spchsq 发表于 2012-1-8 10:57  G7 k7 u$ R: z! E
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8 r$ ?: R: q0 mStem cells could hold key to 'stopping ageing' say scientists after trial triples mouse lifespan2 h* b% L- a8 D
- [size=1.4em]Lifespan tripled after injection of cells from young mice
- [size=1.4em]Injection made mice grow bigger and stronger
- [size=1.4em]Effect on ageing-disorder cells even works in lab dish
% H: A$ E$ x) o. Y/ T0 _ - [size=1.4em]Could hold key for injections that offer humans 'youthful vigor'5 }, Z/ F) A8 R( h
: D# Z# ^9 _) Q j# ]( uBy Rob Waugh
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: k( E d3 ~- T( j. e# J( W; E4 aLast updated at 8:24 AM on 4th January 2012
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 An experiment proved that a single injection of stem cells could make mice live three times as long. Scientists think that studying the proteins within stem cells might hold the key to injections that offer a 'shot of youthful vigour' to human beings ; d' M$ k; I' z5 R, y" V
[size=1.2em]Stem cells can halt ageing - and even prolong lifespans up to three times, scientists say.; W" e# F' n1 V
[size=1.2em]An experiment proved that a single injection of stem cells could make mice live three times as long.% r4 E2 H. P+ K% G, t( e o
[size=1.2em]The injection also made the mice grow bigger and stronger.
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- _( ^. i# a, r R0 |2 Y[size=1.2em]Scientists think that studying the proteins within stem cells might hold the key to injections that offer a 'shot of youthful vigour' to human beings.
4 a8 s+ w9 \5 W4 ? p$ o3 u' t[size=1.2em]The researchers, from the University of Pittsburgh,[size=1.2em]say further research could help us hold off the ageing process altogether.
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[size=1.2em]The effect was even visible on cells in a lab dish where young stem cells were placed next to prematurely ageing cells.
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[size=1.2em]The sick, ageing cells performed better after being placed next to the healthy ones. & W( H' a6 d' N/ U( T6 q& k- z
. [6 I$ v, K1 s S# u! F+ \[size=1.2em]The U.S. researchers conducted experiments on mice modified to age prematurely, a condition known as progeria.
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[size=1.2em]Progeria also occurs in humans.
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[size=1.2em]Giving these mice shots of stem cells from young, healthy counterparts allowed them to live up to three times longer than those with progeria.
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[size=1.2em]Their experiment saw them first study the stem cells of the progeria sufferers.
5 R+ g5 O) \) o5 O/ C I[size=1.2em]The scientists saw there was a difference between the cells in the mice with the ageing disorder - they had fewer, the ones they had regenerated less quickly than ordinary mouse stem cells. % i M9 \" F3 `
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[size=1.2em]However, injecting stem cells into 17 day-old mice saw a huge increase in their lifespans - from an average of just 21-28 days to more than 66 days, three times longer than usual.
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+ Y+ k' W4 S/ S9 o* |[size=1.2em]The modified mice given stem cell shots grew almost as large as their healthy counterparts and grew new blood vessels in their brains and muscles.
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 Stem cells can halt the signs of ageing - and even prolong lifespans up to three times, scientists say. An experiment proved that a single injection of stem cells could make mice live three times as long
9 q. n& a$ p" m9 ]$ f" \7 A: R9 X[size=1.2em]'The mice were healthier and lived longer after an injection of stem cells from young, healthy animals,' said Dr Laura Niedernhofer
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+ G$ a, G' A, e[size=1.2em]Scientists think this is because the healthy stem cells helped correct abnormalities in the cells of the rapidly-ageing mice. 7 ^4 e8 L4 @, C8 {2 E
+ D2 s+ Z. s# p4 \ {* S s' I# i[size=1.2em]Study author Dr Laura Niedernhofer, whose findings were published in journal Nature Communications said: 'Our experiments showed that mice that have progeria, a disorder of premature aging, were healthier and lived longer after an injection of stem cells from young, healthy animals.'
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0 y; H( b6 [1 J9 x: ^9 T' \; {[size=1.2em]'That tells us that stem cell dysfunction is a cause of the changes we see with aging.' She added: 'As the progeria mice age, they lose muscle mass in their hind limbs, hunch over, tremble, and move slowly and awkwardly.
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[size=1.2em]'Affected mice that got a shot of stem cells just before showing the first signs of ageing were more like normal mice, and they grew almost as large.'4 _; U. ]+ S+ }# j- Q
% y/ N( l3 Y" Q% v7 Z6 C; O[size=1.2em]'Closer examination showed new blood vessel growth in the brain and muscle, even though the stem/progenitor cells weren’t detected in those tissues. . A$ d" _- e8 m3 I5 W! E% Y' S
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[size=1.2em]'In fact, the cells didn’t migrate to any particular tissue after injection into the abdomen. '
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5 p3 p+ b8 J, Y3 P[size=1.2em]“This leads us to think that healthy cells secrete factors to create an environment that help correct the dysfunction present in the native stem cell population and aged tissue.+ L/ D1 I0 n; ^8 G
[size=1.2em]'In a culture dish experiment, we put young stem cells close to, but not touching, progeria stem cells and the unhealthy cells functionally improved.'
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Read more: http://www.dailymail.co.uk/sciencetech/article-2081734/Stem-cells-hold-key-stopping-ageing-say-scientists-successful-mouse-trial.html#ixzz1iqRTmx7I |
发表于 2012-1-7 22:36
一项研究证实，注入一次干细胞，老鼠的寿命就会延长3倍。科学家认为，研究干细胞里的蛋白质可能是为人类提供“长生不老”注射剂的关键5 V: n+ p# U% E; G
科学家表示，干细胞可以中断衰老过程，甚至是让寿命延长3倍。一项研究证实，注入一次干细胞，老鼠的寿命就会延长3倍$ F& ^9 {( w( S. V- [) z
发表于 2012-1-8 10:57
