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) R; @# N; A" D! k3 a2 EVolume 149, Issue 3) b1 n& F, d' \, ?, g/ G B
On the cover: The combined activity of neurons in the brain generates 5 v/ }2 i; a" M0 i
oscillatory rhythms, or “brain waves,” that can be detected by
# ]! L3 j& V% C3 y8 Welectroencephalographic recordings. Verret et al. (pp.708–721) found that these
& m3 p$ _; u. V" \- t @brain waves, which are represented on the cover by an undulating pattern, are
& k2 }2 `( F' Naltered in mouse model of Alzheimer's disease (AD), and the changes are linked ; q; J. _6 ?7 K
to reduced levels of a voltage-gated sodium channel subunit, Nav1.1. Restoring " w8 q! U: ~3 n" r1 H
Nav1.1 levels specifically in inhibitory interneurons improves oscillatory
7 I; k" s( W! o6 Krhythms and memory in AD mice, offering a new therapeutic approach for 0 K7 Z: A2 K4 X7 ?) E$ a0 W
potentially treating cognitive disorders. The image was created by Arantxa ! B M' d4 q/ s$ k7 T# K
Esteban (original paintings “Ondas 1” and “Ondas 2”) and Jorge J. Palop " ]7 }) D$ z9 o
(electronic recreation).
& `: z A' K( W f2 D' r1 J( P[hide][/hide] |
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