再来一本病毒学经典--Virology:principles and applications--John B. Carter

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& I6 |& e% u9 U' h' B( E. X [hide][/hide]
; ?; _& y3 ^3 PVirology - Principles and Applications
5 c% {3 f. g- h5 B* b5 _Dr John Carter (Liverpool John Moores University, UK), Prof Venetia Saunders (Liverpool John Moores University, UK)
, t2 b( `) f6 q) M5 a" x/ d+ [August 2007, ©2007* t% r& a8 f1 D  k6 i" m: [# f
by Dr John Carter, Prof Venetia Saunders+ @) ]0 D8 M7 S2 r7 M9 n
ISBN 978-0-470-02387-7
) k7 ~! y5 J/ H: _) [Preface.
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' D/ C8 A9 K' r- w+ r5 U# aAbbreviations used in this book.5 E0 L. n' Q4 e' m/ j) w, j1 I

: ?: R3 G, O( d7 X& x* sGreek letters used in this book.* o- D; ^/ `; N3 N& M" J  Y
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Colour coding for molecules.
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1 Viruses and their importance.
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1.1 Viruses are ubiquitous on Earth.
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1.2 Reasons for studying viruses.: V4 \& ?! J3 J# j

$ u* f0 l& A& s1.3 The nature of viruses.
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& |  X( D" d* ~! t  C1.4 The remainder of the book.: Y' V1 I$ D) H- i& T6 I7 r6 F3 b2 l
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2 Methods used in virology.
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2.1 Introduction to methods used in virology.
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: t/ ]+ E% _7 a* ^. M2.2 Cultivation of viruses.
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2.3 Isolation of viruses.6 t' \6 J! X+ N
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2.4 Centrifugation.
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2.5 Structural investigations of cells and virions./ R( P$ [% l1 n
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2.6 Electrophoretic techniques.* C( i* X3 w3 w6 p7 b* Z
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2.7 Detection of viruses and virus components.( I9 Z( |6 }' s9 I
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2.8 Infectivity assays.
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' x4 Z5 L/ X/ H2.9 Virus genetics.& J$ F  b5 K+ i- _
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3 Virus structure.% v& k9 j# L! b5 S/ z% [
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3.1 Introduction to virus structure.
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6 x' H: w7 X* T7 C% V3.2 Virus genomes.
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8 D, t, @! z0 u# Y3 x; q, Y3.3 Virus proteins.
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3.4 Capsids.
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2 n% f* K1 p/ s1 I0 Q1 y3.5 Virion membranes.& ^# ]2 G' J) P4 ?0 Y6 {' ^
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3.6 Occlusion bodies.
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* F! e# m; O- A  M( e( \( ^3.7 Other virion components.
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( s6 U; n1 J) e  X" [& x4 Virus transmission.* M" x+ ^: R* y' w. Q

$ r5 i% u$ V2 V4 P4.1 Introduction to virus transmission.5 R+ M! V, H. A( y+ g. s, N

! u( i8 C5 B: x: g( F4.2 Transmission of plant viruses., v, j" M6 j" o7 Z; }% s8 l

; e8 B# B& `& @4.3 Transmission of vertebrate viruses.
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! m: _( P& Q% q  q. F4.4 Transmission of invertebrate viruses.
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; b4 ~) W0 p% d6 \% L% U4 r: C& K4.5 Permissive cells.; c, L/ ~* c" n6 G) t- E5 T- _* S

& k! r5 V+ u9 ?7 K) D1 \5 Attachment and entry of viruses into cells.
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/ q( ~4 K  k" n1 P3 \# o; m5.1 Overview of virus replication.0 I( g2 M4 m0 t2 G
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5.2 Animal viruses.
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5.3 Bacteriophages.
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6 Transcription, translation and transport.4 t6 j( I' B) W, J5 g- ?, S& J
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6.1 Introduction to transcription, translation and transport.$ t. o$ R% z8 A# ?7 r

" H( W* w  Q- k4 M6.2 Transcription of virus genomes.
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/ e% Z+ I# |0 Q! n+ o9 R8 g6.3 Transcription in eukaryotes.2 Y- @3 R& t) J0 ^) ~# ]8 y

4 f8 q+ {) s! @7 E% U  D6.4 Translation in eukaryotes.
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- X/ _; a4 T: [' C% u$ K  i. e% C6.5 Transport in eukaryotic cells.0 V6 L7 H" c% Y" q, Z/ G

0 M/ r0 F) o9 k  V3 s* n6.6 Transcription and translation in bacteria.! W  v6 Y3 S" J7 w( D  j
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7 Virus genome replication.
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7.1 Overview of virus genome replication.
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7.2 Locations of virus genome replication in eukaryotic cells.
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3 |5 f) _$ _9 }  s' e6 G+ P7.3 Initiation of genome replication.1 P" ?1 T) Q! A' U) k" t9 q$ ?6 [3 m

1 O4 P* T+ U( B* s8 Z/ N0 u3 x7.4 Polymerases.
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7.5 DNA replication.
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: y5 U- t) Y7 V4 ]: a- s/ [7.6 Double-stranded RNA replication.: {+ G* R4 x9 }# ~& Q# S2 W2 F

1 r: K) A/ G* F1 \8 q; f7.7 Single-stranded RNA replication.5 l% W* F% R- ?9 z% y8 K
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7.8 Reverse transcription.
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8 Assembly and exit of virions from cells.; Q1 Z' n3 V! Q& O
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8.1 Introduction to assembly and exit of virions from cells.
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8.2 Nucleocapsid assembly.
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+ c+ \% B/ Q' O9 }. V0 y8.3 Formation of virion membranes.
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( b3 B8 ?9 t  \6 ], i" n5 ]/ m' n8.4 Virion exit from the infected cell.9 h1 z- ]; p# Z- n: I  g
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9 Outcomes of infection for the host./ U/ C; @5 |) k1 t
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9.1 Introduction to outcomes of infection for the host.
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9.2 Factors affecting outcomes of infection.7 B3 G  f8 b/ s: z
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9.3 Non-productive infections./ ~, S5 c  e7 E+ _- o( O0 b+ _
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9.4 Productive infections.+ _" q2 Q0 y" k' m
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10 Classification and nomenclature of viruses.# P$ H& T/ v% C% F1 d
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10.1 History of virus classification and nomenclature.6 ^5 ^9 v0 h- w) [: s3 ~$ F
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10.2 Modern virus classification and nomenclature.4 g* d0 O* f. b
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10.3 Baltimore classification of viruses.
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4 W8 @* A2 F: T. J0 P11 Herpesviruses (and other dsDNA viruses).
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: M2 I& l5 X& T: D+ B' _4 t11.1 Introduction to herpesviruses.3 a' J3 u, V' W* b! B# ?
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11.2 The human herpesviruses." O$ i) @. ~$ Q$ T0 E) r/ N

2 V7 B3 S( Z& V5 s. X9 d8 ?3 H& }11.3 The herpesvirus virion.9 H' Q. L: J7 i- N
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11.4 HSV-1 genome organization.
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0 @* |( Z: V4 N  _0 w  O$ a6 m& e! Z11.5 HSV-1 replication.: C3 ?* F' |" V) j4 P
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11.6 Latent herpesvirus infection.& s9 b, u4 V3 G/ l% R( i

6 U- Q. v: v$ Z6 L11.7 Other dsDNA viruses.
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12 Parvoviruses (and other ssDNA viruses).
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12.1 Introduction to parvoviruses.5 n' R! R0 L: D' V! }  M

3 G7 N: A  }# _) g12.2 Examples of parvoviruses.' V" \0 K/ t/ S: f- r( W3 V$ _

+ i" I( W4 |0 u& y) f12.3 Parvovirus virion.5 T: I  z8 M/ t* t1 s+ J2 U8 V
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12.4 Parvovirus replication.
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12.5 Other ssDNA viruses.
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  x, ~' d- B- T+ P. U+ l) `13 Reoviruses (and other dsRNA viruses).
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7 I5 N+ M/ w5 h& {9 f+ a: s13.1 Introduction to reoviruses.8 L1 J5 q* e  M4 N& j) S

$ g3 H7 \, G; ?- t3 c( {13.2 Rotavirus virion.
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13.3 Rotavirus replication.6 X7 P' b1 E/ U( _1 K
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13.4 Other dsRNA viruses.
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14 Picornaviruses (and other plus-strand RNA viruses).
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14.1 Introduction to picornaviruses.
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14.2 Some important picornaviruses.
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14.3 The picornavirus virion.
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% ^+ w; `9 U; E' p- f14.4 Picornavirus replication.
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14.5 Picornavirus recombination.3 t+ J6 [$ o: \  E. s

) l# D+ s5 q, T14.6 Picornavirus experimental systems
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14.7 Other plus-strand RNA viruses.% \: ?4 P# b( n6 v
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15 Rhabdoviruses (and other minus-strand RNA viruses).' q" Q5 ]* j1 L
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15.1 Introduction to rhabdoviruses.* _6 M7 R: v6 ]; |
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15.2 Some important rhabdoviruses.4 c$ v3 B0 b  D! o# g5 ]2 g
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15.3 The rhabdovirus virion and genome organization.. v+ D5 J5 D+ l: S* S/ A

) F$ m$ c5 r0 U- A15.4 Rhabdovirus replication.
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15.5 Other minus-strand RNA viruses.
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15.6 Viruses with ambisense genomes.
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# d: Z: E, P  A+ l15.7 Reverse genetics.
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16 Retroviruses.3 d8 j4 _8 D6 ~( i6 c

# r/ A* I' J: Z) ]2 |3 u, j16.1 Introduction to retroviruses.7 ?3 d8 F% o' U2 a! E5 o, y  g

5 x( w- Q! N4 X2 ?16.2 Retrovirus virion.+ I9 N* |0 D2 f0 ]2 ~- ~2 a
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16.3 Retrovirus replication.5 U8 j2 a* w1 Q0 k" y6 _
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16.4 Examples of retroviruses.1 Z0 B, z- R* A" R9 ^! `& R

1 ^& i; n- N* W+ B16.5 Retroviruses as gene vectors.2 R9 z7 h4 T, E) u0 _; h2 X7 w

' ]7 h7 w' k+ h0 o: t16.6 Endogenous retroviruses.
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" J* u: u$ Y0 g" u& G# Z17 Human immunodeficiency viruses.$ K! K6 g' s9 s( c- T6 X+ {, j
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17.1 Introduction to HIV.
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# Q: ]9 o0 N4 [0 t! j$ G; J17.2 HIV virion.6 e' K3 l6 ~/ h) t8 {

1 x3 x0 e: n/ r' R. e17.3 HIV genome.& T9 ^% q. u5 P! Q2 u) U, t

0 h- j8 L% ?- }$ p( J8 E. u: L3 ^4 U, c17.4 HIV-1 replication.3 Z$ O0 {1 |+ {- |" G
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17.5 HIV-1 variability.
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17.6 Progression of HIV infection.
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  D/ e5 d+ I' i- C: [  q17.7 Prevention of HIV transmission.% B+ ^8 G  S" G4 z; D
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18 Hepadnaviruses (and other reverse-transcribing DNA viruses)." X3 {* o' g/ m( d
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18.1 Introduction to hepadnaviruses.; {! _) N6 _% P
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18.2 Importance of HBV.
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18.3 HBV virion.1 f5 ?9 ~3 k6 }7 G

# V, f/ O' X5 s5 f2 [- G5 j18.4 Non-infectious particles.
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18.5 Soluble virus protein.( h1 i0 ]) n) g' U
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18.6 HBV genome.# v2 x, Z+ ?$ S
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18.7 HBV genetic groups.3 q  |  T7 m1 g3 F( d- k# V
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18.8 HBV replication cycle.
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9 X- e: h( n5 P6 N6 q9 r+ B9 i1 H/ G18.9 Prevention and treatment of HBV infection.
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+ l: f) O8 {) f18.10 Other reverse-transcribing DNA viruses.
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19 Bacterial viruses.
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- K0 T3 u+ e" D' F0 ?& z% C19.1 Introduction to bacterial viruses (bacteriophages.
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' R' z; Y3 \, z0 hRNA PHAGES.8 q& x7 E2 M, l+ A1 s: R
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19.2 Single-stranded RNA phages.* ~+ p8 E7 X& H( I* O
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19.3 Double-stranded RNA phages.
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: U. w3 _: F" Y/ P4 Z" s4 p# hDNA PHAGES.6 ?& i/ b/ P" G$ y$ Y

- C& I1 J  `, R$ @1 E) I19.4 Single-stranded DNA phages.
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19.5 Double-stranded DNA phages.
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20 Origins and evolution of viruses.
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& _# h3 [* l: n$ E: _/ N' V  L# N7 r21.1 Introduction to origins and evolution of viruses.6 L& Y* W# i3 [+ D2 h

# Y6 @4 V9 c3 \20.2 Origins of viruses.
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7 w* h1 P. @* \% N( N20.3 Evolution of viruses.6 l9 c1 q: v$ }1 A( P, m

; W' t; v4 e) A2 M21 Emerging viruses.: x  S3 E: O* h, K# ~4 N( f' ]

/ d3 A* [! }; e. C" x& {21.1 Introduction to emerging viruses
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21.2 Viruses in new host species6 ?* x* m& U. |$ x3 Q

/ g- O6 `9 a$ h6 a21.3 Viruses in new areas( e  c" e' s1 t. A8 a: \- f
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21.4 Viruses in new host species and in new areas
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21.5 New viruses
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9 ^# W& m8 `+ _3 K* e. |21.6 Recently discovered virus
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$ R+ {7 U+ i5 |1 ^& t) g/ h) H6 X5 T21.7 Re-emerging viruses. n9 Q, f+ U" U1 J: i4 g- ]

9 F  C* Z3 S3 k4 \- w21.8 Virus surveillance
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21.9 Dealing with outbreaks2 e% P( y0 t6 O9 N, ~! H

2 m0 V, C8 s+ \% z7 c8 C6 g% `22 Viruses and cancer
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& N6 _4 z2 b/ a22.1 Introduction to viruses and cancer
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/ O6 n$ y2 S% Y  ?8 E$ b6 S" r22.2 Papillomavirus-linked cancers% i5 o, s* @/ v

2 d  P7 ~4 N5 J* [0 v6 Z0 y22.3 Polyomavirus-linked cancers
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22.4 Epstein-Barr virus-linked cancers9 H9 }3 z3 {4 X" f
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22.5 Kaposi’s sarcoma" g" k- Z+ [# H; d; r: P( U  h

# l( e0 _5 N- |* ]% _6 o22.6 Adult T cell leukaemia
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! e- H2 {5 j2 ^! S9 \8 I22.7 Hepatocellular carcinoma: h  z% O! _5 C

4 r" V8 j6 |+ [! v# Q22.8 Virus-associated cancers in animals( {, O! q/ M5 n  m/ d1 ~
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22.9 Cell lines derived from virus-associated cancers.$ |4 B' ~- |# n2 I; U, b

1 f$ P* [4 X. S22.10 How do viruses cause cancer?* i- y; t7 w$ z  c) e
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22.11 Prevention of virus-induced cancers.
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23 Survival of infectivity.
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0 j7 @. m3 N6 Q23.1 Preservation of virus infectivity.2 r' s! I: `$ r' J& p' r; V

) x0 r1 f6 z: n23.2 Destruction of virus infectivity.
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23.3 Inactivation targets in virions." a( H# s! T6 ]- b: }+ o/ }% H4 m
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23.4 Inactivation kinetics.
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% g5 \2 y2 x# z" `  u9 T1 D23.5 Agents that inactivate virus infectivity.
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8 `' s" C1 Z; q. `2 M$ x9 a24 Virus vaccines.
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24.1 Introduction to virus vaccines.6 q6 O& z( t# u) E$ D! A5 p

+ t8 B4 E* L3 f/ j2 Q# N$ R24.2 Live attenuated virus vaccines.
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24.3 Inactivated virus vaccines.) M$ ]9 }7 d" W% B2 h

7 m' \; l; d* y& A24.4 Virion subunit vaccines.
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1 i( A! J. {; ^/ y! B) p" t7 U24.5 Live recombinant virus vaccines.
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24.6 Mass production of viruses for vaccines.
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24.7 Virus-like particles.3 H7 t# k  |& u! H

8 x! {: s3 Q: a! Q24.8 Synthetic peptide vaccines.; a1 i+ Z1 J- ~/ t7 G3 C; \

; K$ D2 a& g7 [5 c& H+ ?( o- J24.9 DNA vaccines.' l" T0 T& \, y9 |  r: Y6 z

6 Q7 Z$ y+ P0 L+ X; h24.10 Storage and transport of vaccines.9 `5 A- o% Z# H
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25 Anti-viral drugs.
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1 e3 T3 a( o1 S& [25.1 Introduction to anti-viral drugs.
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25.2 Development of anti-viral drugs.# t7 Y/ Q" _6 \  z$ j

/ \4 p5 [( S1 h7 L2 I0 C$ I25.3 Examples of anti-viral drugs.
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+ l; N6 _# X8 g" [3 l25.4 Drug resistance.
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" S# c$ J$ O8 z& b" G3 Q25.5 Anti-viral drug research.! Z4 k, r7 _' f% F4 H; [; S+ x% v
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26 Prions.
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( I7 {3 C" t5 Z26.1 Introduction to prions.
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26.2 Transmissible spongiform encephalopathies.
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% v6 y$ f$ ]8 \7 z2 g! u26.3 The nature of prions.2 |& Q: I' K: O4 j3 O: i0 r. r

+ z, m. p5 R0 h5 J! ^4 \7 h26.4 Prion diseases.
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26.5 Prion strains.) w$ X. X4 p' e
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26.6 Prion transmission.
5 {" H% i, N& c3 Z
: B. x0 N2 G0 B; T( M- R* K26.7 The protein-only hypothesis.
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6 @( L' S5 v2 N% ^! g+ m* ?% _/ [Learning outcomes.
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Sources of further information.) F$ ^! v- X0 ~3 Y- c3 q9 [

$ E0 A" [9 Q# R; a. Y  B. v1 gVirologists' vocabulary.
8 D- ]% c* A- S4 l% O$ b3 T0 q, o) L8 [& B8 s( ~
Index.

subenjinwo

好书！

yangpan521

回复 dahui 的帖子$ v: o: i8 K2 i9 }
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看看

chleiwu

学习

tait1

kankan

zorro

3qqq

zzc2211

好书，谢谢楼主分享

白色的风

谢谢楼主

susannajoke

好东西

stem_cell007

kankan