《细胞》[Cell]12年4月27日出版pdf全文

nero1981

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Volume 149, Issue 3' P/ N3 E# E* c$ m6 ?) |
On the cover: The combined activity of neurons in the brain generates 6 Z! ]5 U% N& x1 W
oscillatory rhythms, or “brain waves,” that can be detected by ; R7 n. b" {! t
electroencephalographic recordings. Verret et al. (pp.708–721) found that these
% c) J" W" o4 E' r* a. lbrain waves, which are represented on the cover by an undulating pattern, are & M% C+ ~0 A7 A' N. h8 M4 s; i0 ?  J
altered in mouse model of Alzheimer's disease (AD), and the changes are linked
9 b; |2 R* d/ X8 Wto reduced levels of a voltage-gated sodium channel subunit, Nav1.1. Restoring ) J% Z$ A& k( j  d8 }3 z) \3 X
Nav1.1 levels specifically in inhibitory interneurons improves oscillatory ; P& A1 Y; B- v% T* V; g! N
rhythms and memory in AD mice, offering a new therapeutic approach for
, G4 p0 O7 L3 D6 }. w7 Jpotentially treating cognitive disorders. The image was created by Arantxa 7 H2 q8 d. x( N7 w4 h
Esteban (original paintings “Ondas 1” and “Ondas 2”) and Jorge J. Palop * i- L3 s  @* H* i0 w7 r: _+ R/ Y
(electronic recreation).8 N: u, `$ ]% G9 V4 `- h- v
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menghy

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xiaoheilong

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不倒翁

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eley

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cytobiology

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zorro

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markllq

谢谢
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191225092

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