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Emerging models and paradigms for stem cell ageing
+ z9 K7 K1 d( GD. Leanne Jones and Thomas A. Rando
G+ A( n! W" ^5 O" q+ b% o! a1 qAgeing is accompanied by a progressive decline in stem cell function, resulting in less effective tissue homeostasis and repair.7 h2 s0 N! f, U: Q6 v: y8 [* F$ z
Here we discuss emerging invertebrate models that provide insights into molecular pathways of age-related stem cell dysfunction$ W' t5 H/ j0 H- ]
in mammals, and we present various paradigms of how stem cell functionality changes with age, including impaired self-renewal
: `4 u3 i. k$ Zand aberrant differentiation potential. B! w7 M8 K, P1 j
"Nature cell biology 13(5) 2011"
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发表于 2011-7-11 10:26
