《细胞》[cell]2010年8月20出版pdf全文

scienese

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封面介绍On the cover: Cachexia or muscle wasting affects many cancer patients, particularly those with late-stage disease. In this issue, Zhou et al. (pp. 531–543) demonstrate that blocking the ActRIIB signaling pathway with a decoy receptor in several mouse models of cancer boosts muscle mass and prolongs survival even without slowing tumor growth. This treatment reduces the breakdown of muscle proteins by the ubiquitin-proteasome pathway and stimulates proliferation of muscle satellite (stem) cells. The painting on the cover illustrates the dramatic increase in muscle mass and improved quality of life for a tumor-bearing mouse with cachexia after treatment with the decoy receptor. Illustration by David G. Evans; Surfmedia Enterprises, LLC.; }: f7 w+ x, D! _2 F& r
好可爱的小鼠O(∩_∩)O哈，超喜欢~~, j! A8 }+ x5 z4 `! ^3 `$ G

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In This Issue p497
5 B! U* l4 R/ r/ \; [" i( Y) y0 }2 d- RFull Text | PDF (273 kb)
- J- ^# R" {: |" v; \Cell Culture p501
8 O; K. j) W% c9 d" W3 CSummary | Full Text | PDF (258 kb)
6 g  [1 }4 G0 s  R/ N( S2 q9 TEssay
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# P+ ~1 ~9 _" g& d7 }2 I; V. mInduced Domain Formation in Endocytic Invagination, Lipid Sorting, and Scission p507
. w% y9 e( t( ]3 ]) i( y7 n8 j- V6 ?7 ULudger Johannes, Satyajit Mayor4 \- V9 z* _7 f  C& }9 f" ~
Summary | Full Text | PDF (450 kb)
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Reversing Cachexia p511, D+ t: J7 d; W5 [+ I
Michael J. Tisdale  N6 |: ~6 x( X( X* O, J1 f
Summary | Full Text | PDF (345 kb)
6 p" D" u* I, {7 o0 a( ?The Ins and Outs of EGFR Asymmetry p513- u1 z5 s* X# o( v1 Y
Daniel J. Leahy
: ]' P1 H- {) D; [- R# q+ u# T9 \Summary | Full Text | PDF (324 kb)
  D8 L5 B) r, c2 ?: c1 n7 `1 R4 ^Up a Hydrophobic Creek with a Short Paddle p515* _7 `. Q' _( r2 Y  Z$ [
Raymond E. Hulse, Qufei Li, Eduardo Perozo. V/ s. w& Z/ b- b5 \; S$ o+ _
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The Immunoproteasome Cleans up after Inflammation p517# F& F, L  f( n! c
Sjoerd van Deventer, Jacques Neefjes
/ v# j. D  \2 ^+ U2 Z7 bSummary | Full Text | PDF (205 kb)
, o1 ]( Z# h! G+ mReview% c2 @9 T! t* M( J2 I( \3 S
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Featured Article
5 r2 ~. O8 a0 OCellular Strategies for Regulating DNA Supercoiling: A Single-Molecule Perspective p519
$ h- x, h& ^5 NDaniel A. Koster, Aurélien Crut, Stewart Shuman, Mary-Ann Bjornsti, Nynke H. Dekker
8 |8 L1 j" D' E2 pSummary | Full Text | PDF (1484 kb) | Supplemental Data! I% H- x& U9 i
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Reversal of Cancer Cachexia and Muscle Wasting by ActRIIB Antagonism Leads to Prolonged Survival p5318 d* U7 y5 e& C
Xiaolan Zhou, Jin Lin Wang, John Lu, Yanping Song, Keith S. Kwak, Qingsheng Jiao, Robert Rosenfeld, Qing Chen, Thomas Boone, W. Scott Simonet, David L. Lacey, Alfred L. Goldberg, H.Q. Han
2 F/ Y2 ^6 s6 F9 z; M/ cSummary | Full Text* [( y+ W$ q. A, |" E5 A% n
PcrA Helicase Dismantles RecA Filaments by Reeling in DNA in Uniform Steps p5441 a1 ~3 h# `! B* ^7 C5 H8 V1 `
Jeehae Park, Sua Myong, Anita Niedziela-Majka, Kyung Suk Lee, Jin Yu, Timothy M. Lohman, Taekjip Ha
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The Monopolin Complex Crosslinks Kinetochore Components to Regulate Chromosome-Microtubule Attachments p556
: ~: d/ z9 O8 S+ r' ~. e' c! }Kevin D. Corbett, Calvin K. Yip, Ly-Sha Ee, Thomas Walz, Angelika Amon, Stephen C. Harrison" X5 H$ X6 q' i
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Structural Basis for Negative Cooperativity in Growth Factor Binding to an EGF Receptor p5682 e8 T9 e! j% i# z" @
Diego Alvarado, Daryl E. Klein, Mark A. Lemmon
  c3 b6 L( F& X* h+ {Summary | Full Text- O; z' @" T. e9 I
A Shaker K+ Channel with a Miniature Engineered Voltage Sensor p580
7 f, [1 x/ t1 X9 g! v$ ^& cYanping Xu, Yajamana Ramu, Zhe Lu
# }* U# A5 ?: JSummary | Full Text# _6 q# x$ D4 d3 W6 U# m
ATG12 Conjugation to ATG3 Regulates Mitochondrial Homeostasis and Cell Death p5902 k# `3 \: X4 V
Lilliana Radoshevich, Lyndsay Murrow, Nan Chen, Estefania Fernandez, Srirupa Roy, Christopher Fung, Jayanta Debnath
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Identification of MOAG-4/SERF as a Regulator of Age-Related Proteotoxicity p6012 Y8 {9 y6 M" j# Y
Tjakko J. van Ham, Mats A. Holmberg, Annemieke T. van der Goot, Eva Teuling, Moises Garcia-Arencibia, Hyun-eui Kim, Deguo Du, Karen L. Thijssen, Marit Wiersma, Rogier Burggraaff, Petra van Bergeijk, Jeroen van Rheenen, G. Jerre van Veluw, Robert M.W. Hofstra, David C. Rubinsztein, Ellen A.A. Nollen
# U0 F% G& M$ ?+ `# p2 }Summary | Full Text2 s! _6 z4 ~; b) s. F
Immunoproteasomes Preserve Protein Homeostasis upon Interferon-Induced Oxidative Stress p613
- W+ n/ T2 Y8 a, d5 EUlrike Seifert, Lukasz P. Bialy, Frédéric Ebstein, Dawadschargal Bech-Otschir, Antje Voigt, Friederike Schröter, Timour Prozorovski, Nicole Lange, Janos Steffen, Melanie Rieger, Ulrike Kuckelkorn, Orhan Aktas, Peter-M. Kloetzel, Elke Krüger
, ?/ ~* b! O4 d# ~. R6 mSummary | Full Text
2 Q# f, B+ ^! w" k% y* aAn Alternative Splicing Network Links Cell-Cycle Control to Apoptosis p6259 c3 K. N1 b3 A2 Z: y* }# L
Michael J. Moore, Qingqing Wang, Caleb J. Kennedy, Pamela A. Silver5 f+ N" d$ D$ m2 U. F, q: f/ o
Summary | Full Text
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9 Q& c5 T, z+ Q& z  f% SFeatured Article
7 {. H/ V3 s0 o4 [) i$ SActivation of Specific Apoptotic Caspases with an Engineered Small-Molecule-Activated Protease p637& ~8 W/ o+ h0 C! J) {: H& h
Daniel C. Gray, Sami Mahrus, James A. Wells
! U0 \9 ~, U* `- p) d' j( rSummary | Full Text. c% v  G! ^: L7 z
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SnapShot: Homologous Recombination in DNA Double-Strand Break Repair p648.e1
2 |' K4 @8 P, w0 G# X1 h+ ~Gerard Mazón, Eleni P. Mimitou, Lorraine S. Symington
9 N& O* @6 r# J; e1 ^0 I9 A! kPDF (1491 kb)2 k1 P9 a% P. w* Q) a. v9 O/ T. i
想看赶紧下哦，呵呵
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张也行

哈哈 谢谢分享

baixueyao029

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军医

谢谢啊

aehxing

回复 1# scienese

mckf111

太谢谢

initiation

谢谢！

懵懂干细胞

谢谢分享

豆腐干

好好学习，天天向上

susannajoke

谢谢！