再来一本病毒学经典--Virology:principles and applications--John B. Carter

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[hide][/hide]$ @2 D! M6 }! q$ ^; B( P- L
Virology - Principles and Applications) \" a8 A6 F* o
Dr John Carter (Liverpool John Moores University, UK), Prof Venetia Saunders (Liverpool John Moores University, UK)! Q6 Y: \& T2 _% H3 S
August 2007, ©2007
9 f& ~7 X; y8 S' Oby Dr John Carter, Prof Venetia Saunders1 _# K# T) w9 {* ~2 \4 d
ISBN 978-0-470-02387-7) r  p7 R) |* _
Preface.
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Abbreviations used in this book.2 m7 b# G# q1 g
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Greek letters used in this book.
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Colour coding for molecules.
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% `8 B4 A+ G: ^- t' |1 Viruses and their importance.
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1.1 Viruses are ubiquitous on Earth.) v* J  q8 a; a& L: h1 p

9 M8 |, }6 ?  G* p/ s1.2 Reasons for studying viruses.  M5 ?$ B3 C7 R3 Y% P0 V

. m2 W, a8 K6 K$ k  }5 x) `1.3 The nature of viruses.
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1 R& B" e$ O) {0 W1.4 The remainder of the book.1 f3 J7 Y. X: N7 M5 @( s

. h6 |+ V- S. S$ o0 P/ f# M2 Methods used in virology.: A' j9 g+ E. q% J+ w1 J

: W" M$ {8 L% Z, P2 p& v2.1 Introduction to methods used in virology.
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2.2 Cultivation of viruses.
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2 D$ [1 x/ H  G2.3 Isolation of viruses.
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2.4 Centrifugation.
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2.5 Structural investigations of cells and virions.* }" A5 q1 i& ^- `/ W# R6 X' N
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2.6 Electrophoretic techniques.7 j8 g! m: \3 E; G/ R) I
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2.7 Detection of viruses and virus components.
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! U5 V9 {) h% u! g1 c2.8 Infectivity assays.+ M3 i& P! p* L& Y

7 G& X5 ^4 t& P- b, s6 e2.9 Virus genetics.$ R% T2 z" F9 h. t$ G0 r. O
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3 Virus structure.
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3.1 Introduction to virus structure.
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3.2 Virus genomes.7 k- d% V5 q6 ]* v1 B& u

( S. ^5 M5 J4 ^7 g7 t( c7 }: V3.3 Virus proteins.
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3.4 Capsids.* t5 X9 X* [/ m9 t2 c% P1 a
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3.5 Virion membranes.
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. k5 C0 Q: R( t( }3 |1 @3.6 Occlusion bodies.
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3.7 Other virion components.
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4 Virus transmission.
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4.1 Introduction to virus transmission.3 O, U- [) ?4 _' A) c( M
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4.2 Transmission of plant viruses.
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9 j7 M2 L& W! k& f: z% b8 c4.3 Transmission of vertebrate viruses.8 z. f3 n  `0 V1 Z: n- O
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4.4 Transmission of invertebrate viruses.2 ?0 H4 X- a0 h; c% T1 K
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4.5 Permissive cells." Z* B; W" ~) O6 D5 u- ~; {4 Y: D$ [. ?

: v) r3 Y7 k+ I4 G% U" Z2 v: Q7 b  g5 Attachment and entry of viruses into cells." i- M: z! p1 h, }

4 g- y; B# M# ^  [+ Z5.1 Overview of virus replication.
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5.2 Animal viruses.
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5.3 Bacteriophages.! \) R/ _% K& H* Z: Q  g. W
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6 Transcription, translation and transport.
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' e3 _2 j' A! v0 s6.1 Introduction to transcription, translation and transport.# D+ G( t) E2 i$ W

1 d0 R' [" M3 c* @; ~2 r6.2 Transcription of virus genomes.+ N& c" \5 ]0 [  }

# h% o% Q4 D) o/ o5 A' ~) D6.3 Transcription in eukaryotes.4 u; X* ~5 i% k" y0 o0 c

! h1 ^* Z; v4 s. `7 l  b4 x6.4 Translation in eukaryotes.
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6.5 Transport in eukaryotic cells.
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/ h' }4 }/ g7 b6.6 Transcription and translation in bacteria., P- H" G3 L9 b0 q2 M8 T9 X
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7 Virus genome replication.
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7.1 Overview of virus genome replication.# {1 I! T: p, T4 y4 t! f- ^
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7.2 Locations of virus genome replication in eukaryotic cells.) l# o" [: k0 d2 N2 N( Y3 R# q
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7.3 Initiation of genome replication.
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7.4 Polymerases.% Y. i8 N4 B4 }: Y' G: ~

, d# _2 Z5 X) ?4 o; C# r. @9 P7.5 DNA replication.0 a2 W+ \# x% |/ a! X/ p& i
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7.6 Double-stranded RNA replication.
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7.7 Single-stranded RNA replication.
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+ A( O$ A, k% x7.8 Reverse transcription.4 Z* f, N/ o6 ^& u# n1 g
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8 Assembly and exit of virions from cells.7 K8 p* b7 ]3 Y

. v9 S+ v$ Y8 r9 h4 [1 s8.1 Introduction to assembly and exit of virions from cells.  `8 v: `  W! p6 T$ |. _9 @
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8.2 Nucleocapsid assembly.
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' H: v* g5 o, s* ~$ ^* J* z8.3 Formation of virion membranes.
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8.4 Virion exit from the infected cell.! ]- U7 Q' X, Q5 O6 W" i
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9 Outcomes of infection for the host.
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$ p/ o. l4 U' y" ^9.1 Introduction to outcomes of infection for the host.
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% g( G9 ?0 ^* I  c6 ^" x9.2 Factors affecting outcomes of infection.3 j, [4 Z1 K7 B; _8 U7 C% S# x2 z
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9.3 Non-productive infections.
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7 S8 c( R: U* f/ b0 ]1 n- t9.4 Productive infections.$ P0 U$ ]6 f, z* U1 Z

& z& @4 m: E0 e! z) M10 Classification and nomenclature of viruses.
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10.1 History of virus classification and nomenclature.! B9 ~. z& f( c  N

% D. m; M% p( E+ v10.2 Modern virus classification and nomenclature.
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# [8 P( J* c' z" o% E10.3 Baltimore classification of viruses.% T# e$ T! y: N. R; F8 r& P2 u
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11 Herpesviruses (and other dsDNA viruses).% P2 q1 v. ^7 t* P; i) q( e1 z

' {8 C0 z; C" S+ A/ r0 F' J11.1 Introduction to herpesviruses.
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11.2 The human herpesviruses.
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11.3 The herpesvirus virion.: C% }4 i( B. o7 d4 E: I' p5 X, J
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11.4 HSV-1 genome organization.
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9 Z. K+ a7 M, L0 z) g: i, C11.5 HSV-1 replication.
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11.6 Latent herpesvirus infection.& O* A. I" u( D: E& G6 J7 \
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11.7 Other dsDNA viruses.
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  b+ X2 m: _/ A/ K: H* I. m12 Parvoviruses (and other ssDNA viruses).
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12.1 Introduction to parvoviruses.
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12.2 Examples of parvoviruses.
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1 w2 k% W3 X7 P12.3 Parvovirus virion.! n5 O8 `8 y/ i( G& b

, `# Y. z% |6 @12.4 Parvovirus replication.1 ]- D& |. c& y0 \/ t% Y& r

0 v0 W1 D% l6 M; _5 C* Z4 o4 K12.5 Other ssDNA viruses.) m) w( E( ?' t1 U9 w4 c6 l
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13 Reoviruses (and other dsRNA viruses).
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13.1 Introduction to reoviruses.0 g; f# M9 u' D# e5 f& v3 l

( ]: p  M/ l" h5 H7 [- j13.2 Rotavirus virion.& F2 t2 a5 |* s
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13.3 Rotavirus replication.
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0 \. `3 ~  v$ C& n2 {. Q13.4 Other dsRNA viruses.5 s" `% [2 d8 M& u
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14 Picornaviruses (and other plus-strand RNA viruses).
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7 c1 Z. M1 u# e+ v14.1 Introduction to picornaviruses.% o. s, p4 s" ~( u/ R* }

% ^3 Z8 L* \) |/ k& S14.2 Some important picornaviruses.
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14.3 The picornavirus virion.
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14.4 Picornavirus replication.
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14.5 Picornavirus recombination.6 y+ o. _; u' m% g' g3 I4 |! _" G

7 r# k& |# Y: f% [7 X. h; V4 y4 A14.6 Picornavirus experimental systems
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14.7 Other plus-strand RNA viruses., r+ c$ H& J- Z( z

8 S3 S" V% j: P! M1 W8 n15 Rhabdoviruses (and other minus-strand RNA viruses).' O) g* A- e( V
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15.1 Introduction to rhabdoviruses.; `( t  a* l" U9 G3 l

' x; }0 M) R' b. R: h' }, R15.2 Some important rhabdoviruses.% a( Q9 v, D! M) [
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15.3 The rhabdovirus virion and genome organization.+ f9 Y' t% S7 v& M# I
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15.4 Rhabdovirus replication.7 C" O) ^, N: ^( I

" I3 Y8 d4 B7 M9 H' T# N! ^: T15.5 Other minus-strand RNA viruses.! h# G. g* K; @: G- S

- A/ ]0 w- z  l. w8 I% u15.6 Viruses with ambisense genomes.
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, u+ x# U. u( Q: J0 a15.7 Reverse genetics.$ |2 g  n* O  P4 L, S
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16 Retroviruses.( v4 h8 s! K; ~: G8 y0 `" n
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16.1 Introduction to retroviruses./ k, K; I9 G+ Q  K( `

3 {. }* k4 I4 a  T/ K" c16.2 Retrovirus virion.
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( V! ?8 L% h% Z0 G- q! d. i  v6 }16.3 Retrovirus replication.* u% ~3 c" a% G( v, y0 u

/ G9 s9 q  P6 ^* |16.4 Examples of retroviruses.! Z4 o. U4 t/ Q3 D/ Q  b: d

$ f6 d8 T/ G! }5 b5 n9 C; V16.5 Retroviruses as gene vectors.; ?; X9 b; Z" y% ^* B* s( l+ e
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16.6 Endogenous retroviruses.; f  d1 f6 r3 O1 w

/ S  {+ W3 G, b5 j% G: O2 Q17 Human immunodeficiency viruses.
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0 F! _2 v" H/ k4 }; @/ T- i0 t) h1 F17.1 Introduction to HIV.
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& K9 k) }' M& T6 N5 [17.2 HIV virion.
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8 c8 {/ V# y- ^# O- i0 u, `8 t) d  e17.3 HIV genome.; w4 e1 N4 g1 a( h4 e0 D; ^$ w- a

0 c5 Y4 z. D1 g4 N17.4 HIV-1 replication.3 k3 S" O  g8 R; O. B
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17.5 HIV-1 variability.6 m7 `1 A" ^/ t
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17.6 Progression of HIV infection.
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17.7 Prevention of HIV transmission.) y+ X: T# Y6 N! Q
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18 Hepadnaviruses (and other reverse-transcribing DNA viruses).
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' p* h6 \7 t3 b# j$ H18.1 Introduction to hepadnaviruses.
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18.2 Importance of HBV.
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9 P. w) W, R2 ?; k, n18.3 HBV virion.* S( X  {4 I' d4 ~0 T
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18.4 Non-infectious particles.
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) P) p( S/ E5 l3 \" x18.5 Soluble virus protein.6 C: g/ n- c9 o! o6 s9 u9 O) q* F
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18.6 HBV genome.
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18.7 HBV genetic groups.
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18.8 HBV replication cycle.# G6 Q" c$ a& }0 ]$ F2 Q

/ e4 M  I9 O- I" s18.9 Prevention and treatment of HBV infection.
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7 M8 G2 J' U/ h18.10 Other reverse-transcribing DNA viruses.
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) C3 t8 \  r$ o* b19 Bacterial viruses.6 Z: D# S$ I+ M4 f
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19.1 Introduction to bacterial viruses (bacteriophages.; S2 A; Z. t- f2 E) `
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RNA PHAGES.
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: C2 z% z2 I1 R' ~19.2 Single-stranded RNA phages.
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19.3 Double-stranded RNA phages.& P+ E6 j- j  ?' m, e( d; l% V
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DNA PHAGES.* Z. P/ J( _& [; I

7 S  \# P& I" G8 b19.4 Single-stranded DNA phages.3 C0 Q$ z2 g3 `* J$ `2 X

# `# R2 O3 h9 o6 _# N$ C6 B& V19.5 Double-stranded DNA phages.( a# t" n5 K2 ?+ \7 e$ O* t" _
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20 Origins and evolution of viruses.
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( \* T, z4 R* n8 V( }. \8 U21.1 Introduction to origins and evolution of viruses.. l  }% w3 g7 i7 G  j' i. C/ R

% Y+ A- x& c* b5 ]" k' [: e20.2 Origins of viruses.
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20.3 Evolution of viruses.
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, W7 S5 P/ i" z2 R8 _/ o7 Y21 Emerging viruses.
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21.1 Introduction to emerging viruses
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21.2 Viruses in new host species7 @& ?0 I2 ]; N' l. G& e* Y

4 ~, F6 R: u' O) U4 i5 L21.3 Viruses in new areas
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% h( y. y. b$ l# d7 t% e: W21.4 Viruses in new host species and in new areas4 s2 L0 q' R9 ?) m& o

, |$ H' I0 C! b# l# V/ h! ~21.5 New viruses4 B8 h% q5 K7 x( I0 B0 N+ O& \' e

, w7 m- `  D& O9 o5 w" h21.6 Recently discovered virus1 m0 e, Z6 Y2 C+ Z+ Z
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21.7 Re-emerging viruses1 U; v  P* N8 i6 p# F8 X, l
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21.8 Virus surveillance
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21.9 Dealing with outbreaks5 ~5 F/ v4 G4 V- ^, |

  B9 M+ i- C, M2 O/ Q5 Y- N22 Viruses and cancer
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22.1 Introduction to viruses and cancer" R- F: ?) S) o; q6 v) D

) v+ g  H" q2 a22.2 Papillomavirus-linked cancers
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- S* T4 c* m; h/ o# s22.3 Polyomavirus-linked cancers
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! O! \' @7 z) J% S22.4 Epstein-Barr virus-linked cancers, @! U, n$ n( J7 |$ z3 M
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22.5 Kaposi’s sarcoma
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3 {5 x9 R* ]5 ?" j$ i2 |4 Y8 k22.6 Adult T cell leukaemia( Y) E8 y) r( K* p% U. j! R

3 O- g+ m$ u, w# Q5 J3 l5 |22.7 Hepatocellular carcinoma
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22.8 Virus-associated cancers in animals- M, b2 a5 i+ A/ @

: B# G+ Y% Z$ z' z7 j1 H% M22.9 Cell lines derived from virus-associated cancers.
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: [; @& [! U# v8 D+ v5 R22.10 How do viruses cause cancer?
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/ d7 K  O: x# A* @9 R9 `% ?22.11 Prevention of virus-induced cancers.
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) r: I. y! h# [6 H' e9 Z23 Survival of infectivity.
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! f( D4 q: l9 p; N) a; ^, E23.1 Preservation of virus infectivity.0 s# C5 C* z1 \: A0 U
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23.2 Destruction of virus infectivity.
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9 n) x5 w  a2 w9 ]2 n6 r/ Z23.3 Inactivation targets in virions.% \! E5 V. V" O( _& K8 {( g

8 S; a, q% Z9 M; O. F$ I9 N23.4 Inactivation kinetics.
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+ M) W2 P8 O) \23.5 Agents that inactivate virus infectivity.2 q2 g2 n3 K4 P( z3 e; i$ S
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24 Virus vaccines.) m# ~- F( L: s+ {

7 g% H4 k! P% x& D" u% F24.1 Introduction to virus vaccines.
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/ Z2 \4 q3 F0 d2 J24.2 Live attenuated virus vaccines.
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( z9 x* J3 @: \- x& Q$ c5 E24.3 Inactivated virus vaccines.
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4 S; O0 ?+ F+ Y+ C( i) R24.4 Virion subunit vaccines.
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! \+ h" ]) C& e+ i  N& r' c24.5 Live recombinant virus vaccines.) z& q# g4 [) l# e, @; ]9 h" E

* ^' r" i3 k/ l) S24.6 Mass production of viruses for vaccines.
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24.7 Virus-like particles.
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! }3 K6 b/ Z5 T$ {" W24.8 Synthetic peptide vaccines.
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' I, \$ G0 T0 }7 U: J+ F6 T24.9 DNA vaccines.
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& ^8 \2 v1 E9 Q) |  C" C9 e24.10 Storage and transport of vaccines.
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25 Anti-viral drugs.
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& K) `" P3 ], I) Q7 X25.1 Introduction to anti-viral drugs.
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# I/ l7 h; h) S' h6 I. Y1 n) i25.2 Development of anti-viral drugs.. X$ s5 W" G% ^" f# u0 j4 q

6 W9 n* s9 [' }25.3 Examples of anti-viral drugs.7 u0 h+ k7 f: ]( c- `1 g. w
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25.4 Drug resistance.. b8 y/ v) G' d) Z4 g+ D; J
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25.5 Anti-viral drug research.
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26 Prions.
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6 L( n+ @/ a7 x" u- P26.1 Introduction to prions.
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26.2 Transmissible spongiform encephalopathies.
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! q( u' B6 u2 X7 O26.3 The nature of prions.
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0 G5 _3 ~2 ^7 u; x+ P3 _! I8 O26.4 Prion diseases.
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3 A) |5 \- K: b, B% _+ N26.5 Prion strains.
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26.6 Prion transmission.7 l! [# h! \+ A+ Z8 f8 i1 D8 G
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26.7 The protein-only hypothesis., K- O6 C" F4 p* `% g. D0 q
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Learning outcomes., N% A: y) l1 U6 }" `
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Sources of further information.
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+ y9 {: l6 q, C0 PVirologists' vocabulary.
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2 X, l1 d# w/ r' ^3 |1 d' |  Y. z6 yIndex.

subenjinwo

好书！

yangpan521

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chleiwu

学习

tait1

kankan

zorro

3qqq

zzc2211

好书，谢谢楼主分享

白色的风

谢谢楼主

susannajoke

好东西

stem_cell007

kankan