2008年Cell杂志的一期不错的干细胞特刊

yusheen

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* ~$ D8 ]8 _2 F: F- Y2 |0 j最近浏览期刊，发现2008年Cell杂志有一期干细胞研究的综述，内容非常全面，感觉对大家非常有用，可以作为教材来研究学习。下载时把文章的补充材料也下下来，供大家学习。% {' u% e/ H) ~- s' h: p
Stem cells have two remarkable abilities: they can self-renew to keep the stem cell pool replenished, and
9 v+ n- t! @9 kthey can differentiate into a wide variety of cell types. This stunning biological duality intrigues not only5 j& g/ a5 U1 h
those interested in the basic mechanisms of development, differentiation, and reprogramming, but- V& M' l) G& ]- {: I' [
also those who seek to use stem cells therapeutically to replace lost or damaged tissue. But when did% Z% f% I" I" }4 W4 S4 `
the stem cell revolution start? It was back in the 1960s that two Canadian researchers, Ernest A. McCulloch- ^$ k, I& j7 D3 A8 H% c2 n6 d# m
and James E. Till, launched the field of stem cell research with their groundbreaking work on the hematopoietic" J2 T9 Y) V4 M% v
stem cells of mouse bone marrow. By designing clonogenic assays to measure stem cell differentiation
4 s9 n3 {1 _% [* x2 n; Win vitro and serial transplantation assays to study stem cell repopulating ability in vivo, Till and
" O$ w' a- x1 v% V# v) e1 g2 eMcCulloch defined the hallmark characteristics of stem cells.; H/ C9 Z& F# X3 |6 c
The field of stem cell research has come a long way in 50 years, as we hope will be apparent from this
$ W& e$ C, u& ^; |year’s Special Review Issue. Our goal in this issue is to highlight the remarkable biological features of" W0 ~5 W* u# ?! t7 N$ |) o
stem cells, the molecular pathways that control these characteristics, and the ways in which these enigmatic
$ j* D3 @! [; Dcells can be exploited for cell replacement therapy. We would like to thank the many distinguished
3 g/ t' b- H  y3 f1 |# }% w0 lexperts who contributed their time and efforts as authors and reviewers to make this special issue on& V3 o1 N6 |! _: d# G. g5 T9 [
stem cells informative, thought-provoking, and timely. We hope that this collection of articles conveys3 o# j5 P0 c0 }" x
the excitement and promise of stem cell research, as we enter a new era of possibility.

dglove

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