Words: Stem cell; Cancer stem cell; Cell differentiation;
  ]2 P$ B! G! h" XTumorigenesis; Flow cytometer/ E& S' r* G! N. a* N
Qian B, Cai HQ, Feng J. Association of stem cells and' n, B$ {  j5 d1 M3 u
cancer stem cells with tumorigenesis. Shijie Huaren" L' F2 }9 ^/ J% p$ Y8 ~0 _8 z
Xiaohua Zazhi 2007;15(13):1526-1531
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- l3 I% _+ ?! I摘要
" [' ^  l! ]. ?肿瘤干细胞是肿瘤研究的一个新热点, 指出肿瘤可能是由肿瘤干细胞产生, 肿瘤干细胞则
' J/ d2 x. j1 b/ x& _9 F由正常干细胞恶变形成. 正常干细胞的特有性
# `% U0 Y" Y, B8 C5 _状, 使其较成体细胞更易成为肿瘤发生的靶细
$ D. ?; l+ c& [0 n" K5 \胞. 干细胞可能经基因突变、异常不对称分裂
* U% s4 U$ M9 _5 r5 S和细胞融合转化为肿瘤干细胞. 利用不同的蛋% T2 I# F8 I7 N* U9 F- [8 a/ V6 @" S
白标志物或荧光探针, 通过流式细胞仪分选是6 i3 u4 E2 T8 W
发现肿瘤干细胞的主要方法. 已证实的肿瘤干
  ?, j! y0 ]* w  f. |0 F细胞皆具有强大的自我更新和增殖能力, 以及% E6 b+ U0 t7 l* ^1 S/ i6 k% a" I
细胞分化潜能. 针对肿瘤干细胞的检测和杀
7 R% Q/ B5 v9 m; ?* m伤, 可能为肿瘤早期诊断和治疗带来希望.8 U% R+ r+ I4 T* ^( u3 G) [' o
关键词: 干细胞; 肿瘤干细胞; 细胞分化; 肿瘤发生;% U5 I- b. N5 m* C1 ]0 F
流式细胞仪2 e, }! [6 s3 |) D2 g% l1 b  d& Y+ @

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jitianxing7021

楼主辛苦了！太感激了！多顶顶！您正在看的文章来自干细胞之家 http://www.stemcell8.com/,原文地址:http://www.stemcell8.com/viewthread.php?tid=2252

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