spchsq 发表于 2012-1-8 10:57  . i/ T( X" Z, c- q+ G
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1 |1 F3 L: w c& _ tStem cells could hold key to 'stopping ageing' say scientists after trial triples mouse lifespan
. ]/ ^, b3 \( n/ h- [size=1.4em]Lifespan tripled after injection of cells from young mice
- [size=1.4em]Injection made mice grow bigger and stronger
- [size=1.4em]Effect on ageing-disorder cells even works in lab dish
( a4 L9 ^6 y* z' |$ z9 @ - [size=1.4em]Could hold key for injections that offer humans 'youthful vigor'
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+ H' a1 o1 R9 G2 C2 G/ T" \By Rob Waugh- |! }1 j6 v2 `: p
9 V' r( y* N( x f5 N) oLast updated at 8:24 AM on 4th January 2012. e' x% |# p* p6 R' a; m
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 An experiment proved that a single injection of stem cells could make mice live three times as long. Scientists think that studying the proteins within stem cells might hold the key to injections that offer a 'shot of youthful vigour' to human beings 4 C: S4 g3 m# N' ~: N2 A
[size=1.2em]Stem cells can halt ageing - and even prolong lifespans up to three times, scientists say.
- F% N+ r( p" a/ b# ~& f% j0 z' w[size=1.2em]An experiment proved that a single injection of stem cells could make mice live three times as long.# s3 `$ P" L' g* N1 l5 X
[size=1.2em]The injection also made the mice grow bigger and stronger.
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[size=1.2em]Scientists think that studying the proteins within stem cells might hold the key to injections that offer a 'shot of youthful vigour' to human beings.
! R+ Y# C+ ]: Z6 {1 t& r8 A; p1 \: |[size=1.2em]The researchers, from the University of Pittsburgh,[size=1.2em]say further research could help us hold off the ageing process altogether. - _9 p* }* D2 j, \
: _, `9 ~4 [ w1 e6 {( H. M1 ^[size=1.2em]The effect was even visible on cells in a lab dish where young stem cells were placed next to prematurely ageing cells.
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[size=1.2em]The sick, ageing cells performed better after being placed next to the healthy ones.
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0 T% C% a0 F R* x' M[size=1.2em]The U.S. researchers conducted experiments on mice modified to age prematurely, a condition known as progeria.
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[size=1.2em]Progeria also occurs in humans.
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+ J8 `! W0 k6 L, k( A[size=1.2em]Giving these mice shots of stem cells from young, healthy counterparts allowed them to live up to three times longer than those with progeria. 4 k3 Q5 ~0 t5 O7 I" E% t8 s9 \
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[size=1.2em]Their experiment saw them first study the stem cells of the progeria sufferers.7 B/ l! B# ]# f6 s5 J! O3 f
[size=1.2em]The scientists saw there was a difference between the cells in the mice with the ageing disorder - they had fewer, the ones they had regenerated less quickly than ordinary mouse stem cells. , F# \0 G2 w/ k7 I' r6 K
2 P& E) q# d n1 r4 K& p4 ^[size=1.2em]However, injecting stem cells into 17 day-old mice saw a huge increase in their lifespans - from an average of just 21-28 days to more than 66 days, three times longer than usual.
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) Z6 J7 u8 f; c3 K$ x[size=1.2em]The modified mice given stem cell shots grew almost as large as their healthy counterparts and grew new blood vessels in their brains and muscles.
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: J1 O2 w' m# h/ Z! b/ H Stem cells can halt the signs of ageing - and even prolong lifespans up to three times, scientists say. An experiment proved that a single injection of stem cells could make mice live three times as long
) h' a. b& C1 g- }' ]$ h[size=1.2em]'The mice were healthier and lived longer after an injection of stem cells from young, healthy animals,' said Dr Laura Niedernhofer
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[size=1.2em]Scientists think this is because the healthy stem cells helped correct abnormalities in the cells of the rapidly-ageing mice. / ]- P& A2 d' H
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[size=1.2em]Study author Dr Laura Niedernhofer, whose findings were published in journal Nature Communications said: 'Our experiments showed that mice that have progeria, a disorder of premature aging, were healthier and lived longer after an injection of stem cells from young, healthy animals.'3 @; v5 e8 v! E. g
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[size=1.2em]'That tells us that stem cell dysfunction is a cause of the changes we see with aging.' She added: 'As the progeria mice age, they lose muscle mass in their hind limbs, hunch over, tremble, and move slowly and awkwardly.
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+ H q0 m) b; S[size=1.2em]'Affected mice that got a shot of stem cells just before showing the first signs of ageing were more like normal mice, and they grew almost as large.'" F+ I! }3 E& j2 D
2 `7 l8 E( O- h- M7 ]. d[size=1.2em]'Closer examination showed new blood vessel growth in the brain and muscle, even though the stem/progenitor cells weren’t detected in those tissues. 1 P7 d6 L) ?3 U2 j
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[size=1.2em]'In fact, the cells didn’t migrate to any particular tissue after injection into the abdomen. '
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[size=1.2em]“This leads us to think that healthy cells secrete factors to create an environment that help correct the dysfunction present in the native stem cell population and aged tissue.
% \. O' K: i5 F0 ][size=1.2em]'In a culture dish experiment, we put young stem cells close to, but not touching, progeria stem cells and the unhealthy cells functionally improved.'
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9 s C$ l1 [! p0 i* sRead more: http://www.dailymail.co.uk/sciencetech/article-2081734/Stem-cells-hold-key-stopping-ageing-say-scientists-successful-mouse-trial.html#ixzz1iqRTmx7I |
发表于 2012-1-7 22:36
一项研究证实，注入一次干细胞，老鼠的寿命就会延长3倍。科学家认为，研究干细胞里的蛋白质可能是为人类提供“长生不老”注射剂的关键
科学家表示，干细胞可以中断衰老过程，甚至是让寿命延长3倍。一项研究证实，注入一次干细胞，老鼠的寿命就会延长3倍1 B' S2 q' ^- v- a2 N2 n
发表于 2012-1-8 10:57
