《细胞》[Cell]12年4月27日出版pdf全文

nero1981

- ?; Q- {5 {, |4 `: UVolume 149, Issue 31 n1 s6 h/ o: ]% [1 _+ U- v
On the cover: The combined activity of neurons in the brain generates 2 }4 E+ J5 s; {' E" ^3 G
oscillatory rhythms, or “brain waves,” that can be detected by
/ P* }+ x1 b, I" f9 Jelectroencephalographic recordings. Verret et al. (pp.708–721) found that these
1 j6 |" V: w& m: xbrain waves, which are represented on the cover by an undulating pattern, are / D0 `! ?7 D: h" k
altered in mouse model of Alzheimer's disease (AD), and the changes are linked
2 I4 E- P6 P# x: o' u+ K: G4 f' p% \to reduced levels of a voltage-gated sodium channel subunit, Nav1.1. Restoring
/ c/ S# x* n6 mNav1.1 levels specifically in inhibitory interneurons improves oscillatory ) [( t) b3 c' R) q7 }/ q
rhythms and memory in AD mice, offering a new therapeutic approach for   [3 j! B8 e4 ?# `! n8 f
potentially treating cognitive disorders. The image was created by Arantxa
( ?" H8 M" Z1 LEsteban (original paintings “Ondas 1” and “Ondas 2”) and Jorge J. Palop ( I$ x1 S, N( Q7 d
(electronic recreation).
4 {) ]9 ?3 Q* `' c[hide][/hide]

menghy

谢谢分享！！

xiaoheilong

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不倒翁

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不倒翁

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eley

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cytobiology

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zorro

回复 cytobiology 的帖子. m" d: k' o4 A5 X  \8 m0 m
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markllq

谢谢
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191225092

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