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7 Z# ^2 A! ^: i. ?! R1 uVolume 149, Issue 3
6 C/ M5 N3 U9 ]On the cover: The combined activity of neurons in the brain generates 0 J; J- C* D+ }1 \& ?3 X
oscillatory rhythms, or “brain waves,” that can be detected by ; l$ R7 d$ Q F! q
electroencephalographic recordings. Verret et al. (pp.708–721) found that these
p- Y7 X: P" {( v" o' Hbrain waves, which are represented on the cover by an undulating pattern, are
8 e4 ^; g1 O7 paltered in mouse model of Alzheimer's disease (AD), and the changes are linked
- q3 Y6 W0 h+ ]9 Vto reduced levels of a voltage-gated sodium channel subunit, Nav1.1. Restoring
: X1 r* t; i; x- O, B0 }Nav1.1 levels specifically in inhibitory interneurons improves oscillatory 2 q( ~) ?4 a3 I: E3 w3 w- V9 X
rhythms and memory in AD mice, offering a new therapeutic approach for . w; g# h g1 N. o/ \ M
potentially treating cognitive disorders. The image was created by Arantxa ' P0 `4 ]: \6 g9 a; I
Esteban (original paintings “Ondas 1” and “Ondas 2”) and Jorge J. Palop 4 K8 s f4 Y8 C# c8 [
(electronic recreation).9 c4 ^: X: U$ p! W$ r
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