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2010年Science杂志总结出的10大科技进展中，有关细胞重编程的描述：
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Souped-Up Cellular Reprogramming
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Changing a cell’s fate by adding extra copies of a few genes has become routine in labs around the world. The technique,# e# a2 C/ \! A7 L3 o1 ^# j# J
known as cellular reprogramming, allows scientists to turn back a cell’s developmental clock, making adult cells behave7 U5 m. m& i7 d3 C
like embryonic stem cells (see “Insights of the Decade,” p. 1612). The resulting induced pluripotent stem cells (iPSCs)7 u, l* g4 m6 |1 w, ^
are helping scientists to study a variety of diseases and may someday help to treat patients by supplying them with genetically' e, H1 l/ d5 o& q$ J. n* L. i
matched replacement cells.
. y% J# c1 O1 y8 A* T0 x9 ^This year, scientists found a way to make reprogramming even easier using synthetic RNA molecules. The synthetic RNAs
- a, T. {" i! j& n9 X* V, `are designed to elude the cell’s antiviral defenses, which usually attack foreign RNA. The technique is twice as fast and 100 times1 T# P* j, j2 u& e1 K W
as efficient as standard techniques. And because the RNA quickly breaks down, the reprogrammed cells are genetically identical
# `+ y" {& H9 q5 Sto the source cells, making them potentially safer for use in therapies.
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% M9 z4 L# z4 S3 OEarly evidence suggests that the RNA approach reprograms the cell more thoroughly than other methods do, yielding a
, q9 u# d, }) I, j. Ncloser match to embryonic stem cells. The method can also prompt cells to become nonembryonic cell types. By inserting synthetic
+ L$ r/ K, V' i3 dRNA into a cell that codes for a key gene in muscle tissue, for example, the researchers could turn both fi broblasts and iPSCs into muscle cells.% J. a8 u N0 D% n# _& E
编者对具有调控的RNA分子在细胞重编程中的作用的预言，这么快就实现了，呵呵，说不定就是文章的作者提前透露出来的消息呢。
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发表于 2011-4-8 09:25
发表于 2011-4-8 21:20
