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[干细胞与细胞生物学类] 再来一本病毒学经典--Virology:principles and applications--John B. Carter  

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发表于 2011-7-14 17:27 |显示全部帖子
本帖最后由 细胞海洋 于 2011-7-14 22:01 编辑
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, N& `% n* q* p5 gVirology - Principles and Applications# y- U2 k4 X- B; J7 t% a8 `3 ?
Dr John Carter (Liverpool John Moores University, UK), Prof Venetia Saunders (Liverpool John Moores University, UK)
  l+ F/ u) Y0 _% G4 |/ wAugust 2007, ©2007
8 @5 M' {) I- ^* x: `3 Cby Dr John Carter, Prof Venetia Saunders
* _2 m# o" M) F3 GISBN 978-0-470-02387-76 r! v1 _2 D, B: M; B% N* v0 K
Preface.
; [& d4 |3 U) E$ u' p! I1 l0 q% n1 c6 y0 T: C" Z2 Y8 z' J
Abbreviations used in this book.
$ ]& N) c, S, @. T! o: O5 y& Y. g
Greek letters used in this book.
# Y8 o% E6 ?' i, K2 Q: h" s9 c  j4 l0 Q' ?" X1 w# f
Colour coding for molecules.
0 K/ m& U2 ^1 n. Y9 I1 K  K6 I5 a; L$ U) G: u* H6 g4 i# e
1 Viruses and their importance.
3 y: ]( Y0 F0 }& G
0 |7 H, S& K; f3 J1 n( r% b1.1 Viruses are ubiquitous on Earth.
. R0 m! K/ [3 Z! h
/ T6 I* Z# j0 c1.2 Reasons for studying viruses.
; h6 J: i0 m- j8 J& l# }
: N7 e+ |! T  [+ I8 X1.3 The nature of viruses.5 K/ b; C$ f# o9 {1 C. C
+ F6 Y8 e: S; H, F/ v3 h: k
1.4 The remainder of the book.( `7 j, v$ _7 M; Q! E$ W. [

8 Z3 [( d6 J. N2 {, A5 A1 Q2 Methods used in virology.5 R0 x" n0 H  F' n8 {- D0 D: {: l3 \
3 m9 u; Z' M; v  c6 B" V
2.1 Introduction to methods used in virology.- v+ t2 J! e0 l, R
% }7 d- d1 v: m/ i
2.2 Cultivation of viruses.
$ D7 @$ s& F) }" a' e
* c7 i# \3 y6 B2.3 Isolation of viruses.7 i5 r; ]  T- ~! D6 X7 r

* q: q% o* N5 N. M: N/ O2.4 Centrifugation.
3 j9 x- P8 t% [3 g7 ?" D! A
: M, i5 L7 p: z, n+ n$ p4 r- n6 H2.5 Structural investigations of cells and virions.6 \" p  \% @. M# r; p, c
& k6 {$ E( ]5 J+ @+ g& u
2.6 Electrophoretic techniques.5 Z7 |+ C, A8 ?5 |

5 v  o; [  ~) a, m2.7 Detection of viruses and virus components.
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; i% A- A8 V( P7 F  I6 r2.8 Infectivity assays.7 [2 P6 Y% @7 W5 }* b4 ?% y3 F

) x. K, b! f; V# J' M2.9 Virus genetics.4 }$ c/ X1 e3 T% v7 {: ^3 n0 _

! q! S( `, a9 l3 Virus structure.
- ?0 d% x* l& T' h7 ?
. b* Q$ G2 k6 u( G3.1 Introduction to virus structure.
  ~/ z, z! p: D, M- X% \% x
- Q8 l( r5 V; g6 p! A5 }3.2 Virus genomes.
' {' h; ]6 i2 @$ |. X& i
3 X- o8 i5 @  G! K  t3.3 Virus proteins.% {! t! j( T; b5 }0 d4 R5 `5 p- b8 X: ~( |
$ c9 I9 o$ ~1 M" ^& c! }0 ?& G
3.4 Capsids.
7 l0 t" x2 B6 S) l% K9 W/ \2 F
3.5 Virion membranes.5 P* p. n$ ], G0 C) ], o. d

" Q$ |' m) r# B7 ~+ B5 b3.6 Occlusion bodies.( \- G6 I' e, m: D5 D
- s3 \' B. S) c: G6 }
3.7 Other virion components.
4 n$ r, O: m9 V; ?0 X" B5 p* H& t& ]  K7 \: ^" V
4 Virus transmission.
- A* d9 q, ~- ^; L, j+ C. B( ~
- T) |0 \+ v" }- i2 _9 C4.1 Introduction to virus transmission.
# ^1 b7 o" v% [
- b( d0 _; ~% `1 e4.2 Transmission of plant viruses.
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4.3 Transmission of vertebrate viruses.
6 G! A. n' z& r) Q; U; @( J# y5 {  x2 {% b3 k
4.4 Transmission of invertebrate viruses.7 e( `5 ]6 z( k! k% {6 _

3 J+ O  W( I1 J" F2 S4.5 Permissive cells.* g1 }5 Z4 U1 j* v" w- c4 w0 i
$ P/ Z0 w$ w9 G3 h
5 Attachment and entry of viruses into cells.* R. I' J6 w- o& Z4 n. O

9 p. W: E' {' w# ~1 N( b$ c5.1 Overview of virus replication." o7 O5 {4 f+ x# I1 U
8 P, h/ K# x/ Q( L1 ~$ \6 {
5.2 Animal viruses.
& _7 V$ A- Y9 B9 `8 J: f5 ?5 `- {' d& U
5.3 Bacteriophages.
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8 F) U- f" B- R# P' J5 R: i1 f6 Transcription, translation and transport.
# g; D1 d1 V1 @# r7 V9 ]  u+ w  a3 b
6.1 Introduction to transcription, translation and transport.  j! r( d$ R- Y8 a. R- ?9 I
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6.2 Transcription of virus genomes.* w* N4 n0 F, ~6 M! g2 E+ ?7 P/ u
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6.3 Transcription in eukaryotes.* g- B% c; B# ~5 a: b
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6.4 Translation in eukaryotes.# G& b. `+ U4 A% t

7 x1 s7 Q! X( q5 y6.5 Transport in eukaryotic cells.# i  B; u3 C; E( U4 C( {0 M
" ^6 @8 d- p7 @+ C
6.6 Transcription and translation in bacteria.
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8 Z0 z: V; P3 G, C# P: L& _$ A6 b3 g7 Virus genome replication.
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7.1 Overview of virus genome replication.
5 G3 T* ^$ U$ s; P: z. a: D# I- _9 Z9 m6 x  S) L
7.2 Locations of virus genome replication in eukaryotic cells.
9 F6 k6 D. _1 [: J
3 [- @- O" R6 m- h7.3 Initiation of genome replication.
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' M  I7 \! d& i) t7.4 Polymerases.
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4 C! U) e; `% `8 h8 H; A: c; I7.5 DNA replication.
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1 s) f/ E6 _; c( H, T8 B# A$ F0 k7.6 Double-stranded RNA replication./ z; E2 b+ Q9 s5 B) @2 U

  o/ [: f/ ~! P  U7.7 Single-stranded RNA replication.
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+ t/ t0 Y8 C: e* U7.8 Reverse transcription.4 t! K" G2 H3 D( m3 m; P

6 c1 F3 r! T8 S( r2 a4 ]& P8 Assembly and exit of virions from cells.
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1 O+ h, u0 A+ n' m5 C  W1 u# W. `8.1 Introduction to assembly and exit of virions from cells.6 D( T8 x9 K" R1 \0 ~2 i. X* y  d& j: J# F
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8.2 Nucleocapsid assembly.
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( g+ s. _* e; U4 J5 `  l. x8.3 Formation of virion membranes.% o$ s  p1 o6 V. \9 B

" R( Y2 V) {/ d; N" Q, F. d" M8.4 Virion exit from the infected cell.: u% p! Z8 Y+ {+ m. }* w, t! _
# G( P7 B/ @* \* N
9 Outcomes of infection for the host.: u$ v6 q% S& h* r

# F- n4 `- a* C9 L! n! Z4 a1 J9.1 Introduction to outcomes of infection for the host.: I; U5 @7 J" d

; f' W- {3 W4 y; g9.2 Factors affecting outcomes of infection.( V; y3 R4 b) y+ q7 v8 n' S
6 E; v- p0 \) u6 K$ y) V
9.3 Non-productive infections.
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9.4 Productive infections.3 I! e; B' M3 M) u5 Z1 W  q( _

. |' _5 p% M  `1 @& q3 A! H10 Classification and nomenclature of viruses.
  I; H* \: v) L0 T2 H$ z. M* a8 y( V6 S  p/ g9 O* l
10.1 History of virus classification and nomenclature.
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10.2 Modern virus classification and nomenclature.6 m% P$ ~+ W9 H$ U

( X5 H( i# _2 f! {10.3 Baltimore classification of viruses.
) M' X& g& y" B3 ]
5 k' ~0 C" N0 u! Q4 m, x& `11 Herpesviruses (and other dsDNA viruses).3 ~4 U( }8 B! y+ R' p

5 t* `( Z8 D5 _3 |11.1 Introduction to herpesviruses.7 r% H1 B+ [7 D8 F
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11.2 The human herpesviruses.
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11.3 The herpesvirus virion.# G6 l; k* `: v$ a/ {# F0 A7 E
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11.4 HSV-1 genome organization.
: {9 k. E3 C0 e! X( F/ T5 i
6 J/ f) p( M2 ?; G% M; h& k11.5 HSV-1 replication.# s  b* z6 ~& z( o, e: k) I
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11.6 Latent herpesvirus infection.
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11.7 Other dsDNA viruses.0 G, p5 X! p& }4 r6 _+ W

3 O, m$ |5 ~- w1 J12 Parvoviruses (and other ssDNA viruses).. u& l$ R0 N+ F, E! N6 m8 K
- V! i! F6 X. M3 |7 P2 i' U
12.1 Introduction to parvoviruses.& x3 m) i7 O8 ?  f6 e& _" l
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12.2 Examples of parvoviruses.
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) o3 M2 `' f3 V: W12.3 Parvovirus virion.
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6 i# F& g7 S* q6 u% p12.4 Parvovirus replication.8 O8 k* G0 }+ X4 n  N
! P( [" Z3 I5 l1 z/ ^
12.5 Other ssDNA viruses.% p! M) [& Z/ T" V" ~

: O* B8 N) `& w13 Reoviruses (and other dsRNA viruses).
) @1 z( J& h$ c# H+ c, d7 P! A$ \0 e; ~
13.1 Introduction to reoviruses.
- `+ M2 G& a: _' t+ M6 ~: [
8 d' @+ I; c$ D3 a/ h: w13.2 Rotavirus virion.; C& r4 Q# j9 ^+ t0 U

1 \2 O: K9 N* {  P: p9 [1 A: P7 t, `13.3 Rotavirus replication.
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13.4 Other dsRNA viruses.
; u) }( ]1 e. F% c$ L; Z- l7 Z# I* b* l7 |5 q
14 Picornaviruses (and other plus-strand RNA viruses).
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5 J# p5 }$ j1 i! e, U14.1 Introduction to picornaviruses.
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3 M5 e4 q; y, m" i  z0 K7 Z9 Y& l14.2 Some important picornaviruses.$ u1 }, r- n2 x: B6 ?
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14.3 The picornavirus virion.
, e5 f' P9 C/ Q9 {" V; \
) _& c2 m2 ?9 r5 r14.4 Picornavirus replication.
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' s* k0 d' w8 V0 a14.5 Picornavirus recombination.
& X. @# ~1 Z1 j: ]2 |, L) ~- [) e
14.6 Picornavirus experimental systems
' q3 ^1 x6 k1 H
# k  W9 A0 Y7 p9 v14.7 Other plus-strand RNA viruses./ _! d2 d- n" X* U' V% q
6 h+ M  \- `) M1 C5 M
15 Rhabdoviruses (and other minus-strand RNA viruses).
1 s1 g' @3 d% n( N, g0 _& C  t, \3 l- C9 }5 y. q/ _" Y+ l
15.1 Introduction to rhabdoviruses.
# S1 T& L" ]3 D' w- h
( B0 l4 x0 Q! G% O15.2 Some important rhabdoviruses.
2 o" L5 @; A5 g, V! m9 q
8 ~7 V- q$ i$ F0 z15.3 The rhabdovirus virion and genome organization.
) C4 s8 X" {" ]' ?; z) G- d/ W! A* t. r3 J2 T' }5 Y
15.4 Rhabdovirus replication.
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. z* Z' v$ I& j( u  e6 k15.5 Other minus-strand RNA viruses.
- z# T. _! W! H' S0 z8 N2 e% d1 ?& y: I
15.6 Viruses with ambisense genomes.. F' \# f! y* T$ K* B
2 q1 v1 f' |% _5 I
15.7 Reverse genetics.2 ?0 N; M0 j) b) K6 S. S

$ l2 U  h% r3 K% n# T7 B8 U+ S16 Retroviruses.
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" G. l, _8 E5 O# w16.1 Introduction to retroviruses.
& J( B& `$ j4 E$ P8 r5 n/ X# E, L2 h9 Y8 ]% v! P9 E; l  Q) |$ I( a
16.2 Retrovirus virion./ p* j% }; o; V( N
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16.3 Retrovirus replication.
( Z; c% r: W* [7 D  I  G% X! K8 a+ m+ }
16.4 Examples of retroviruses.
% s9 P* G, `1 v1 q) O2 b  e$ s# l4 Y! g0 ]
16.5 Retroviruses as gene vectors.* Q  ^8 _6 ?" t/ W: i7 b
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16.6 Endogenous retroviruses.
; G  @$ w8 `8 {1 q0 [3 X, w8 h/ G! j, |
17 Human immunodeficiency viruses.* F4 v6 e" s  p5 [+ W0 M4 w( c
. v; Z* M! s% x% Y! R
17.1 Introduction to HIV.
- {! C- d0 w9 B0 `
; U) d" L. _( E17.2 HIV virion.% g. i% ]5 T0 _% n
6 x/ o7 ?. W8 v; B! F
17.3 HIV genome.- V! l2 g) J2 I% y
; T) y& N  Z. K8 e- \* n
17.4 HIV-1 replication.
$ Y  o( b7 L+ {2 r0 P
# A: g0 M; e  ~9 J4 N/ ?17.5 HIV-1 variability.
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17.6 Progression of HIV infection.
. g" H. J- U7 L2 ^" T" [6 q1 R$ t" @- z8 j/ g( o3 `
17.7 Prevention of HIV transmission.
* V% h5 f# b$ w3 A* D: \; I; J, `& d, c( |/ ~& M# a( H
18 Hepadnaviruses (and other reverse-transcribing DNA viruses).! J0 @0 j3 s5 f8 X3 X+ p. `& d
+ M4 }4 ~' f7 n, y0 S. X1 ^3 }/ t, F) ^
18.1 Introduction to hepadnaviruses.4 ]- H2 t) |  [3 m7 {: ^
) U+ D1 p2 l1 i- D, Z& v
18.2 Importance of HBV.; A/ W' |0 v. T' [6 _& U" Q! J
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18.3 HBV virion.. I' @6 w% M, o/ y
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18.4 Non-infectious particles., C+ `! O2 u6 p
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18.5 Soluble virus protein.
" D( Q8 g) v: J  d7 f! t( p. |8 g: s0 E4 l: r% z% |! E
18.6 HBV genome.
+ ]! [0 c$ `. A# F$ A8 x
: ~  J9 k2 s8 `, D! N18.7 HBV genetic groups.
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18.8 HBV replication cycle.
9 u- f4 l3 h6 A$ m7 D
" J9 t# V2 o: A. p/ P: V18.9 Prevention and treatment of HBV infection.
* R) x, Y  G7 m
- p3 a! f" m4 L7 N& c  k7 r18.10 Other reverse-transcribing DNA viruses.
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19 Bacterial viruses.
" q  P& V6 M! K5 }) M+ V9 L" \' ?7 l
' }2 z5 }, o9 O, M2 C- a5 O4 Z% J& v19.1 Introduction to bacterial viruses (bacteriophages.5 P  k7 Z: C/ J$ [" P9 _+ o

' r, ?1 J+ \# Z8 n& Z8 pRNA PHAGES.' ^; M. {! G& U  Q

) ?' h, P& f/ e19.2 Single-stranded RNA phages.% V3 w+ {7 P/ q, h* i: R1 {# }; Y

' [9 E9 L$ l: P4 q3 |" R/ ]19.3 Double-stranded RNA phages.
/ D: n7 `- c7 [( D1 `/ U4 W" b6 G- Z5 k( K. S
DNA PHAGES.5 q; `1 j* l8 q/ O6 Q6 b4 g1 u
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19.4 Single-stranded DNA phages.5 X) d- i# _' |- o( S6 {
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19.5 Double-stranded DNA phages.
6 u$ j. l8 n4 T" n% u/ A+ {" H6 C. D: P0 P1 b
20 Origins and evolution of viruses.
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21.1 Introduction to origins and evolution of viruses.5 t# h' b% k# Q) y8 q5 u; C
* S5 y2 y+ G, l9 _
20.2 Origins of viruses.2 B1 z2 c5 H  v+ G1 i6 u
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20.3 Evolution of viruses.
9 V/ ]& c+ f# k* n) u3 h) F. a. v: J6 R6 P$ e6 m( K0 D
21 Emerging viruses.
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21.1 Introduction to emerging viruses
$ ]/ Y. r2 n- f) f4 r, `  X' k/ S6 N  g+ b7 ?8 N1 Y: `* H( d, p
21.2 Viruses in new host species
2 `  V& m% F9 N# S4 u8 T  ?7 X5 V& v* n; Z1 G
21.3 Viruses in new areas, X1 Y, K: _. v/ a
& Z2 O5 ?: w& z- {
21.4 Viruses in new host species and in new areas! ?; l( a3 `* R  ~$ P
( `& q: A) n3 z4 X7 p* b' [/ x
21.5 New viruses4 [0 e8 H9 q# J

' h  G' u: q  h$ m1 P( z# V21.6 Recently discovered virus; {$ G: E; N- h; Y5 {' v  X6 e
+ w  Y' L; C7 e% @9 C9 C& c3 e
21.7 Re-emerging viruses) B8 P- ?5 j0 y5 g# N& [, c, c5 u

( ]( a2 M4 c9 p9 |, X21.8 Virus surveillance
" T8 p& r( m3 R5 n) a8 [# K* f. Q; U1 w$ n
21.9 Dealing with outbreaks! v( F4 X, A/ l' Q

* t. [* F7 l4 [( N: M22 Viruses and cancer* l" M# D: H5 K8 s- S' E1 X- t, r
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22.1 Introduction to viruses and cancer
7 ?/ |: u5 R. @: q9 d" J: ?& a7 R
+ x  @2 A9 K* ]3 e22.2 Papillomavirus-linked cancers
1 |  ^% P( ?, |0 E0 ~2 {: Y" \$ I/ [" f5 [! }2 N3 f7 V
22.3 Polyomavirus-linked cancers
2 m8 o( ?3 I3 J# w5 ^; |& T2 C1 k& L4 h
22.4 Epstein-Barr virus-linked cancers
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22.5 Kaposi’s sarcoma
# I6 U- `. [# k/ U7 r3 p* E! J- X' P1 U/ x
22.6 Adult T cell leukaemia& C+ F4 Z# V5 L2 y

9 b- l2 L9 t9 @0 x/ y7 b7 t6 c% s22.7 Hepatocellular carcinoma
2 Q- U/ M( K( b# n- {% R4 D
- H1 @' _# l8 j5 T8 n6 h( ?22.8 Virus-associated cancers in animals5 J3 T% @9 ?  K2 o. j6 d

7 x' m6 k* r$ ~; [$ X% B7 B# J; `- s22.9 Cell lines derived from virus-associated cancers.6 {' Q( R! o6 D% P

' @" F0 o& O% ?8 [8 P( T. S& `+ [22.10 How do viruses cause cancer?) _4 h$ J+ k' n$ v& K9 h
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22.11 Prevention of virus-induced cancers.: n/ g) S% L+ L
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23 Survival of infectivity.
, O5 f; l; g+ z6 X% K/ ^' Z/ h( P. o/ z
23.1 Preservation of virus infectivity.
2 Q% z0 x' \4 f1 x/ M' l! p
1 E& j0 I# P, [+ c23.2 Destruction of virus infectivity.0 C. F0 u# b7 ]. t
7 M& U- Z; A4 g* n
23.3 Inactivation targets in virions.
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23.4 Inactivation kinetics.7 u/ D, M0 l0 T; m+ `) D% J8 E

* E! v  ~2 N/ p" H/ m& T23.5 Agents that inactivate virus infectivity.
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24 Virus vaccines.$ P; q3 P" B% B* |+ `- ^

1 y6 C( |: @' J7 {6 d) {$ t24.1 Introduction to virus vaccines.0 Q: K/ w& \) E3 A8 u* l
2 o- e: x% L6 {, O
24.2 Live attenuated virus vaccines.4 c" \5 a* W" C2 _
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24.3 Inactivated virus vaccines./ B5 W. C0 |9 e, v" s) I- [

: A$ o3 G: h% h6 C* v24.4 Virion subunit vaccines.
3 l2 o8 m, u( g1 B! X( ]. G% J6 {8 @( h, p
24.5 Live recombinant virus vaccines.! z$ f( a. [! s; t* o. L
+ Q' f5 y# g7 e1 [6 E" F
24.6 Mass production of viruses for vaccines./ A7 H: S; P4 D, t3 Z5 i# x* ]

# E* C9 u5 n. @) S0 Z24.7 Virus-like particles.
! v' ?  r! J3 Y9 N# s/ I  I6 X0 a7 V. _+ A
24.8 Synthetic peptide vaccines., a$ Y" f0 P/ N) ]9 f) Z
2 E2 C7 a' W  R* j
24.9 DNA vaccines.. n( p9 o0 l' [; \8 C- {
' {  N8 g7 r" D! P# V8 i
24.10 Storage and transport of vaccines.
* M: a) B; Z  W7 x& `/ Y, a3 O( ?! ]4 i/ t* }% h" o
25 Anti-viral drugs.
) G2 ^! Z  }9 T- y' V  d9 U! A7 E& v' E" z9 S( x8 J
25.1 Introduction to anti-viral drugs., l* D: y  x  q- z$ o

: q4 _' N: \0 [! X, |25.2 Development of anti-viral drugs.
3 i+ u8 |  Q  l; {4 l! E2 V/ K8 u3 F1 x6 u
25.3 Examples of anti-viral drugs.
- Q& F  l! h+ D6 k! c$ d
4 N' m+ x6 e* m25.4 Drug resistance.9 m0 e/ f2 h0 A2 Q* w
' C1 k$ U) U: e* K. S# J3 y0 @, z
25.5 Anti-viral drug research.
! c9 w8 D: G7 p# ~
: b$ Z, ^8 v& \3 ]9 p7 \8 |26 Prions.; ^" O  C% C% q# r
0 A7 p3 |- Q8 t# L
26.1 Introduction to prions.
8 A* @( b& q  ]; s3 |6 W
* F, O2 r) \# B6 p. h26.2 Transmissible spongiform encephalopathies.3 C( u% H% O: p% E6 w0 X; l

, N7 t6 S& \* I- x% Z2 _7 h8 M/ j8 H* I26.3 The nature of prions.1 f- a' e% Y2 m/ I

6 t8 D7 H& {8 J/ I26.4 Prion diseases.
! n- d; N% \+ Y8 M8 w$ R! _8 a- y8 u+ @
26.5 Prion strains.
: O: j4 F' T& r/ ~
' I9 [0 ~8 |2 Q0 n26.6 Prion transmission.1 K! Z* g  m  A
$ P2 Y0 I  b1 I. O- ^. B" I: l
26.7 The protein-only hypothesis., P% |' P  {* y7 q  {, w0 g7 `& E
% p' B$ x; M+ F. S9 R4 f+ C
Learning outcomes.  ]: z$ }* F% W( O! v& S
, o; C! @9 N$ w' v6 T
Sources of further information.0 \0 Z4 a" n% U; i# w3 i) q/ R
$ z7 G$ J5 _5 t4 H; e8 m
Virologists' vocabulary.1 d1 G  k4 r# P* b' u
5 N# z1 ?& [4 g- U& z1 p4 U
Index.
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