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In additional mating studies we have conducted (as yet unpublished)
% o: E8 f: J( B" \using wild-type and HSF1 gene knockout mice,we have put individual mice through a 40-day continuous# l1 {9 O+ [; u6 r
breeding assay following heat shock. Results from these
# }& \7 v# G$ L% Bexperiments separate the histopathologic lesions in early. t7 `! Y( f6 K( F5 H! s, G. r
and late spermatogenic stages (i.e., apoptotic spermatocytes),: a9 l8 M: V) o6 T
which are dependent on HSF1 and inducible HSP
7 Q+ n! V6 m# e2 [$ W4 U# {expression, from longer-term effects on reproductive performance
]' J1 G' o! crelating to spermatocyte-specific but stage-independent
& V5 O, ^$ |' B) I% J9 A" geffects.
% U. P7 L' P j" d( [ H来自文章Effects of Hyperthermia on Spermatogenesis, Apoptosis, Gene Expression,% O7 }& N9 y( I% X$ b* q2 a0 l
and Fertility in Adult Male Mice。) u! X$ B' _' J
236页删划线部分; a0 c6 S7 _/ c
& X( H: D6 c+ w' @1 o
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