Possible ways can be used to eradicate CSCs

aceman

Currently ,the research about cancer stem cells (CSCs) is a hot spot , while most of which is still in infancy , which means there still remains much needed to be elucidated .anyway , as the development of related research ,during the past decades , some progressed had been made in this new appearing field . now ,most researchers believe , CSCs is the root of tumor recurrence or relapse clinically , not only they are resistant to conventional chemotherapy or radiation ,but also other properties , which can render them to escape the immune attack in the body or the inhibitory effect of anti-cancer drug , therefore , it is urgent to find some way to specifically kill these CSCs in order to completely conquer the cancer . here ,after seeing related literatures ,I propose the following methods which can be used to deplete the CSCs , however ,there is no doubt as the research goes , many new findings would come out ,accordingly , the methods of eliminating CSCS would become more diverse .
4 Q- a% w* c# b9 l- Y/ mThe possible methods to eradicate the CSCs
8 Q3 f, \# `7 {, [7 Q1.        targeting the special signal transduction involved in CSCs ) k4 _+ f1 x, E$ c' y, E: N% Q7 i% K
such as Wnt/β-catenin, sonic Hedgehog, Notch , Bmi-1 ,Hox family ,and so on
% W8 O- n; f9 r, V7 W2.        making use of survival advantage of CSCs 8 K7 U7 J5 y, s8 u- u
such as the ATP-binding cassette of CSCs due to their high expression
4 [0 E, F( y8 h3 \( @4 w) M6 S3.        targeting the niche of CSCs ' A: h/ k+ s4 g+ r8 j: H
because CSCs reside in a relative hypoxic environment , the VEGF expression of which would be enhanced , there more some TKI (danatinib) or anti-VEGF antibody (Avastin) , moreover ,the surface Marker of CSCs can also be utilized ,such as CD44 ,CD133 ,ALDH ,nestin and so on . for example ,we can also design anti-CD44 antibody to target the CSCs specifically .) h8 l. A. d) F7 ~
4.        inducing the CSCs to differentiation . t) H& [/ c7 r
the application of ATRA to induce the differentiation of APL is a classical example + \" @, ~' x8 z0 r5 H8 _$ T
5.        high-through screening from the compound library to select the candidate compounds possessing potential activity against CSCs
8 [2 |7 ~  x; |- s) lThe finding of salinomycin to specifically eradicate breast cancer stem cell is a better evidence .+ `6 q# q. H) M+ v. ~6 w# C
Finally , owing to my limited ability and knowledge , there would veritably exist some mistakes or negligence in my discussion ,therefore , I sincerely invite members in this forum to join my discussion , and I also believe , the more we communicate , the more we will learn !

wlandragon

I am also be intereste in this topic good suggestions

mhm

xiexie

amywang

maybe it's not a single aspect working in CSCs
1 \2 q2 _) A2 z0 v. J: g3 e9 O
) Y/ ]% J+ b2 O' r! p% S0 Mtough job