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本帖最后由 细胞海洋 于 2011-2-9 08:15 编辑 6 J% o* _3 C# }# p4 Z$ A. P2 W
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最近浏览期刊，发现2008年Cell杂志有一期干细胞研究的综述，内容非常全面，感觉对大家非常有用，可以作为教材来研究学习。下载时把文章的补充材料也下下来，供大家学习。1 Y9 a+ c9 d7 ?8 W7 D! ^
Stem cells have two remarkable abilities: they can self-renew to keep the stem cell pool replenished, and* ?: b- z" ?# M$ u5 x! P, B* f6 m
they can differentiate into a wide variety of cell types. This stunning biological duality intrigues not only
) N B2 r K. y2 M8 j x9 j) n' ~those interested in the basic mechanisms of development, differentiation, and reprogramming, but8 O5 J7 n& h3 A
also those who seek to use stem cells therapeutically to replace lost or damaged tissue. But when did
- }: N: W; q- K1 C; V3 uthe stem cell revolution start? It was back in the 1960s that two Canadian researchers, Ernest A. McCulloch' v: P4 v+ F4 E0 P- {: _! U
and James E. Till, launched the field of stem cell research with their groundbreaking work on the hematopoietic! p, t' c5 u- R. r
stem cells of mouse bone marrow. By designing clonogenic assays to measure stem cell differentiation
. \ p4 R' ~' P m9 \ q' ^$ h7 `in vitro and serial transplantation assays to study stem cell repopulating ability in vivo, Till and: s3 d- a( @7 y( D. [* @& V9 M
McCulloch defined the hallmark characteristics of stem cells.( W/ V+ R1 H% O4 k
The field of stem cell research has come a long way in 50 years, as we hope will be apparent from this! h! l! h! x6 D/ _
year’s Special Review Issue. Our goal in this issue is to highlight the remarkable biological features of
; i' d1 u( K/ cstem cells, the molecular pathways that control these characteristics, and the ways in which these enigmatic
$ ~/ J: i( G9 R4 x# ]cells can be exploited for cell replacement therapy. We would like to thank the many distinguished) \1 _% u% W& `$ ?: R! s
experts who contributed their time and efforts as authors and reviewers to make this special issue on
' U; }/ l! g! U. _stem cells informative, thought-provoking, and timely. We hope that this collection of articles conveys
1 A/ J) A: ~: ~4 R- ithe excitement and promise of stem cell research, as we enter a new era of possibility. |
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发表于 2011-2-8 23:40
发表于 2011-2-9 09:33
