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. O6 i; \, @) a* `: ]1 ]+ mVolume 149, Issue 3) W/ h! h/ I* _8 J/ [- [0 k. }) N( }
On the cover: The combined activity of neurons in the brain generates
, z- ~ w) q0 }oscillatory rhythms, or “brain waves,” that can be detected by
3 T7 G6 j8 W# g9 ?2 L% K: s" d Felectroencephalographic recordings. Verret et al. (pp.708–721) found that these & V6 _2 n' a/ N1 d' V
brain waves, which are represented on the cover by an undulating pattern, are
7 @! H. t" `/ A# ]altered in mouse model of Alzheimer's disease (AD), and the changes are linked
* f# N3 _, C" P* mto reduced levels of a voltage-gated sodium channel subunit, Nav1.1. Restoring : D3 W2 m+ b4 a* {2 ?
Nav1.1 levels specifically in inhibitory interneurons improves oscillatory
$ M" l6 G+ R: o& P" n. H& Rrhythms and memory in AD mice, offering a new therapeutic approach for n! H3 K1 z) L3 \) L
potentially treating cognitive disorders. The image was created by Arantxa
7 T' `& C5 Z: P5 Z4 D9 ]8 sEsteban (original paintings “Ondas 1” and “Ondas 2”) and Jorge J. Palop
' ^. a( F# j8 @4 |(electronic recreation).7 k& k" S" U1 r1 D* g( { m
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