《细胞》[Cell]12年4月27日出版pdf全文

nero1981

: ~% S! Y* g' _Volume 149, Issue 3
: X3 s$ _3 Q- g& rOn the cover: The combined activity of neurons in the brain generates
% e6 W8 E; ?7 c; aoscillatory rhythms, or “brain waves,” that can be detected by
' S) S: K, X: m7 O9 aelectroencephalographic recordings. Verret et al. (pp.708–721) found that these
! S) P- L, X4 `- Q$ [) Hbrain waves, which are represented on the cover by an undulating pattern, are
( x! B( {* {4 l* Naltered in mouse model of Alzheimer's disease (AD), and the changes are linked . E8 Z1 C4 a. t. m1 J8 `: J) g
to reduced levels of a voltage-gated sodium channel subunit, Nav1.1. Restoring
7 P( G+ `4 G9 u' ~1 ~+ b: tNav1.1 levels specifically in inhibitory interneurons improves oscillatory
: x: g- J: a* ^0 H# |  |4 nrhythms and memory in AD mice, offering a new therapeutic approach for 8 X7 _: t& t# j& y4 o$ I
potentially treating cognitive disorders. The image was created by Arantxa
% O$ E6 }4 M; I1 v" h3 ~Esteban (original paintings “Ondas 1” and “Ondas 2”) and Jorge J. Palop
0 x- }# G( w4 E" W' H(electronic recreation).
( b* a" H1 w* U5 |1 d: Z[hide][/hide]

menghy

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xiaoheilong

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不倒翁

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eley

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cytobiology

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markllq

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191225092

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