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Cells can communicate with each other through the: z4 E) }' R' m+ ]+ t' B
secretion of cytokines, small (8–30 kDa) soluble proteins.7 C$ Y4 Y. R. y+ c9 ^! k" r& |
To date, roughly 20 cytokines have been identified. Upon
. F' i8 K4 y* hbinding their cognate receptors, receptor-associated Janus$ K1 I' Y( \; ~7 d: C# }* \
Kinases (JAKS) phosphorylate tyrosine residues of the
+ B) v* b" J# `ligand-bound receptors, as well as interacting Signal& }/ v" ?; W1 b2 L- j: l/ n( P) c+ g
Transducers and Activators of Transcription (STATs).Tyrosine phosphorylated STATs form homodimers, shuttle+ G; M: P+ \+ s: g" J) H
to the nucleus and participate in transcriptional regulation
x& k% C7 l8 \. \6 A# w D/ Cof a variety of genes
# F4 j; W/ {/ X' x0 [1 A% o
! `, I* \' k& r, I, w我标记的这一句,是什么意思呢 ,为什么我连语法结构都分析不过来呢,总感觉少了点什么!希望热心人给予解答! |
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