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Kyle M. Loh, and Bing Lim0 ]3 r2 x0 @3 C/ b& x) ?
Understanding the basis of the unrestricted multilineage differentiation potential of pluripotent cells will be of
7 s+ {# j3 l& o" i0 Cdevelopmental and translational consequence. We propose that pluripotency transcription factors are
& V% g( w2 N y5 g/ C4 {lineage specifiers that direct commitment to specific fetal lineages. Individual factors bestow the ability to
1 U& x6 y S* y+ K- W# @differentiate into particular cell types, and concomitant expression of multiple lineage specifiers within pluripotent- J/ m. j( l' r0 Q u d9 d2 [
cells enables differentiation into every fetal lineage. Moreover, we speculate that, rather than being an- C" X9 |+ y) S. _. f% r
intrinsically stable ‘‘ground state,’’ pluripotency is an inherently precarious condition in which rival lineage
9 X+ q4 U- ~; v& L' nspecifiers continually compete to specify differentiation along mutually exclusive lineages.
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发表于 2011-5-5 11:41
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