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- t3 I. z' g( ~Volume 149, Issue 3
$ \1 S8 I1 V2 LOn the cover: The combined activity of neurons in the brain generates 1 k' D" z( @3 K! b R
oscillatory rhythms, or “brain waves,” that can be detected by
( j, U! `& H% ^* f- d b3 j8 H/ {electroencephalographic recordings. Verret et al. (pp.708–721) found that these
6 D" \/ }) H$ T$ j9 Zbrain waves, which are represented on the cover by an undulating pattern, are 2 u! S. B+ ?1 d) O
altered in mouse model of Alzheimer's disease (AD), and the changes are linked 0 M$ s: {2 L+ `& k
to reduced levels of a voltage-gated sodium channel subunit, Nav1.1. Restoring : u" f0 k+ E/ q
Nav1.1 levels specifically in inhibitory interneurons improves oscillatory " H0 `% g6 h3 c0 ^9 P+ t
rhythms and memory in AD mice, offering a new therapeutic approach for u! W X9 E2 c
potentially treating cognitive disorders. The image was created by Arantxa # L9 y8 k6 }& O0 T R& f: z: u
Esteban (original paintings “Ondas 1” and “Ondas 2”) and Jorge J. Palop " B. D. v. |( |* r
(electronic recreation).1 {8 V m5 f5 D. d" F2 U- R, y
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