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In additional mating studies we have conducted (as yet unpublished)
* C9 f& M5 s% }6 C, M) u9 Xusing wild-type and HSF1 gene knockout mice,we have put individual mice through a 40-day continuous+ K& `0 F( l5 J
breeding assay following heat shock. Results from these
4 O8 J& c( Y- g# k0 kexperiments separate the histopathologic lesions in early$ y1 {% O* ?* X/ c+ H" U5 j
and late spermatogenic stages (i.e., apoptotic spermatocytes),
6 |' I* E3 L/ z8 ewhich are dependent on HSF1 and inducible HSP' i' p) O0 F1 f" W) o& g1 I" p- |7 Y
expression, from longer-term effects on reproductive performance
: ^4 q. x0 ^: ]5 N6 M+ P0 Z( brelating to spermatocyte-specific but stage-independent
- u a0 v2 N* y4 i+ I9 P: U6 [" d' q- ceffects.) R( n! E. e: l0 t- ~
来自文章Effects of Hyperthermia on Spermatogenesis, Apoptosis, Gene Expression,
# Z: @' t7 R7 d9 a( j4 |% w+ Uand Fertility in Adult Male Mice。2 D6 y* B, k% x$ Z7 F" |! p6 \* P
236页删划线部分
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0 e; R$ ^$ s- a* {4 g. d谢谢哦。 |
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