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In additional mating studies we have conducted (as yet unpublished)
" v7 @! X2 ~0 C# `' Z/ h0 k h/ B9 _using wild-type and HSF1 gene knockout mice,we have put individual mice through a 40-day continuous
& d1 L: q' [! _! t' ]" P6 ]breeding assay following heat shock. Results from these
8 W7 y; R; B- g4 x6 p9 @1 }9 P( Oexperiments separate the histopathologic lesions in early
8 m! L3 x1 I, b- Q+ E& M4 iand late spermatogenic stages (i.e., apoptotic spermatocytes),
: }( ^% d' F- L7 r+ H( Twhich are dependent on HSF1 and inducible HSP8 i2 v8 _2 w$ k* g
expression, from longer-term effects on reproductive performance" l8 {) a2 t1 I/ t9 \
relating to spermatocyte-specific but stage-independent, ^% M: F$ Y7 ^( z( L
effects.$ ^( k4 g2 y% d
来自文章Effects of Hyperthermia on Spermatogenesis, Apoptosis, Gene Expression,
, J4 m4 k2 U; d) Z! Aand Fertility in Adult Male Mice。
- h! w4 C C2 X* h! H* ]" t9 I1 z236页删划线部分
1 _% j- l9 M, B: @* c0 O9 }7 d( ^+ L% \9 i* J6 N; [/ W
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