美科学家研究发现注射干细胞可延长寿命3倍

sunsong7

美科学家研究发现注射干细胞可延长寿命3倍(图)http://www.sina.com.cn  2012年01月06日 08:14  新浪科技微博
2 F; _5 H- F" q/ W9 ^  a& G9 b　　一项研究证实，注入一次干细胞，老鼠的寿命就会延长3倍。科学家认为，研究干细胞里的蛋白质可能是为人类提供“长生不老”注射剂的关键+ k& }3 q6 c% f3 ~9 [7 k% o
　　科学家表示，干细胞可以中断衰老过程，甚至是让寿命延长3倍。一项研究证实，注入一次干细胞，老鼠的寿命就会延长3倍3 d( k# C' M. ^. n; z
　　新浪科技讯 北京时间1月6日消息，科学家表示，干细胞可以中断衰老过程，甚至是让寿命延长3倍。一项研究证实，注入一次干细胞，老鼠的寿命就会延长3倍，而且会令老鼠长得更大更强壮。
. C2 c6 }9 Z5 s　　科学家认为，研究干细胞里的蛋白质可能是为人类提供“长生不老”注射剂的关键。美国匹兹堡大学的研究人员进行的进一步研究，将能帮助我们延迟衰老过程。这种效果甚至在实验室器皿里的细胞上就能看到，他们把年轻干细胞与过早衰老的细胞并排放置在一起。患者的衰老细胞在被放置到健康细胞一旁时，它们的功效会变得更好。美国研究人员在经过改良发生早衰(即已知的早衰症)的老鼠身上进行研究。人类也会出现早衰现象。
) x- f7 U4 Y5 z1 L- W　　研究人员从这些老鼠年轻健康时开始给它们注射干细胞，让它们的寿命延长到是那些早衰老鼠的3倍。他们的试验是第一项有关早衰受害者的干细胞研究。科学家发现这些老鼠体内的细胞与早衰老鼠的细胞存在差异，后者的细胞更小，而且比普通老鼠干细胞的再生速度更慢。然而，给17天大的小老鼠注射干细胞，结果发现它们的寿命明显延长，从平均只有21到28天延长到超过66天，比通常长3倍。4 L6 {* w8 P9 x: \/ K
　　为改良鼠注射干细胞后，它们生长的几乎与健康老鼠一样，而且大脑和肌肉里也长出新血管。科学家认为，这是因为健康干细胞能帮助纠正衰老老鼠细胞内出现的变异。该研究成果发表在《自然通讯》杂志上，论文作者劳拉-尼顿霍费尔博士说：“我们的试验显示，早衰老鼠从年轻、健康时开始注射干细胞，它们就会活得更健康、更长寿。这表明干细胞机能紊乱会导致衰老。”7 ]. M0 ]- _* O
　　尼顿霍费尔说：“随着早衰老鼠的年龄增加，它们的后腿肌肉会减少，并会出现驼背、颤抖、行动迟缓和笨拙等现象。受影响的老鼠如果在出现衰老第一迹象前注射一次干细胞，它们就会更像正常老鼠，而且长得几乎也像正常老鼠一样大。更进一步的研究显示，这些老鼠大脑和组织里还长出了新血管，即便没在这些组织里发现干细胞，情况也是如此。事实上干细胞在被注入到老鼠腹部后，它们并未转移到任何特定组织里。”$ h% H* ~6 J- H2 O" \7 s* `
　　“这让我们认为，健康细胞分泌因子创造的环境，有助于纠正土生土长的干细胞和衰老组织出现的机能紊乱。在一项培养皿试验过程中，我们把年轻干细胞放在早衰细胞一旁，但是二者并未接触，结果发现不健康细胞的功能显著提高。”(孝文); S/ @$ \: k" R$ u' u( |* `/ P& K( |8 v# b

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spchsq

楼主能不能提供一下原文或题目啊

sunsong7

spchsq 发表于 2012-1-8 10:57
1 m! O. X# X' S: V, @( ]6 V楼主能不能提供一下原文或题目啊

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Stem cells could hold key to 'stopping ageing' say scientists after trial triples mouse lifespan% m9 x; f7 x8 z$ _' O& T6 t* E6 \

• [size=1.4em]Lifespan tripled after injection of cells from young mice
• [size=1.4em]Injection made mice grow bigger and stronger
• [size=1.4em]Effect on ageing-disorder cells even works in lab dish# V+ l8 K) `% a8 }) Q
  
• [size=1.4em]Could hold key for injections that offer humans 'youthful vigor'
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By Rob Waugh0 \# N1 ^2 t$ r" T( Y
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Last updated at 8:24 AM on 4th January 2012
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An experiment proved that a single injection of stem cells could make mice live three times as long. Scientists think that studying the proteins within stem cells might hold the key to injections that offer a 'shot of youthful vigour' to human beings

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[size=1.2em]Stem cells can halt ageing - and even prolong lifespans up to three times, scientists say.
5 m+ e' X) M% k) F6 s[size=1.2em]An experiment proved that a single injection of stem cells could make mice live three times as long.( k7 x. n2 ?7 z; x! ^  n
[size=1.2em]The injection also made the mice grow bigger and stronger. 6 D1 i7 |. s0 c' I8 [
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[size=1.2em]Scientists think that studying the proteins within stem cells might hold the key to injections that offer a 'shot of youthful vigour' to human beings.4 c9 t/ I' \$ }; }; c  t5 J
[size=1.2em]The researchers, from the University of Pittsburgh,[size=1.2em]say further research could help us hold off the ageing process altogether.  ( i7 M( V5 h2 G9 z& \) f5 F- E& L

- b) ]5 r' t0 B9 v[size=1.2em]The effect was even visible on cells in a lab dish where young stem cells were placed next to prematurely ageing cells.   n+ \, _! Z  W% E3 a% L

4 X8 [. s2 B: ~# k' F[size=1.2em]The sick, ageing cells performed better after being placed next to the healthy ones. " Z+ ~, V4 C8 W5 L1 H2 L6 r
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[size=1.2em]The U.S. researchers conducted experiments on mice modified to age prematurely, a condition known as progeria. : y, E, Y( b9 P2 ?0 T  ]
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[size=1.2em]Progeria also occurs in humans.
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9 C- a. q/ z9 e# ]2 S[size=1.2em]Giving these mice shots of stem cells from young, healthy counterparts allowed them to live up to three times longer than those with progeria.  
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0 A  B5 q  B- k2 @! B, N" U[size=1.2em]Their experiment saw them first study the stem cells of the progeria sufferers." I1 G  f; t: ]
[size=1.2em]The scientists saw there was a difference between the cells in the mice with the ageing disorder - they had fewer, the ones they had regenerated less quickly than ordinary mouse stem cells.
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! u! X+ n1 P0 a/ Y1 [6 g, N1 W[size=1.2em]However, injecting stem cells into 17 day-old mice saw a huge increase in their lifespans - from an average of just 21-28 days to more than 66 days, three times longer than usual.
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) e; w, l8 o( X' I7 y- m" x6 |[size=1.2em]The modified mice given stem cell shots grew almost as large as their healthy counterparts and grew new blood vessels in their brains and muscles.  
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Stem cells can halt the signs of ageing - and even prolong lifespans up to three times, scientists say. An experiment proved that a single injection of stem cells could make mice live three times as long

2 Z9 n- x( r7 M( a[size=1.2em]'The mice were healthier and lived longer after an injection of stem cells from young, healthy animals,' said Dr Laura Niedernhofer2 Q+ t  \. X' B8 F

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1 g8 w4 e8 T/ U- ]2 H/ p[size=1.2em]Scientists think this is because the healthy stem cells helped correct abnormalities in the cells of the rapidly-ageing mice.    T  ~: z: |( t
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[size=1.2em]Study author Dr Laura Niedernhofer, whose findings were published in journal Nature Communications said: 'Our experiments showed that mice that have progeria, a disorder of premature aging, were healthier and lived longer after an injection of stem cells from young, healthy animals.'
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. J1 K! K2 K" {% o[size=1.2em]'That tells us that stem cell dysfunction is a cause of the changes we see with aging.'  She added: 'As the progeria mice age, they lose muscle mass in their hind limbs, hunch over, tremble, and move slowly and awkwardly.  
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# I7 K# d8 G( f% ?2 E6 l- W[size=1.2em]'Affected mice that got a shot of stem cells just before showing the first signs of ageing were more like normal mice, and they grew almost as large.': w4 `6 ~( f4 b% @+ i) h" M

: {. Q' w/ O! ^/ c' W, ~; Z[size=1.2em]'Closer examination showed new blood vessel growth in the brain and muscle, even though the stem/progenitor cells weren’t detected in those tissues.  ( s; y7 s, S0 S. A

/ [4 r* {! D! x; U[size=1.2em]'In fact, the cells didn’t migrate to any particular tissue after injection into the abdomen. '
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4 n( i0 v+ Y: D5 G[size=1.2em]“This leads us to think that healthy cells secrete factors to create an environment that help correct the dysfunction present in the native stem cell population and aged tissue." L' N% W. I; T7 s
[size=1.2em]'In a culture dish experiment, we put young stem cells close to, but not touching, progeria stem cells and the unhealthy cells functionally improved.' % ]) F8 P1 R" Y' Y' ]

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Read more: http://www.dailymail.co.uk/sciencetech/article-2081734/Stem-cells-hold-key-stopping-ageing-say-scientists-successful-mouse-trial.html#ixzz1iqRTmx7I