Possible ways can be used to eradicate CSCs

aceman

Currently ,the research about cancer stem cells (CSCs) is a hot spot , while most of which is still in infancy , which means there still remains much needed to be elucidated .anyway , as the development of related research ,during the past decades , some progressed had been made in this new appearing field . now ,most researchers believe , CSCs is the root of tumor recurrence or relapse clinically , not only they are resistant to conventional chemotherapy or radiation ,but also other properties , which can render them to escape the immune attack in the body or the inhibitory effect of anti-cancer drug , therefore , it is urgent to find some way to specifically kill these CSCs in order to completely conquer the cancer . here ,after seeing related literatures ,I propose the following methods which can be used to deplete the CSCs , however ,there is no doubt as the research goes , many new findings would come out ,accordingly , the methods of eliminating CSCS would become more diverse .
% D2 M" t9 @( U! X- QThe possible methods to eradicate the CSCs
6 K( }% y6 ~" i7 o+ u1.        targeting the special signal transduction involved in CSCs 2 g5 t: Y8 x1 Z# F
such as Wnt/β-catenin, sonic Hedgehog, Notch , Bmi-1 ,Hox family ,and so on
$ Y4 U) Z, S) {2.        making use of survival advantage of CSCs
0 b3 f- ~$ E2 x; T! b- x! E5 x8 t; Hsuch as the ATP-binding cassette of CSCs due to their high expression # f( k) P# Z# u* T! s2 y
3.        targeting the niche of CSCs 8 x# a" |2 |, K3 O7 i5 \
because CSCs reside in a relative hypoxic environment , the VEGF expression of which would be enhanced , there more some TKI (danatinib) or anti-VEGF antibody (Avastin) , moreover ,the surface Marker of CSCs can also be utilized ,such as CD44 ,CD133 ,ALDH ,nestin and so on . for example ,we can also design anti-CD44 antibody to target the CSCs specifically .
* g+ e& f! E5 F0 O2 T4.        inducing the CSCs to differentiation : M* R5 I; O  A2 i$ N) g+ \' c
the application of ATRA to induce the differentiation of APL is a classical example
6 }. {0 p! Z% w" Z- |5.        high-through screening from the compound library to select the candidate compounds possessing potential activity against CSCs " `$ }7 t- L- L
The finding of salinomycin to specifically eradicate breast cancer stem cell is a better evidence .- F/ O% |$ {0 C" ?0 _; k
Finally , owing to my limited ability and knowledge , there would veritably exist some mistakes or negligence in my discussion ,therefore , I sincerely invite members in this forum to join my discussion , and I also believe , the more we communicate , the more we will learn !

wlandragon

I am also be intereste in this topic good suggestions

mhm

xiexie

amywang

maybe it's not a single aspect working in CSCs3 |* w/ P5 a" h/ `- A
8 G/ j& Z7 m0 e# ?
tough job