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Liver cirrhosis (LC) is the end stage of chronic liver disease and
' F4 d" s5 Q/ C. ^is very difficult to treat. Currently, liver transplantation is one of+ }$ m9 n: k7 N
the only effective therapies available to such patients. However,
' l! p2 Y/ @" J' l/ E# P jserious problems are associated with liver transplantation: lack# i6 C) S2 W+ F6 w6 t
of donors, surgical complications, rejection, and high cost. Regenerative
7 q! H" {( u6 u! W& Ftherapies have the potential to provide minimally
" {( u3 |5 C: minvasive procedures with few complications.
( a) J: ^( R; K y% q [The potential for stem cells in bone marrow (BM) to differentiate
1 ~) H: h, e% _+ O+ x" \# ninto hepatocytes and intestinal cells was recently confirmed/ I- z, B1 t# m! K6 }$ E8 s/ m- n
through detection of Y chromosome-containing cells in$ `" W9 x! ~* `( d2 W- i8 ~
samples from female recipients of BM cells (BMCs) from male3 d$ u8 O; J* C. y$ C2 Y. z
donors [1–3]. BMC transplantation has been performed to treat
5 m0 w! f; [" \% M3 j F# v; n7 |hematological diseases, and several clinical studies have applied
( t1 T6 S, Z5 Q+ [2 zBMC injection to induce regeneration of myocardium and blood: h+ G; e( N/ `% B B
vessels [4]. Taken together, these findings suggest that BMCs2 F; b+ G5 `+ J# |# G
are effective sources for regenerative liver therapy. |
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发表于 2010-6-21 19:07
