《细胞》[Cell]12年4月27日出版pdf全文

nero1981

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Volume 149, Issue 3$ {" v" M, |2 s4 b2 r- b+ F
On the cover: The combined activity of neurons in the brain generates 2 E3 c+ p' g  G( P: F3 |" g
oscillatory rhythms, or “brain waves,” that can be detected by & ]5 ^, u# e  v; @
electroencephalographic recordings. Verret et al. (pp.708–721) found that these
! G8 I0 S0 U2 H" f) X$ W# Fbrain waves, which are represented on the cover by an undulating pattern, are
( d8 y' }) Z6 P; s6 A0 w- qaltered in mouse model of Alzheimer's disease (AD), and the changes are linked , q: d  w0 R0 z' c4 n5 m( N
to reduced levels of a voltage-gated sodium channel subunit, Nav1.1. Restoring
5 O6 e) c& z2 r& q* vNav1.1 levels specifically in inhibitory interneurons improves oscillatory 7 a0 N- [! X% y( G6 `& c& |
rhythms and memory in AD mice, offering a new therapeutic approach for : x2 \+ U3 y1 [, E8 f3 Y$ U* d  c
potentially treating cognitive disorders. The image was created by Arantxa
7 n/ F8 K" R, ]/ `Esteban (original paintings “Ondas 1” and “Ondas 2”) and Jorge J. Palop
0 ~% e, z% X2 b/ d' F' a( k" N(electronic recreation).5 I3 V. I! ^, b" a: [) G! l7 P) X9 K. C
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menghy

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xiaoheilong

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eley

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cytobiology

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zorro

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191225092

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