《细胞》[Cell]12年4月27日出版pdf全文

nero1981

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Volume 149, Issue 3
7 `3 |' @- W3 Y( L+ i" [6 WOn the cover: The combined activity of neurons in the brain generates
7 l. {+ X/ O# l: Q3 Voscillatory rhythms, or “brain waves,” that can be detected by " K& j6 Y# @1 @9 V* f! N/ y
electroencephalographic recordings. Verret et al. (pp.708–721) found that these , p% Q" |6 ^5 @" O6 a" t3 `
brain waves, which are represented on the cover by an undulating pattern, are
/ O" C( U8 ~; _( y" J' M* a2 D# saltered in mouse model of Alzheimer's disease (AD), and the changes are linked
: l! _/ h' c9 u! Z9 o" `2 sto reduced levels of a voltage-gated sodium channel subunit, Nav1.1. Restoring
5 I' o/ i, H  f7 e  ^6 }" {Nav1.1 levels specifically in inhibitory interneurons improves oscillatory
: T5 f4 ~6 N9 Y; vrhythms and memory in AD mice, offering a new therapeutic approach for : j( L) [- B. U, p& D# h9 S) R
potentially treating cognitive disorders. The image was created by Arantxa
! ?9 k6 S/ W4 C7 e, UEsteban (original paintings “Ondas 1” and “Ondas 2”) and Jorge J. Palop   P& N# [6 O: \( |6 w
(electronic recreation).) L: T( w6 v. D- F& `' j
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menghy

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xiaoheilong

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eley

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cytobiology

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markllq

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191225092

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