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& r* P1 {) ]; M6 E- WVolume 149, Issue 3+ Q& r% k& c1 m& w
On the cover: The combined activity of neurons in the brain generates 3 l1 _" o. U8 D! K" H0 {3 Q
oscillatory rhythms, or “brain waves,” that can be detected by
f7 ~" R9 d% P1 H' belectroencephalographic recordings. Verret et al. (pp.708–721) found that these - C9 w- i5 Q8 L
brain waves, which are represented on the cover by an undulating pattern, are 3 s+ X! {* F6 O4 D! t" L- Y
altered in mouse model of Alzheimer's disease (AD), and the changes are linked 7 z( n0 q$ o3 s" Y
to reduced levels of a voltage-gated sodium channel subunit, Nav1.1. Restoring
- \, D. V' A! `$ U7 @- C! v% VNav1.1 levels specifically in inhibitory interneurons improves oscillatory ; ?' D {) S* S2 S& v W' X6 O2 y
rhythms and memory in AD mice, offering a new therapeutic approach for # s7 B. T' l/ Y# Z
potentially treating cognitive disorders. The image was created by Arantxa 3 F8 ]# Y0 d3 ?: u" X h' a) c
Esteban (original paintings “Ondas 1” and “Ondas 2”) and Jorge J. Palop + N0 w1 D& {. y' m4 T% @
(electronic recreation).
3 ^: b7 T8 G* w' b' B- }[hide][/hide] |
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