再来一本病毒学经典--Virology:principles and applications--John B. Carter

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Virology - Principles and Applications; V( {! @4 P; w, E2 Q
Dr John Carter (Liverpool John Moores University, UK), Prof Venetia Saunders (Liverpool John Moores University, UK)' y' g" ]1 l/ ~; [) t
August 2007, ©2007
$ j6 \, H; f* Y( a4 B7 A$ Yby Dr John Carter, Prof Venetia Saunders
8 v* B% I9 s/ v9 b' R. bISBN 978-0-470-02387-7. ~9 ]- S5 H7 f: O& J
Preface.
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% |4 M3 C8 I8 B3 jAbbreviations used in this book.: j- y# X; R+ |- F
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Greek letters used in this book.
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8 u: l9 \; P, z4 P" k0 V; AColour coding for molecules.. G1 Y! q1 W) W4 @
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1 Viruses and their importance.- e  x: ^3 t, A, X$ W  M7 A) r
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1.1 Viruses are ubiquitous on Earth.
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1.2 Reasons for studying viruses.; {! k! B: C! ?1 z. ?
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1.3 The nature of viruses.
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5 M7 H+ T3 h( {1.4 The remainder of the book.
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& a8 n$ G" `% j7 G3 r/ c2 Methods used in virology.
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4 k( P* c: B/ i0 m# K! ]( s2.1 Introduction to methods used in virology.6 p' ?" J, C* H; n
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2.2 Cultivation of viruses.' v6 A: D* Z9 i6 r+ v7 ~
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2.3 Isolation of viruses.
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6 B3 X& x' m" j8 P2.4 Centrifugation.
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2.5 Structural investigations of cells and virions.
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: w5 W/ S. o/ o* A) O2.6 Electrophoretic techniques.
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# [, a- S6 c% \, `2.7 Detection of viruses and virus components.. j1 E+ c. z- J$ |) o2 G
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2.8 Infectivity assays.
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2.9 Virus genetics.
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3 Virus structure.3 q" i& \: A: o2 a

) r% @6 X# v5 g3 j3 ^7 _3.1 Introduction to virus structure.
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3.2 Virus genomes.
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3.3 Virus proteins.
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3.4 Capsids.
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0 @; T! `0 ?* s* ^! @. R3.5 Virion membranes.
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3.6 Occlusion bodies.' y( S' I6 x- O! p" o. n( B1 r
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3.7 Other virion components.; O* |+ k5 e& M% W9 @. }5 _

% W  t/ w% K# R4 Virus transmission.
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4.1 Introduction to virus transmission." }7 k4 _) t* N2 z2 ^4 I5 b% b8 {

- k& s, J: S6 u1 r# u# l) W9 Y4.2 Transmission of plant viruses.( ]- h2 j: D! I* p. C7 l/ ]

. p; {! m9 N* J* x4.3 Transmission of vertebrate viruses.
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4.4 Transmission of invertebrate viruses.
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4.5 Permissive cells.
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1 n& \. B: f, d' S% D7 s3 l# o5 Attachment and entry of viruses into cells.( e1 K) B' L  S. p6 S) j* U- ~
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5.1 Overview of virus replication.7 r/ W, \/ e9 q1 @0 A
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5.2 Animal viruses.7 Z6 y) R/ l1 c

1 Y4 H) B2 J4 W5.3 Bacteriophages.
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$ D& W' m, f5 r$ q6 Transcription, translation and transport.1 K8 Z; Q2 {! o

/ s! s- L( B; k+ H3 F: r6.1 Introduction to transcription, translation and transport.
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3 @1 l" f& N# F. z' g: g6 f6.2 Transcription of virus genomes.
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6.3 Transcription in eukaryotes.0 ^7 M4 A5 O: x( d; H% [; s7 \

, G3 {% j& t. A9 b* u6.4 Translation in eukaryotes.1 D5 V5 A$ K7 s, @- q/ o0 D8 a3 f

" E. a4 Y  b( `: |6.5 Transport in eukaryotic cells.
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! Z( G! a' S' [, P# G: P6.6 Transcription and translation in bacteria.
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5 ~0 s* A: S$ n* p7 Virus genome replication.( V. J9 q. B6 T2 h

1 s& k1 i6 a" R2 `0 H7.1 Overview of virus genome replication.2 Z' F7 y6 N5 G/ I# V" Y

; |5 n+ {0 b5 i3 V* ^" x5 k6 V& g/ G2 J7.2 Locations of virus genome replication in eukaryotic cells.  F, Z5 V$ B" _1 @

& |( W8 @+ O' O; o5 Q) K# w: j7.3 Initiation of genome replication.
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! j7 R+ H# g- S. J% Q7.4 Polymerases.
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7.5 DNA replication.
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6 u, }2 x) x! A* S; H6 c7.6 Double-stranded RNA replication.
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1 A. E; w+ A) j6 K7.7 Single-stranded RNA replication.
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0 c1 \, p+ Q' W8 l% `7.8 Reverse transcription.
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) T* i6 c5 `8 q" k* {8 E! F8 Assembly and exit of virions from cells.
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( r) |9 g2 A) I5 [  C6 D# p! }8.1 Introduction to assembly and exit of virions from cells.
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8.2 Nucleocapsid assembly.. K6 Q9 I& Y* _" F: E! Y+ w

$ L, R$ O, O, E2 |8.3 Formation of virion membranes.% f6 w/ B! O) S: S- q. G

0 x% ?# Z# A9 W* c. t  @+ W8.4 Virion exit from the infected cell.
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+ Y' W" q( V2 G- D- P9 Outcomes of infection for the host.
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9.1 Introduction to outcomes of infection for the host.) ^0 y! J7 f* x; ~

0 t. f1 u( {9 a" M8 e9.2 Factors affecting outcomes of infection.
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9.3 Non-productive infections.. ]7 f3 \# d3 R7 B! c
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9.4 Productive infections.5 n9 x8 G& l8 f+ h9 H

. ]9 U5 E- f, ^0 U" |# A5 F, m) S9 m! i10 Classification and nomenclature of viruses.
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10.1 History of virus classification and nomenclature.# g+ q; A% S) G0 ~' g, K
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10.2 Modern virus classification and nomenclature.
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4 T9 Q6 K6 S" {: Z5 P# C3 C10.3 Baltimore classification of viruses.0 e& h9 ?1 r1 _7 r- p

' v4 q( m( e5 _11 Herpesviruses (and other dsDNA viruses).
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! Q4 x8 E$ K; s( ~11.1 Introduction to herpesviruses.5 {9 J# P+ A2 u0 v$ J" h7 d

" Y- o. U* X* r; h+ b8 q11.2 The human herpesviruses.
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11.3 The herpesvirus virion.3 e$ H. o$ r$ O5 t, |% A+ l% `

: u# z% I* @: E$ B# D/ F11.4 HSV-1 genome organization.
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6 j8 s# E2 k; j6 ?3 g  y11.5 HSV-1 replication.
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11.6 Latent herpesvirus infection.
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11.7 Other dsDNA viruses." v, ?' T; O2 ]6 N( i
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12 Parvoviruses (and other ssDNA viruses).1 _7 F7 ^( t* d0 T% t) n9 O
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12.1 Introduction to parvoviruses.) F* ?5 A  J$ M" a
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12.2 Examples of parvoviruses.
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9 D! o  |% p  e& {+ u12.3 Parvovirus virion.4 Y/ y; l8 F* u& a

: q! u0 b, H: t12.4 Parvovirus replication.$ g% J; Z  x9 b6 b

3 {9 V7 _. H9 J" _6 u& d12.5 Other ssDNA viruses.' G; X$ k) J) S8 n

* N/ Q! Y' ~4 M+ }1 r2 e: @: S13 Reoviruses (and other dsRNA viruses).
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13.1 Introduction to reoviruses.
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13.2 Rotavirus virion.
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1 X& s* @2 N7 ~( E4 ?7 K1 q; Z13.3 Rotavirus replication.4 Y3 g. V; B- k

! T7 R7 q; n1 O13.4 Other dsRNA viruses.6 \( N/ k: t7 q
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14 Picornaviruses (and other plus-strand RNA viruses).: h5 Z) z* s' o8 w0 A3 H) w$ O2 E

/ X4 C4 |# V5 b14.1 Introduction to picornaviruses.; Q0 h! x9 R" ?* L: }( m: w5 O

" n+ m& ]& s8 Y* Z7 ?' V14.2 Some important picornaviruses.9 N( r) h$ E* n$ O) y
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14.3 The picornavirus virion.
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14.4 Picornavirus replication.$ i7 n! a3 K+ S
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14.5 Picornavirus recombination.
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: i% T% v9 O# I7 Y# J; x9 T+ Q14.6 Picornavirus experimental systems( B; A+ ?8 W4 j, u, t

; T' \  h/ j' K* \7 y7 a14.7 Other plus-strand RNA viruses.
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15 Rhabdoviruses (and other minus-strand RNA viruses).5 T7 z# A; I* a7 z8 h! K3 V( T7 Y6 ^

( e: w$ b- c$ K, P3 G3 f: x2 p15.1 Introduction to rhabdoviruses.
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- p+ C6 a6 w0 l6 `' y15.2 Some important rhabdoviruses.
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15.3 The rhabdovirus virion and genome organization.
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15.4 Rhabdovirus replication.
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* l0 M( h. W: D( w15.5 Other minus-strand RNA viruses.
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3 G! G( z+ i* P% U1 O15.6 Viruses with ambisense genomes.. I; X% M. l8 A! Q) O: P
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15.7 Reverse genetics.$ a% ^) t: h3 V& a; ~" m2 D
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16 Retroviruses.: ]5 H6 E; c6 W+ [  E

% e2 Z* x$ J6 ?9 N16.1 Introduction to retroviruses.
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16.2 Retrovirus virion.) p7 ~# f/ c& u: r) d/ n

0 U0 w0 {/ q3 f% n; s16.3 Retrovirus replication.
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' E) r' v1 _/ d  H: X16.4 Examples of retroviruses.
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16.5 Retroviruses as gene vectors.
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' g* a" E  \& L* s4 H16.6 Endogenous retroviruses.0 x& E0 s3 h# L$ a- O
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17 Human immunodeficiency viruses.
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17.1 Introduction to HIV.
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) ^: u. d0 C, F9 v! V$ s17.2 HIV virion.4 Z. }8 h) o. h
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17.3 HIV genome.
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17.4 HIV-1 replication.( O6 ?9 K" Y5 g

$ j' h4 m9 r' {8 m" l3 o; p; R3 L17.5 HIV-1 variability.
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17.6 Progression of HIV infection.
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% a- Y# V( L+ `& b* L% l17.7 Prevention of HIV transmission.
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" c, |7 B0 R  G( k" R18 Hepadnaviruses (and other reverse-transcribing DNA viruses).
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18.1 Introduction to hepadnaviruses.
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, N/ @+ e- c+ q18.2 Importance of HBV.
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: D5 F9 X, E1 o1 \3 a, ?5 `+ t0 i18.3 HBV virion.* @& M' J( h) D0 T1 H. V0 ]* [

& b  _' l* g- W2 ^5 x4 J5 x  ^18.4 Non-infectious particles.
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18.5 Soluble virus protein.9 s  L; l0 z8 U# k
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18.6 HBV genome.8 O/ [6 G% f6 Z  K
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18.7 HBV genetic groups./ N8 z" |8 i' ^# d% W
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18.8 HBV replication cycle./ X& q1 a& |% w

( z. P$ I- @9 c* t" u1 K" w1 f18.9 Prevention and treatment of HBV infection.* L/ r1 @8 a: L. P0 K
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18.10 Other reverse-transcribing DNA viruses.. A& N$ z4 l" F* y: J" K, Q+ C2 O8 A

  R  v/ Z/ I! }# M9 i+ _5 S19 Bacterial viruses.
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4 \9 o& s7 p9 J" ^7 o19.1 Introduction to bacterial viruses (bacteriophages.
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# q2 w) H1 D2 _0 U/ z+ Y3 j4 J( b" NRNA PHAGES.
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- p( n4 P' u% ], O7 s% Q$ L19.2 Single-stranded RNA phages.4 o- O3 x: H4 ~# z# f3 A+ b

9 x4 _0 J1 |# a  E6 E. X1 V19.3 Double-stranded RNA phages.
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( n2 Z$ f$ N2 d6 r" Y) IDNA PHAGES.3 J0 B. G( V- |( {) ^( l: E
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19.4 Single-stranded DNA phages.
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1 f: B% _( l) P19.5 Double-stranded DNA phages./ u1 I# ^5 A; P
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20 Origins and evolution of viruses.
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21.1 Introduction to origins and evolution of viruses.
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20.2 Origins of viruses.
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. S) @0 m  }" z- P: G: F; |20.3 Evolution of viruses.8 B5 o; D# k, u" [' t3 A3 H
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21 Emerging viruses.& _. z- H: Y! t  k7 ^

" _* c' M" m+ ?( r6 m+ ^0 f21.1 Introduction to emerging viruses9 v  R% f* L, h7 ]$ l. {
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21.2 Viruses in new host species7 h) ]' A- \$ ~! T
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21.3 Viruses in new areas: I3 K! o) b6 y# r0 x

5 h3 _5 s. _* r; u5 r, T/ u' Q( d21.4 Viruses in new host species and in new areas6 a+ d6 n& S4 N& Z9 Y2 k# w8 Q$ s

8 e0 @1 m& C4 g: C6 E- \  p21.5 New viruses
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21.6 Recently discovered virus
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21.7 Re-emerging viruses7 |4 p$ a9 i  w- S  @

0 x9 u1 E6 [$ t21.8 Virus surveillance
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21.9 Dealing with outbreaks
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22 Viruses and cancer. a& b. b& S3 I
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22.1 Introduction to viruses and cancer- n. r  K" _5 q5 O" X

: t3 o0 g; |% A3 N$ Z3 k22.2 Papillomavirus-linked cancers
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7 B8 |% B% u1 [) m9 c: l/ ]22.3 Polyomavirus-linked cancers3 c/ P" |. h! q/ \$ C2 N- i
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22.4 Epstein-Barr virus-linked cancers
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22.5 Kaposi’s sarcoma
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22.6 Adult T cell leukaemia" L" b; o/ x& \) v

2 `4 ~% B. ^" s& i! C: o4 z9 K+ Y+ \22.7 Hepatocellular carcinoma
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22.8 Virus-associated cancers in animals+ X1 A5 G% T3 n5 L
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22.9 Cell lines derived from virus-associated cancers.# l# N; r- d- ~: _7 c/ R7 K+ H3 l
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22.10 How do viruses cause cancer?
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22.11 Prevention of virus-induced cancers.& a, x4 G  v( D

$ @7 _+ D) e- x' C23 Survival of infectivity.& z2 G4 N6 m  _9 n. D" F$ S
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23.1 Preservation of virus infectivity.9 O2 z( W5 S/ Q
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23.2 Destruction of virus infectivity.
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23.3 Inactivation targets in virions.
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/ V; I. R8 y- n$ b0 p5 y23.4 Inactivation kinetics.
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- w% N1 L0 q, U6 y0 }23.5 Agents that inactivate virus infectivity.
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24 Virus vaccines." K+ j& D! {2 W# K: |
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24.1 Introduction to virus vaccines.
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24.2 Live attenuated virus vaccines.
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9 B3 s; Z! O5 y; f, L+ j2 N24.3 Inactivated virus vaccines.
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* d( C) \6 A; s9 o  P0 F24.4 Virion subunit vaccines.
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24.5 Live recombinant virus vaccines.% m6 L5 S7 V7 @( S5 e: L
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24.6 Mass production of viruses for vaccines.
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24.7 Virus-like particles.3 z" w% I2 ^* K' b5 t
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24.8 Synthetic peptide vaccines.6 x7 w% M* y; V' x% B) X3 i

# }. u- L. y0 ~6 y9 ]2 K# |24.9 DNA vaccines.
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24.10 Storage and transport of vaccines.
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25 Anti-viral drugs.
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! e( M$ A2 A4 }9 |* R+ `25.1 Introduction to anti-viral drugs.
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25.2 Development of anti-viral drugs.. P: x3 @! d- p/ q0 u7 Y7 v
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25.3 Examples of anti-viral drugs.* `; @4 s) q, L, }+ X5 E

' d: S0 k/ D! L25.4 Drug resistance.
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* N: u: A$ R$ H& y1 ^* F7 G25.5 Anti-viral drug research.
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% [% D/ q/ }+ A6 O26 Prions.
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) X' @3 l* `! M* b/ o+ _26.1 Introduction to prions.
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1 v9 z+ A  V% K1 u' ^6 y26.2 Transmissible spongiform encephalopathies.2 Q* \6 f0 H( z' \" I5 O

: Y  N$ B  W2 F( S26.3 The nature of prions.2 |% I* r4 X2 [$ @1 p
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26.4 Prion diseases.
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26.5 Prion strains.
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3 @9 P3 c' k* u/ S, a26.6 Prion transmission./ O; ~' K  A" e9 _( t4 C; [

& f% N2 y4 @4 o8 Q% j1 A5 ]26.7 The protein-only hypothesis.# f: Z$ A7 q6 ~2 i% w* l

9 Y) H! J1 n  \. W" a; t, S- J  }& YLearning outcomes.
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Sources of further information.
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Virologists' vocabulary.
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1 J' K2 e% m0 m; G$ ^! rIndex.

subenjinwo

好书！

yangpan521

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chleiwu

学习

tait1

kankan

zorro

3qqq

zzc2211

好书，谢谢楼主分享

白色的风

谢谢楼主

susannajoke

好东西

stem_cell007

kankan