再来一本病毒学经典--Virology:principles and applications--John B. Carter

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$ a3 n$ ?; r6 r+ P! rVirology - Principles and Applications
! M' d8 o4 B8 e+ O- bDr John Carter (Liverpool John Moores University, UK), Prof Venetia Saunders (Liverpool John Moores University, UK)3 q& s" O+ o& G" N. r
August 2007, ©2007
- [5 |$ X$ {8 D% _. a" {, nby Dr John Carter, Prof Venetia Saunders7 r, P) [, ?' J+ J6 I
ISBN 978-0-470-02387-77 l$ p* a* z3 G* @
Preface.
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Abbreviations used in this book.5 E# z+ M* h# ~3 o9 ]

% A% v) G0 ]+ [Greek letters used in this book.# i! M: v# l! l+ R3 |9 ~6 R

, h" s; l% p' _& V9 W/ [Colour coding for molecules.9 d% |* T6 Z1 U9 a0 y( w' ]4 }

9 |$ v; Q: }+ m$ ]1 D( l6 T1 Viruses and their importance.( w# B4 G. Z- W! c7 V4 w; x! A
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1.1 Viruses are ubiquitous on Earth.
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1.2 Reasons for studying viruses.# b5 E/ y, f6 V. e* A" r

3 Y+ O( q% P& e; H+ I, Q$ y, }2 p1.3 The nature of viruses.
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1 K7 W' c$ T, K/ O; ?! ^1 T* |1.4 The remainder of the book.
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4 p8 }. w8 v1 u& L0 V2 Methods used in virology.
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- _7 ~' V) ^/ X" F+ }1 h2.1 Introduction to methods used in virology.
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2.2 Cultivation of viruses.
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$ ?' L0 U/ a* i& g$ k6 |2.3 Isolation of viruses.1 N+ t+ F9 }8 B0 K! M/ B$ e1 p

: |2 v- [! G; k. g  `4 T0 Y7 o2.4 Centrifugation.
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! l) }$ u' o" G8 E2 G% ~1 ^% q2.5 Structural investigations of cells and virions.5 i$ d+ e1 t. m) g, s$ E
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2.6 Electrophoretic techniques.2 l+ k* U! T+ b* O" n; h( E0 X$ ^! x

  ]) W& U, A3 a( E* Y2.7 Detection of viruses and virus components.5 R& S6 y  H' M  X7 b3 b! _

  ?6 ^+ r/ B' ~6 z2.8 Infectivity assays.
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$ g' k! m* A0 d  n+ [; m8 M# s2.9 Virus genetics.6 V% V, J/ Y3 [1 g3 G1 P

. E4 s) `. G/ `+ W" O% d8 W3 Virus structure.
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/ L  _0 k: G: m4 J0 Y1 }3.1 Introduction to virus structure.1 M: Q. Z; W% j8 P
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3.2 Virus genomes.
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. i0 K3 q4 ^  i' C& G) F3.3 Virus proteins.
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& g' X$ A" I4 R3.4 Capsids.
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3.5 Virion membranes.. a+ i4 ^' y* b
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3.6 Occlusion bodies.
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% s7 b; e9 \# o2 H- d2 E3.7 Other virion components.
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( n+ f8 A, I" G+ y! E! }) W4 Virus transmission.2 T  E& [/ O5 R1 b' e) p; e
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4.1 Introduction to virus transmission.
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4.2 Transmission of plant viruses.7 H8 }; r) \8 x, c

, t9 e& X6 v/ K( _7 R5 N: M* Q; V4.3 Transmission of vertebrate viruses.% a4 _  D6 W) @% B+ z4 y7 k' ?

: X6 p5 ^; P% J+ ?# c% Y4.4 Transmission of invertebrate viruses.
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& s2 Q1 S/ g6 w' O% \) F- q& O& N4.5 Permissive cells.
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2 {6 k" N4 F* S$ E5 Attachment and entry of viruses into cells.
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& K4 X2 J8 A' @) @5.1 Overview of virus replication.
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) k0 ?3 i! d% L2 `; c1 S2 P4 Q5.2 Animal viruses.  r1 p& Z  S/ h% }9 P7 `
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5.3 Bacteriophages.! M9 V2 F; r1 C, a! ?

) ?8 w" {) E) n( r6 Transcription, translation and transport.( e& Z' f; Q& o+ _, j: O
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6.1 Introduction to transcription, translation and transport.) x$ O& O! M6 W4 s! B3 j3 ?
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6.2 Transcription of virus genomes.# U- e7 u) w( T, m  a& D/ i
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6.3 Transcription in eukaryotes.5 b3 W1 L) r" F+ N! j/ |
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6.4 Translation in eukaryotes.
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6.5 Transport in eukaryotic cells.
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8 l( F; r7 T0 w0 I) l6.6 Transcription and translation in bacteria.
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4 y5 \- J, W9 ~7 Virus genome replication.
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* ?2 @: A5 T# t& }) K. Z8 n0 S7.1 Overview of virus genome replication.
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7.2 Locations of virus genome replication in eukaryotic cells.& U. t2 c- ]3 A( V( O! g+ H

" y9 a! R; ], {6 ]( j7.3 Initiation of genome replication.# Y3 v0 b" Z" J# i. G  Y8 L0 x
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7.4 Polymerases.( L: V) Q! I4 t$ ]2 w
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7.5 DNA replication.
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7.6 Double-stranded RNA replication.
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* V0 u' v' f4 Q7.7 Single-stranded RNA replication.
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7.8 Reverse transcription.0 f8 H  O# j( @) H6 {
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8 Assembly and exit of virions from cells.! s: G& r! M& f$ B* e- I( ?9 P; M

$ z% u# n6 f5 {8.1 Introduction to assembly and exit of virions from cells.. V4 V1 n# F7 ?. j$ W) y/ [
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8.2 Nucleocapsid assembly.
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8.3 Formation of virion membranes.
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( Q& u+ x" t2 ]4 i  m" B) I4 W8.4 Virion exit from the infected cell.
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9 Outcomes of infection for the host.0 u+ p6 j" L4 r6 ?& m% S( K" g* p
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9.1 Introduction to outcomes of infection for the host.$ A; z  B+ Q+ D

, R# f$ t% ?5 \. V; K9.2 Factors affecting outcomes of infection.
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9.3 Non-productive infections.
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* n4 N/ R7 g2 v) P9.4 Productive infections.! ^/ m* M8 t* R
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10 Classification and nomenclature of viruses.. ]2 ]* Z( D% l" L& i$ _
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10.1 History of virus classification and nomenclature.
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10.2 Modern virus classification and nomenclature.
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) i, {5 Z) ^0 r) N10.3 Baltimore classification of viruses." A, _2 w7 {% H" r8 f6 v2 s, @

* I, b- v4 l4 _% k9 `9 q11 Herpesviruses (and other dsDNA viruses).
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+ @2 }& @$ m$ J8 K4 l- |11.1 Introduction to herpesviruses.2 _, \: I5 u5 J5 d/ Q0 i
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11.2 The human herpesviruses./ r% x; f: o7 Q* w! Z
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11.3 The herpesvirus virion.
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# j, E' ]' O1 O0 `) m# z# Q$ R11.4 HSV-1 genome organization., i' O3 H& n8 E* ]" W' B1 g1 k
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11.5 HSV-1 replication.
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11.6 Latent herpesvirus infection.
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11.7 Other dsDNA viruses.
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12 Parvoviruses (and other ssDNA viruses)., H9 }  p1 M4 ?6 {4 _$ h

1 L+ ~* u' R3 k1 }12.1 Introduction to parvoviruses.6 _* @  c' \" n- ?. @+ l

  s) g+ [0 ~! \! m! Y, ~2 r12.2 Examples of parvoviruses.
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! l* T/ Y5 P; l* ]8 ?/ I! B8 R12.3 Parvovirus virion.
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12.4 Parvovirus replication./ u9 S, L) N1 ?. [% K( K3 @0 z8 b

4 y# q* P( P  p4 G. A) S2 @9 x3 \12.5 Other ssDNA viruses.
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  \: e6 [  E6 B$ g5 ?13 Reoviruses (and other dsRNA viruses).
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13.1 Introduction to reoviruses.0 _5 T/ E$ j& ]! a* h' v! I  {

$ K$ \$ K8 D5 M& o# ^8 W13.2 Rotavirus virion.9 O9 i5 }/ N) C* f+ H( E

- t( ?) i% N+ y( l13.3 Rotavirus replication.
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13.4 Other dsRNA viruses.
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2 M4 |9 t/ D5 C( j2 h8 ~14 Picornaviruses (and other plus-strand RNA viruses).
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14.1 Introduction to picornaviruses.
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14.2 Some important picornaviruses.! O9 @8 \+ s( i- r8 u: ~9 |
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14.3 The picornavirus virion.! s8 M2 W5 N. O$ D, c+ H# k0 `

- F. P5 C2 f8 J) K! Q/ M14.4 Picornavirus replication.
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9 V7 U  f# O" Z5 l14.5 Picornavirus recombination.
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- A; g" {+ I% k& g8 I14.6 Picornavirus experimental systems* _1 g8 g* k) q( t& b  o

; Y9 a4 v: g  ?: \5 o6 ^14.7 Other plus-strand RNA viruses.+ |7 I( |  }# |6 W4 O& o% N) |  a' T
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15 Rhabdoviruses (and other minus-strand RNA viruses).1 {+ S& f8 a7 R: ?

+ [1 ~9 H7 b7 y1 p6 x15.1 Introduction to rhabdoviruses.
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  a2 ]) r, K5 P7 l  ^: A! r9 ]' S15.2 Some important rhabdoviruses.' |4 N7 |, d0 `* _4 e2 S) p

( w6 }: ~. x. G) b15.3 The rhabdovirus virion and genome organization.; g$ a8 g3 p/ {0 E& o3 ]7 g

+ o& R0 b, I- V! t' w; O15.4 Rhabdovirus replication.
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15.5 Other minus-strand RNA viruses.8 \' I3 w. i. I: R/ s/ Z/ t5 B+ H

' X) @6 ^* P6 Y9 D$ L; E" T15.6 Viruses with ambisense genomes.4 W& p* d* I" u6 Y; P% h

2 J7 J& s- _5 Y1 Z15.7 Reverse genetics.
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16 Retroviruses.
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% `1 q' I! x, h0 z16.1 Introduction to retroviruses.
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16.2 Retrovirus virion.
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16.3 Retrovirus replication.
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6 u: i5 M5 l$ C+ _+ m& E/ e! @' a- R. C9 L16.4 Examples of retroviruses.# w3 ^/ ~$ ]4 {9 b2 q3 f9 r
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16.5 Retroviruses as gene vectors.) X* x0 W: O; e& W5 y. ~: {0 v7 |
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16.6 Endogenous retroviruses.
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  X+ I% F: o" H3 x; a; c% p; |17 Human immunodeficiency viruses.
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17.1 Introduction to HIV.
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17.2 HIV virion./ F4 C2 `$ _( _, f, `

0 l+ K$ t) V9 x5 q: s- ^17.3 HIV genome.$ e! f4 C  b3 G' X% p. g8 ?2 A7 R
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17.4 HIV-1 replication.
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6 R- P' k9 A2 T0 M17.5 HIV-1 variability.
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17.6 Progression of HIV infection.: t( t4 G# B  n' A6 g
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17.7 Prevention of HIV transmission.
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4 a) t0 u& z  D+ {% `$ E, m9 {18 Hepadnaviruses (and other reverse-transcribing DNA viruses).$ X2 o+ W. ^5 L+ N
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18.1 Introduction to hepadnaviruses.
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18.2 Importance of HBV.0 F* c, O8 Y0 U7 n2 {
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18.3 HBV virion.: {' P7 h2 I* n- N. l
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18.4 Non-infectious particles.: A/ i1 l2 Y$ ^1 o3 R9 m+ d
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18.5 Soluble virus protein.( W6 w# N3 _  e/ N
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18.6 HBV genome.
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6 e; W2 h, H4 i- U' B/ M4 `18.7 HBV genetic groups.
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18.8 HBV replication cycle.5 y2 D) B# {$ E1 f

: q( W2 z! C2 E; q& G. v3 p18.9 Prevention and treatment of HBV infection.
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% n- @5 k; T0 H+ b4 M: t. ?" ~3 `18.10 Other reverse-transcribing DNA viruses.1 K# x' B2 H1 m8 \7 G- U. x

- B6 i& Q8 a' r& T) V' i19 Bacterial viruses.
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19.1 Introduction to bacterial viruses (bacteriophages.
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RNA PHAGES.5 e# K# w) p6 ?8 o+ l1 R
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19.2 Single-stranded RNA phages.
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19.3 Double-stranded RNA phages.  I  _$ s* D# E* e  n; {% |
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DNA PHAGES.
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3 c. g# z0 d0 k+ |19.4 Single-stranded DNA phages.( ?7 A- b( Z" {% a3 h

$ d% X7 x; i/ m+ ?+ |7 r19.5 Double-stranded DNA phages.1 k6 @0 I* Z0 w  i& W" A3 A+ w

# E1 U+ e) U0 H- H! l7 P20 Origins and evolution of viruses.
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$ F4 ^' t7 M/ b( @21.1 Introduction to origins and evolution of viruses./ j2 C& K6 K& f; E2 n5 }- g4 R' E
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20.2 Origins of viruses.3 b6 z$ U. D+ R0 `* {" T7 e8 v0 J
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20.3 Evolution of viruses.) o3 ^6 c' Y* z% X

4 p# X% L8 ?; _5 a4 h6 B" C+ y21 Emerging viruses.! ~4 {$ {- r8 v: d

% ?0 d+ A4 L4 Q! X7 t21.1 Introduction to emerging viruses
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21.2 Viruses in new host species- O( {- d, c, Z2 I1 [/ o
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21.3 Viruses in new areas
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9 ~+ I  `8 f  G9 d! \: X21.4 Viruses in new host species and in new areas/ M4 N! ~; B5 j: g7 F0 C' r

4 y  J5 q7 w. {- F# `1 X21.5 New viruses: u; f, N8 b4 y1 K& l5 W  N" U
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21.6 Recently discovered virus
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+ m$ j9 ?# ?( |5 n% @7 G) `21.7 Re-emerging viruses
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21.8 Virus surveillance# L' h$ Q4 c/ B+ O

6 Z" o& h8 H7 B' x& L; @21.9 Dealing with outbreaks
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22 Viruses and cancer4 m  X  v0 u7 `8 s5 W0 {

2 f8 X( `( U' ?/ g/ w% D22.1 Introduction to viruses and cancer( h! N" W' w" g  ]4 @

5 [! N  H* r/ K' k22.2 Papillomavirus-linked cancers; e: ^7 ~. _7 y( t

8 ?- Y; N2 W1 O- C1 n22.3 Polyomavirus-linked cancers
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+ C3 F# ^$ E. u# l) D. o22.4 Epstein-Barr virus-linked cancers, R" \9 R! L2 ?3 K, J; o3 V
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22.5 Kaposi’s sarcoma
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& I4 w& v$ o$ C' Y, j22.6 Adult T cell leukaemia
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22.7 Hepatocellular carcinoma
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% O3 a+ I! S, i2 D/ a- j22.8 Virus-associated cancers in animals% Y7 v# a& Y! l$ g  Q+ u
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22.9 Cell lines derived from virus-associated cancers.! Z$ v& Y1 n1 W

" H3 b3 s+ T; w8 z+ C2 V3 n8 }22.10 How do viruses cause cancer?
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' E9 T0 `5 T  M' c$ d22.11 Prevention of virus-induced cancers.
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23 Survival of infectivity.
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23.1 Preservation of virus infectivity.
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23.2 Destruction of virus infectivity.! v# K1 D5 r3 x& A# I) M: R
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23.3 Inactivation targets in virions.3 h6 g. u3 e( Q  C1 m. ?/ M

/ A8 K, o/ X* Q* B23.4 Inactivation kinetics.$ x( x4 o; d* ~/ v- Z
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23.5 Agents that inactivate virus infectivity.$ D( j7 D. |  p5 g8 s9 c
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24 Virus vaccines.7 h' J0 A( t- w. a  @5 c
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24.1 Introduction to virus vaccines.
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24.2 Live attenuated virus vaccines.. h( R" i: C& I0 f

8 h* g8 k3 r5 k2 R8 X, e" G& ~0 C24.3 Inactivated virus vaccines.6 U2 Z6 \# V$ r' c; g& i6 O

* @) U' R0 x* t0 z& f4 U24.4 Virion subunit vaccines.
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  B7 N5 l! y. `; Q/ ?  S24.5 Live recombinant virus vaccines.
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24.6 Mass production of viruses for vaccines.
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24.7 Virus-like particles.- z7 t& H/ y, r. D2 N: H) h9 B% H+ N
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24.8 Synthetic peptide vaccines.
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24.9 DNA vaccines., U/ l, G1 G! @. L3 y3 w
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24.10 Storage and transport of vaccines.
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' |* V" x9 c) L7 G25 Anti-viral drugs./ @: o! z9 K* m) l8 q7 U, W4 x2 e
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25.1 Introduction to anti-viral drugs.
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& b5 g- C1 \/ T  a$ }. s, N25.2 Development of anti-viral drugs.
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25.3 Examples of anti-viral drugs.% q8 u7 t3 N% j8 g3 H% |  d5 {

4 t6 O* l. O4 d8 a2 ~25.4 Drug resistance.# I. `0 y, F( R' q: ~: R

& a: i) J' q3 b. n4 ~' a25.5 Anti-viral drug research.* ~- i1 O' f0 k7 ]( M

( f) L' G, ]& I, S" J* e; p26 Prions.
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26.1 Introduction to prions.
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* u: B/ T+ X/ @+ }26.2 Transmissible spongiform encephalopathies.- ~  I9 W* L  |

" ]! b; E4 ^  O$ U2 `26.3 The nature of prions.( g3 [" U( \" F3 I! k6 w! i
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26.4 Prion diseases.
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26.5 Prion strains." [) `9 i+ f6 H& `
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26.6 Prion transmission.; N3 {2 I1 w2 ^3 S- Z: D

: h( Y2 C* y- p$ G1 e. U, {26.7 The protein-only hypothesis.
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Learning outcomes.
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6 c5 N* f* R- t' Y3 CSources of further information.
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1 S% Q1 i8 z! W& [- _Virologists' vocabulary.0 R; ?3 r2 p. p  M, M

( B2 O# X% |9 q% y; QIndex.

subenjinwo

好书！

yangpan521

回复 dahui 的帖子
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chleiwu

学习

tait1

kankan

zorro

3qqq

zzc2211

好书，谢谢楼主分享

白色的风

谢谢楼主

susannajoke

好东西

stem_cell007

kankan