《细胞》[Cell]12年4月27日出版pdf全文

nero1981

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Volume 149, Issue 3' g3 c! p; u+ o" v" r0 Q
On the cover: The combined activity of neurons in the brain generates
- N' [) t" Z: V% X8 ^. q' b0 x& xoscillatory rhythms, or “brain waves,” that can be detected by ! j) H% u/ [8 \% C0 L6 e' b) O
electroencephalographic recordings. Verret et al. (pp.708–721) found that these
6 V1 R: t4 X4 l" V& K5 n' E1 rbrain waves, which are represented on the cover by an undulating pattern, are 3 Q8 L1 o% R& S, m1 W2 m( [
altered in mouse model of Alzheimer's disease (AD), and the changes are linked " T2 A3 r  F/ M, T% x+ ?
to reduced levels of a voltage-gated sodium channel subunit, Nav1.1. Restoring
; [( F$ q0 o, ~! s; jNav1.1 levels specifically in inhibitory interneurons improves oscillatory
( d# Q5 P) X- M4 k: [' W0 ?rhythms and memory in AD mice, offering a new therapeutic approach for
" F# B' ?% u3 ppotentially treating cognitive disorders. The image was created by Arantxa
3 e" A1 ~, T0 U& ?, zEsteban (original paintings “Ondas 1” and “Ondas 2”) and Jorge J. Palop 8 {+ @4 o# D( s
(electronic recreation).
: S( j+ D* {1 [* I; [+ A8 e[hide][/hide]

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