spchsq 发表于 2012-1-8 10:57  3 A) ]% D: x0 s/ {9 L' F9 g; N
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Stem cells could hold key to 'stopping ageing' say scientists after trial triples mouse lifespan
8 I+ ?8 G7 b* f- [size=1.4em]Lifespan tripled after injection of cells from young mice
- [size=1.4em]Injection made mice grow bigger and stronger
- [size=1.4em]Effect on ageing-disorder cells even works in lab dish
. f5 f* T! x$ }& C - [size=1.4em]Could hold key for injections that offer humans 'youthful vigor'# a; q( k, a: s1 t* D
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By Rob Waugh$ ]# P2 R4 u- b& z
8 |6 `0 ^; k9 E3 fLast updated at 8:24 AM on 4th January 2012
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, }( H# j2 S/ e( I An experiment proved that a single injection of stem cells could make mice live three times as long. Scientists think that studying the proteins within stem cells might hold the key to injections that offer a 'shot of youthful vigour' to human beings 1 @6 l+ S: Z+ ^% [& h. b3 c
[size=1.2em]Stem cells can halt ageing - and even prolong lifespans up to three times, scientists say.
( K0 U0 O3 l) E9 F! q) {[size=1.2em]An experiment proved that a single injection of stem cells could make mice live three times as long.
2 S3 a7 }- x3 x1 g) }[size=1.2em]The injection also made the mice grow bigger and stronger. 1 O" M3 G& X- M" b/ R2 B- z
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[size=1.2em]Scientists think that studying the proteins within stem cells might hold the key to injections that offer a 'shot of youthful vigour' to human beings.
& j4 m8 x& K8 @[size=1.2em]The researchers, from the University of Pittsburgh,[size=1.2em]say further research could help us hold off the ageing process altogether. ' n( a" c5 G" R+ w6 P+ P
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[size=1.2em]The effect was even visible on cells in a lab dish where young stem cells were placed next to prematurely ageing cells.
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3 ], g5 l6 R8 f7 z[size=1.2em]The sick, ageing cells performed better after being placed next to the healthy ones.
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[size=1.2em]The U.S. researchers conducted experiments on mice modified to age prematurely, a condition known as progeria.
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[size=1.2em]Progeria also occurs in humans.
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4 I$ K* m/ ~, @8 f4 u& a[size=1.2em]Giving these mice shots of stem cells from young, healthy counterparts allowed them to live up to three times longer than those with progeria.
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[size=1.2em]Their experiment saw them first study the stem cells of the progeria sufferers.
( q& S4 ]+ b+ Y. E[size=1.2em]The scientists saw there was a difference between the cells in the mice with the ageing disorder - they had fewer, the ones they had regenerated less quickly than ordinary mouse stem cells. & N: G% I, F5 `6 Q0 t5 y$ S
. E, b) ~. K+ j( _' T* B% l[size=1.2em]However, injecting stem cells into 17 day-old mice saw a huge increase in their lifespans - from an average of just 21-28 days to more than 66 days, three times longer than usual. 6 | ?% Q% j+ p2 C3 Z+ W) g. g. C
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[size=1.2em]The modified mice given stem cell shots grew almost as large as their healthy counterparts and grew new blood vessels in their brains and muscles.
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& C6 b" p; v: V: y9 b Stem cells can halt the signs of ageing - and even prolong lifespans up to three times, scientists say. An experiment proved that a single injection of stem cells could make mice live three times as long 2 t8 ?5 ~, P) s: h, L6 v5 M# u4 }
[size=1.2em]'The mice were healthier and lived longer after an injection of stem cells from young, healthy animals,' said Dr Laura Niedernhofer
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[size=1.2em]Scientists think this is because the healthy stem cells helped correct abnormalities in the cells of the rapidly-ageing mice. 2 V' Y& t$ E9 j; I1 O, [
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[size=1.2em]Study author Dr Laura Niedernhofer, whose findings were published in journal Nature Communications said: 'Our experiments showed that mice that have progeria, a disorder of premature aging, were healthier and lived longer after an injection of stem cells from young, healthy animals.'$ B _8 ^+ S! k$ m# o! m
, m4 F" q( C# q/ a! C8 t* K[size=1.2em]'That tells us that stem cell dysfunction is a cause of the changes we see with aging.' She added: 'As the progeria mice age, they lose muscle mass in their hind limbs, hunch over, tremble, and move slowly and awkwardly. D y8 ]9 F4 ]1 B5 o' b) Z' z% B4 G2 U
: P0 _; q% z. S u[size=1.2em]'Affected mice that got a shot of stem cells just before showing the first signs of ageing were more like normal mice, and they grew almost as large.'" d" p$ R' N% e, K
* C8 }/ t" t- }+ a6 u2 `1 z1 F[size=1.2em]'Closer examination showed new blood vessel growth in the brain and muscle, even though the stem/progenitor cells weren’t detected in those tissues. # ~5 @$ X; n, o9 t9 t% w: i
: j. w0 ~( K3 o: V' t. {[size=1.2em]'In fact, the cells didn’t migrate to any particular tissue after injection into the abdomen. '* E, E. j0 M8 s2 K! s
( ]9 G! C/ D- R1 S l1 I[size=1.2em]“This leads us to think that healthy cells secrete factors to create an environment that help correct the dysfunction present in the native stem cell population and aged tissue.
" F5 G7 s8 O" p, W. [0 s8 |( k Z[size=1.2em]'In a culture dish experiment, we put young stem cells close to, but not touching, progeria stem cells and the unhealthy cells functionally improved.' ! z q$ k! P& R- a4 @2 y6 d
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Read more: http://www.dailymail.co.uk/sciencetech/article-2081734/Stem-cells-hold-key-stopping-ageing-say-scientists-successful-mouse-trial.html#ixzz1iqRTmx7I |
发表于 2012-1-7 22:36
一项研究证实，注入一次干细胞，老鼠的寿命就会延长3倍。科学家认为，研究干细胞里的蛋白质可能是为人类提供“长生不老”注射剂的关键( x8 t& W7 I& |8 k5 k8 }4 ~
科学家表示，干细胞可以中断衰老过程，甚至是让寿命延长3倍。一项研究证实，注入一次干细胞，老鼠的寿命就会延长3倍5 Z' D/ E. L8 K* }5 f, `
发表于 2012-1-8 10:57
