《细胞》[Cell]12年4月27日出版pdf全文

nero1981

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Volume 149, Issue 3
& j/ K* J: l1 L$ kOn the cover: The combined activity of neurons in the brain generates
7 d! R6 a- l( ^: x! r& A8 ioscillatory rhythms, or “brain waves,” that can be detected by 0 F6 S% c* l4 J8 `6 e* e
electroencephalographic recordings. Verret et al. (pp.708–721) found that these
' r% R2 b" _' \9 F# A2 sbrain waves, which are represented on the cover by an undulating pattern, are : T- d1 z8 }2 Q/ O' V- c
altered in mouse model of Alzheimer's disease (AD), and the changes are linked
3 P& \, z3 {7 l3 }  Xto reduced levels of a voltage-gated sodium channel subunit, Nav1.1. Restoring
7 `) C& Z+ m; w* SNav1.1 levels specifically in inhibitory interneurons improves oscillatory
1 P) n9 W! w6 O0 qrhythms and memory in AD mice, offering a new therapeutic approach for 4 L2 t0 p6 g% B  o
potentially treating cognitive disorders. The image was created by Arantxa
  g5 f0 h! |, j4 y3 qEsteban (original paintings “Ondas 1” and “Ondas 2”) and Jorge J. Palop % Y/ u$ U  s: t9 s6 ^% Y: r/ A
(electronic recreation).
* _& x/ ~* L& n4 C# K# x[hide][/hide]

menghy

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cytobiology

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markllq

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191225092

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