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Volume 149, Issue 3" |& u8 ?& ^: H% r7 ^( M
On the cover: The combined activity of neurons in the brain generates : J) e- Q( Y8 I& F# c
oscillatory rhythms, or “brain waves,” that can be detected by ) I: n& v, O" {5 ?/ |( J$ k5 ?
electroencephalographic recordings. Verret et al. (pp.708–721) found that these + Q3 g# i5 L: R
brain waves, which are represented on the cover by an undulating pattern, are 1 r& a8 ~0 ^. ^0 r' X' F
altered in mouse model of Alzheimer's disease (AD), and the changes are linked . c5 u1 o8 a9 L0 C2 r" M. w! w
to reduced levels of a voltage-gated sodium channel subunit, Nav1.1. Restoring 6 m6 O: T t( Z# J2 }4 C8 H: s F
Nav1.1 levels specifically in inhibitory interneurons improves oscillatory 6 x6 u( z G8 e+ u" C5 n
rhythms and memory in AD mice, offering a new therapeutic approach for
; \! ~9 A" k! V. V( O \. @5 Z$ Gpotentially treating cognitive disorders. The image was created by Arantxa
" O! j2 U' P& NEsteban (original paintings “Ondas 1” and “Ondas 2”) and Jorge J. Palop - R t: @) ^/ A6 X5 N4 p
(electronic recreation).
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